Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q09195

- ERG24_SCHPO

UniProt

Q09195 - ERG24_SCHPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Delta(14)-sterol reductase

Gene

erg24

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol.By similarity

Catalytic activityi

4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol + NADPH.

Pathwayi

GO - Molecular functioni

  1. delta14-sterol reductase activity Source: PomBase

GO - Biological processi

  1. ergosterol biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_188316. Activation of gene expression by SREBF (SREBP).
UniPathwayiUPA00770; UER00755.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta(14)-sterol reductase (EC:1.3.1.70)
Alternative name(s):
C-14 sterol reductase
Sterol C14-reductase
Gene namesi
Name:erg24
ORF Names:SPBC16G5.18
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC16G5.18.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. endoplasmic reticulum membrane Source: PomBase
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Delta(14)-sterol reductasePRO_0000207493Add
BLAST

Proteomic databases

MaxQBiQ09195.

Interactioni

Protein-protein interaction databases

MINTiMINT-4693879.
STRINGi4896.SPBC16G5.18-1.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72042.
HOGENOMiHOG000193296.
InParanoidiQ09195.
KOiK00222.
OMAiDWEKYCK.
OrthoDBiEOG7HB5MF.
PhylomeDBiQ09195.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09195-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKGAVKKEK FEYEFFGPIG ALGVTVLTTV VSFGSFYICN EEGCPAKFSK
60 70 80 90 100
ISHIFKKTPL FDQKSLILYL LWFSTLTLLW KCTNGKWAKG TPIDDKGTRL
110 120 130 140 150
LYKINGFNSA CLILGVVCTS IYLLGASCME FIWDNFLQLM FAAYVFSVVL
160 170 180 190 200
CTFCYVQSFF GKQQLAKGGT SGNILFDWFI GRSLNPRIGN FDIKCFCELR
210 220 230 240 250
PGLILWVVFD IAFACHQYLV LGGRITDSMV LVIIFHTWYV LDSLINESAV
260 270 280 290 300
LTTMDITTDG FGYMLSFGDL VWVPFLYSLQ ARYLAFHPVD LGLVKTLAIL
310 320 330 340 350
CLQFLGYYIF RGANGQKNRF RSNPNDPKLK HLKFIQTKRG TKLLTSGWWG
360 370 380 390 400
MARHINYFGD WIMAWAWCLP AGFGSPIPYF YVAYFGVLLV HRNARDDHKC
410 420
RVKYGEDWEK YCKAVKYRII PYVY
Length:424
Mass (Da):48,560
Last modified:November 1, 1996 - v1
Checksum:i1D3CE704F1E5EF5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36039 mRNA. Translation: AAA74121.1.
CU329671 Genomic DNA. Translation: CAA19037.1.
PIRiJC4057.
RefSeqiNP_596767.1. NM_001023787.2.

Genome annotation databases

EnsemblFungiiSPBC16G5.18.1; SPBC16G5.18.1:pep; SPBC16G5.18.
GeneIDi2540113.
KEGGispo:SPBC16G5.18.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36039 mRNA. Translation: AAA74121.1 .
CU329671 Genomic DNA. Translation: CAA19037.1 .
PIRi JC4057.
RefSeqi NP_596767.1. NM_001023787.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4693879.
STRINGi 4896.SPBC16G5.18-1.

Proteomic databases

MaxQBi Q09195.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC16G5.18.1 ; SPBC16G5.18.1:pep ; SPBC16G5.18 .
GeneIDi 2540113.
KEGGi spo:SPBC16G5.18.

Organism-specific databases

PomBasei SPBC16G5.18.

Phylogenomic databases

eggNOGi NOG72042.
HOGENOMi HOG000193296.
InParanoidi Q09195.
KOi K00222.
OMAi DWEKYCK.
OrthoDBi EOG7HB5MF.
PhylomeDBi Q09195.

Enzyme and pathway databases

UniPathwayi UPA00770 ; UER00755 .
Reactomei REACT_188316. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

NextBioi 20801249.
PROi Q09195.

Family and domain databases

InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view ]
Pfami PF01222. ERG4_ERG24. 1 hit.
[Graphical view ]
PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of an ERG24 homolog from Schizosaccharomyces pombe."
    Smith S.
    Gene 155:139-140(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SP66.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiERG24_SCHPO
AccessioniPrimary (citable) accession number: Q09195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3