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Q09195

- ERG24_SCHPO

UniProt

Q09195 - ERG24_SCHPO

Protein

Delta(14)-sterol reductase

Gene

erg24

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol.By similarity

    Catalytic activityi

    4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. delta14-sterol reductase activity Source: PomBase

    GO - Biological processi

    1. ergosterol biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_188316. Activation of gene expression by SREBF (SREBP).
    UniPathwayiUPA00770; UER00755.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta(14)-sterol reductase (EC:1.3.1.70)
    Alternative name(s):
    C-14 sterol reductase
    Sterol C14-reductase
    Gene namesi
    Name:erg24
    ORF Names:SPBC16G5.18
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC16G5.18.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. endoplasmic reticulum membrane Source: PomBase
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Delta(14)-sterol reductasePRO_0000207493Add
    BLAST

    Proteomic databases

    MaxQBiQ09195.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4693879.
    STRINGi4896.SPBC16G5.18-1.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ERG4/ERG24 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72042.
    HOGENOMiHOG000193296.
    KOiK00222.
    OMAiDWEKYCK.
    OrthoDBiEOG7HB5MF.
    PhylomeDBiQ09195.

    Family and domain databases

    InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
    IPR018083. Sterol_reductase_CS.
    [Graphical view]
    PfamiPF01222. ERG4_ERG24. 1 hit.
    [Graphical view]
    PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
    PS01018. STEROL_REDUCT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09195-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKGAVKKEK FEYEFFGPIG ALGVTVLTTV VSFGSFYICN EEGCPAKFSK    50
    ISHIFKKTPL FDQKSLILYL LWFSTLTLLW KCTNGKWAKG TPIDDKGTRL 100
    LYKINGFNSA CLILGVVCTS IYLLGASCME FIWDNFLQLM FAAYVFSVVL 150
    CTFCYVQSFF GKQQLAKGGT SGNILFDWFI GRSLNPRIGN FDIKCFCELR 200
    PGLILWVVFD IAFACHQYLV LGGRITDSMV LVIIFHTWYV LDSLINESAV 250
    LTTMDITTDG FGYMLSFGDL VWVPFLYSLQ ARYLAFHPVD LGLVKTLAIL 300
    CLQFLGYYIF RGANGQKNRF RSNPNDPKLK HLKFIQTKRG TKLLTSGWWG 350
    MARHINYFGD WIMAWAWCLP AGFGSPIPYF YVAYFGVLLV HRNARDDHKC 400
    RVKYGEDWEK YCKAVKYRII PYVY 424
    Length:424
    Mass (Da):48,560
    Last modified:November 1, 1996 - v1
    Checksum:i1D3CE704F1E5EF5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36039 mRNA. Translation: AAA74121.1.
    CU329671 Genomic DNA. Translation: CAA19037.1.
    PIRiJC4057.
    RefSeqiNP_596767.1. NM_001023787.2.

    Genome annotation databases

    EnsemblFungiiSPBC16G5.18.1; SPBC16G5.18.1:pep; SPBC16G5.18.
    GeneIDi2540113.
    KEGGispo:SPBC16G5.18.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36039 mRNA. Translation: AAA74121.1 .
    CU329671 Genomic DNA. Translation: CAA19037.1 .
    PIRi JC4057.
    RefSeqi NP_596767.1. NM_001023787.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4693879.
    STRINGi 4896.SPBC16G5.18-1.

    Proteomic databases

    MaxQBi Q09195.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC16G5.18.1 ; SPBC16G5.18.1:pep ; SPBC16G5.18 .
    GeneIDi 2540113.
    KEGGi spo:SPBC16G5.18.

    Organism-specific databases

    PomBasei SPBC16G5.18.

    Phylogenomic databases

    eggNOGi NOG72042.
    HOGENOMi HOG000193296.
    KOi K00222.
    OMAi DWEKYCK.
    OrthoDBi EOG7HB5MF.
    PhylomeDBi Q09195.

    Enzyme and pathway databases

    UniPathwayi UPA00770 ; UER00755 .
    Reactomei REACT_188316. Activation of gene expression by SREBF (SREBP).

    Miscellaneous databases

    NextBioi 20801249.
    PROi Q09195.

    Family and domain databases

    InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
    IPR018083. Sterol_reductase_CS.
    [Graphical view ]
    Pfami PF01222. ERG4_ERG24. 1 hit.
    [Graphical view ]
    PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
    PS01018. STEROL_REDUCT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of an ERG24 homolog from Schizosaccharomyces pombe."
      Smith S.
      Gene 155:139-140(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: SP66.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiERG24_SCHPO
    AccessioniPrimary (citable) accession number: Q09195
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3