ID   CDD_SCHPO               Reviewed;         133 AA.
AC   Q09190; Q9UTJ5;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 2.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=Putative cytidine deaminase;
DE            Short=CDA;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
GN   Name=pcd1; ORFNames=SPAC1556.04c;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=97298308; PubMed=9153756;
RX   DOI=10.1002/(SICI)1097-0061(199704)13:5<463::AID-YEA89>3.3.CO;2-2;
RA   Platt G.M., Price C.;
RT   "Isolation of a Schizosaccharomyces pombe gene which in high copy
RT   confers resistance to the nucleoside analogue 5-azacytidine.";
RL   Yeast 13:463-474(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: This enzyme scavenge exogenous and endogenous cytidine
CC       and 2'-deoxycytidine for UMP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
CC   -!- COFACTOR: Zinc (By similarity).
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; X98329; CAA66974.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAB61215.1; -; Genomic_DNA.
DR   PIR; T50083; T50083.
DR   RefSeq; NP_594321.1; -.
DR   HSSP; P19079; 1JTK.
DR   GeneID; 2541551; -.
DR   KEGG; spo:SPAC1556.04c; -.
DR   NMPDR; fig|4896.1.peg.4291; -.
DR   GeneDB_Spombe; SPAC1556.04c; -.
DR   OMA; Q09190; YMTKLDG.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-002430-MON; -.
DR   BRENDA; 3.5.4.5; 653.
DR   ArrayExpress; Q09190; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB_SPombe.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046087; P:cytidine metabolic process; IEA:InterPro.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_Zn_bd.
DR   InterPro; IPR006262; Cyt_deam_tetra.
DR   PANTHER; PTHR11644:SF2; Cyt_deam_tetra; 1.
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR   TIGRFAMs; TIGR01354; cyt_deam_tetra; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Hydrolase; Metal-binding; Zinc.
FT   CHAIN         1    133       Putative cytidine deaminase.
FT                                /FTId=PRO_0000171684.
FT   REGION       46     48       Substrate binding (By similarity).
FT   ACT_SITE     59     59       Proton donor (By similarity).
FT   METAL        57     57       Zinc; catalytic (By similarity).
FT   METAL        89     89       Zinc; catalytic (By similarity).
FT   METAL        92     92       Zinc; catalytic (By similarity).
FT   CONFLICT     15     15       K -> E (in Ref. 1; CAA66974).
SQ   SEQUENCE   133 AA;  14892 MW;  AAC2572AE8D879A4 CRC64;
     MEKEDIEKLF QEVKKSLQYS YCPYSNFAVG ACVVSDDKNT YIYGANVENA SYGNCICAER
     VAITKAVSMG YTKFMAIGVM SAKGRVTPCG ICRQVIREFS KDINVYMFHD DGGYDMKTIE
     ELLPDSFGPD DLK
//