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Q09190

- CDD_SCHPO

UniProt

Q09190 - CDD_SCHPO

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Protein

Putative cytidine deaminase

Gene

pcd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Zinc.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Zinc; catalyticBy similarity
Active sitei59 – 591Proton donorBy similarity
Metal bindingi89 – 891Zinc; catalyticBy similarity
Metal bindingi92 – 921Zinc; catalyticBy similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: PomBase
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cytidine catabolic process Source: PomBase
  2. pyrimidine nucleobase metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_210679. Pyrimidine salvage reactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytidine deaminase (EC:3.5.4.5)
Short name:
CDA
Alternative name(s):
Cytidine aminohydrolase
Gene namesi
Name:pcd1
ORF Names:SPAC1556.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1556.04c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133Putative cytidine deaminasePRO_0000171684Add
BLAST

Proteomic databases

MaxQBiQ09190.

Interactioni

Protein-protein interaction databases

MINTiMINT-4693866.
STRINGi4896.SPAC1556.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 10198CMP/dCMP deaminase zinc-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 483Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0295.
HOGENOMiHOG000014707.
InParanoidiQ09190.
KOiK01489.
OMAiTDWAVYM.
OrthoDBiEOG7NCVG0.
PhylomeDBiQ09190.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09190-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKEDIEKLF QEVKKSLQYS YCPYSNFAVG ACVVSDDKNT YIYGANVENA
60 70 80 90 100
SYGNCICAER VAITKAVSMG YTKFMAIGVM SAKGRVTPCG ICRQVIREFS
110 120 130
KDINVYMFHD DGGYDMKTIE ELLPDSFGPD DLK
Length:133
Mass (Da):14,892
Last modified:August 14, 2001 - v2
Checksum:iAAC2572AE8D879A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151K → E in CAA66974. (PubMed:9153756)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98329 Genomic DNA. Translation: CAA66974.1.
CU329670 Genomic DNA. Translation: CAB61215.1.
PIRiT50083.
RefSeqiNP_594321.1. NM_001019743.2.

Genome annotation databases

EnsemblFungiiSPAC1556.04c.1; SPAC1556.04c.1:pep; SPAC1556.04c.
GeneIDi2541551.
KEGGispo:SPAC1556.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98329 Genomic DNA. Translation: CAA66974.1 .
CU329670 Genomic DNA. Translation: CAB61215.1 .
PIRi T50083.
RefSeqi NP_594321.1. NM_001019743.2.

3D structure databases

ProteinModelPortali Q09190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4693866.
STRINGi 4896.SPAC1556.04c-1.

Proteomic databases

MaxQBi Q09190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1556.04c.1 ; SPAC1556.04c.1:pep ; SPAC1556.04c .
GeneIDi 2541551.
KEGGi spo:SPAC1556.04c.

Organism-specific databases

PomBasei SPAC1556.04c.

Phylogenomic databases

eggNOGi COG0295.
HOGENOMi HOG000014707.
InParanoidi Q09190.
KOi K01489.
OMAi TDWAVYM.
OrthoDBi EOG7NCVG0.
PhylomeDBi Q09190.

Enzyme and pathway databases

Reactomei REACT_210679. Pyrimidine salvage reactions.

Miscellaneous databases

NextBioi 20802647.
PROi Q09190.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a Schizosaccharomyces pombe gene which in high copy confers resistance to the nucleoside analogue 5-azacytidine."
    Platt G.M., Price C.
    Yeast 13:463-474(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiCDD_SCHPO
AccessioniPrimary (citable) accession number: Q09190
Secondary accession number(s): Q9UTJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3