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Q09190

- CDD_SCHPO

UniProt

Q09190 - CDD_SCHPO

Protein

Putative cytidine deaminase

Gene

pcd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

    Catalytic activityi

    Cytidine + H2O = uridine + NH3.
    2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi57 – 571Zinc; catalyticBy similarity
    Active sitei59 – 591Proton donorBy similarity
    Metal bindingi89 – 891Zinc; catalyticBy similarity
    Metal bindingi92 – 921Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. cytidine deaminase activity Source: PomBase
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cytidine catabolic process Source: PomBase
    2. pyrimidine nucleobase metabolic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_210679. Pyrimidine salvage reactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative cytidine deaminase (EC:3.5.4.5)
    Short name:
    CDA
    Alternative name(s):
    Cytidine aminohydrolase
    Gene namesi
    Name:pcd1
    ORF Names:SPAC1556.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1556.04c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 133133Putative cytidine deaminasePRO_0000171684Add
    BLAST

    Proteomic databases

    MaxQBiQ09190.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4693866.
    STRINGi4896.SPAC1556.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 10198CMP/dCMP deaminase zinc-bindingAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni46 – 483Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    HOGENOMiHOG000014707.
    KOiK01489.
    OMAiTDWAVYM.
    OrthoDBiEOG7NCVG0.
    PhylomeDBiQ09190.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09190-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKEDIEKLF QEVKKSLQYS YCPYSNFAVG ACVVSDDKNT YIYGANVENA    50
    SYGNCICAER VAITKAVSMG YTKFMAIGVM SAKGRVTPCG ICRQVIREFS 100
    KDINVYMFHD DGGYDMKTIE ELLPDSFGPD DLK 133
    Length:133
    Mass (Da):14,892
    Last modified:August 14, 2001 - v2
    Checksum:iAAC2572AE8D879A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151K → E in CAA66974. (PubMed:9153756)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98329 Genomic DNA. Translation: CAA66974.1.
    CU329670 Genomic DNA. Translation: CAB61215.1.
    PIRiT50083.
    RefSeqiNP_594321.1. NM_001019743.2.

    Genome annotation databases

    EnsemblFungiiSPAC1556.04c.1; SPAC1556.04c.1:pep; SPAC1556.04c.
    GeneIDi2541551.
    KEGGispo:SPAC1556.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98329 Genomic DNA. Translation: CAA66974.1 .
    CU329670 Genomic DNA. Translation: CAB61215.1 .
    PIRi T50083.
    RefSeqi NP_594321.1. NM_001019743.2.

    3D structure databases

    ProteinModelPortali Q09190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4693866.
    STRINGi 4896.SPAC1556.04c-1.

    Proteomic databases

    MaxQBi Q09190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1556.04c.1 ; SPAC1556.04c.1:pep ; SPAC1556.04c .
    GeneIDi 2541551.
    KEGGi spo:SPAC1556.04c.

    Organism-specific databases

    PomBasei SPAC1556.04c.

    Phylogenomic databases

    eggNOGi COG0295.
    HOGENOMi HOG000014707.
    KOi K01489.
    OMAi TDWAVYM.
    OrthoDBi EOG7NCVG0.
    PhylomeDBi Q09190.

    Enzyme and pathway databases

    Reactomei REACT_210679. Pyrimidine salvage reactions.

    Miscellaneous databases

    NextBioi 20802647.
    PROi Q09190.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a Schizosaccharomyces pombe gene which in high copy confers resistance to the nucleoside analogue 5-azacytidine."
      Platt G.M., Price C.
      Yeast 13:463-474(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiCDD_SCHPO
    AccessioniPrimary (citable) accession number: Q09190
    Secondary accession number(s): Q9UTJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3