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Protein

Putative cytidine deaminase

Gene

pcd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Zinc; catalyticBy similarity
Active sitei59 – 591Proton donorBy similarity
Metal bindingi89 – 891Zinc; catalyticBy similarity
Metal bindingi92 – 921Zinc; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-73614. Pyrimidine salvage reactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytidine deaminase (EC:3.5.4.5)
Short name:
CDA
Alternative name(s):
Cytidine aminohydrolase
Gene namesi
Name:pcd1
ORF Names:SPAC1556.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1556.04c.
PomBaseiSPAC1556.04c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133Putative cytidine deaminasePRO_0000171684Add
BLAST

Proteomic databases

MaxQBiQ09190.

Interactioni

Protein-protein interaction databases

BioGridi278050. 7 interactions.
MINTiMINT-4693866.

Structurei

3D structure databases

ProteinModelPortaliQ09190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 130127CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 483Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000014707.
InParanoidiQ09190.
KOiK01489.
OMAiERMAKCS.
OrthoDBiEOG092C4VW8.
PhylomeDBiQ09190.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKEDIEKLF QEVKKSLQYS YCPYSNFAVG ACVVSDDKNT YIYGANVENA
60 70 80 90 100
SYGNCICAER VAITKAVSMG YTKFMAIGVM SAKGRVTPCG ICRQVIREFS
110 120 130
KDINVYMFHD DGGYDMKTIE ELLPDSFGPD DLK
Length:133
Mass (Da):14,892
Last modified:August 14, 2001 - v2
Checksum:iAAC2572AE8D879A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151K → E in CAA66974 (PubMed:9153756).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98329 Genomic DNA. Translation: CAA66974.1.
CU329670 Genomic DNA. Translation: CAB61215.1.
PIRiT50083.
RefSeqiNP_594321.1. NM_001019743.2.

Genome annotation databases

EnsemblFungiiSPAC1556.04c.1; SPAC1556.04c.1:pep; SPAC1556.04c.
GeneIDi2541551.
KEGGispo:SPAC1556.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98329 Genomic DNA. Translation: CAA66974.1.
CU329670 Genomic DNA. Translation: CAB61215.1.
PIRiT50083.
RefSeqiNP_594321.1. NM_001019743.2.

3D structure databases

ProteinModelPortaliQ09190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278050. 7 interactions.
MINTiMINT-4693866.

Proteomic databases

MaxQBiQ09190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1556.04c.1; SPAC1556.04c.1:pep; SPAC1556.04c.
GeneIDi2541551.
KEGGispo:SPAC1556.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1556.04c.
PomBaseiSPAC1556.04c.

Phylogenomic databases

HOGENOMiHOG000014707.
InParanoidiQ09190.
KOiK01489.
OMAiERMAKCS.
OrthoDBiEOG092C4VW8.
PhylomeDBiQ09190.

Enzyme and pathway databases

ReactomeiR-SPO-73614. Pyrimidine salvage reactions.

Miscellaneous databases

PROiQ09190.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDD_SCHPO
AccessioniPrimary (citable) accession number: Q09190
Secondary accession number(s): Q9UTJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.