Reviewed, UniProtKB/Swiss-Prot Q09190 (CDD_SCHPO)

Names and origin

Protein names

Recommended name:
    Putative cytidine deaminase
      Short name=CDA
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase

Gene names

Name:	pcd1
ORF Names:	SPAC1556.04c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 133	133	Putative cytidine deaminase		PRO_0000171684
Regions
	Region	46 – 48	3	Substrate binding By similarity
Sites
	Active site	59	1	Proton donor By similarity
	Metal binding	57	1	Zinc; catalytic By similarity
	Metal binding	89	1	Zinc; catalytic By similarity
	Metal binding	92	1	Zinc; catalytic By similarity
Experimental info
	Sequence conflict	15	1	K → E in CAA66974. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q09190-1 [UniParc]. Last modified August 14, 2001. Version 2. Checksum: AAC2572AE8D879A4	FASTA	133	14,892
	10 20 30 40 50 60 MEKEDIEKLF QEVKKSLQYS YCPYSNFAVG ACVVSDDKNT YIYGANVENA SYGNCICAER 70 80 90 100 110 120 VAITKAVSMG YTKFMAIGVM SAKGRVTPCG ICRQVIREFS KDINVYMFHD DGGYDMKTIE 130 ELLPDSFGPD DLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a Schizosaccharomyces pombe gene which in high copy confers resistance to the nucleoside analogue 5-azacytidine." Platt G.M., Price C. Yeast 13:463-474(1997) [PubMed: 9153756] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X98329 Genomic DNA. Translation: CAA66974.1. CU329670 Genomic DNA. Translation: CAB61215.1.
PIR	T50083.
RefSeq	NP_594321.1.
3D structure databases
SMR	Q09190. Positions 4-132.
ModBase	Search...
Protein-protein interaction databases
STRING	Q09190.
Genome annotation databases
GeneID	2541551.
GenomeReviews	Gene locus pcd1 in contig CU329670_GR.
KEGG	spo:SPAC1556.04c.
NMPDR	fig|4896.1.peg.4291.
Organism-specific databases
GeneDB_Spombe	SPAC1556.04c.
Phylogenomic databases
eggNOG	fuNOG10856.
HOGENOM	HBG352939.
OMA	YMTKLDG.
OrthoDB	EOG9JQ5DV.
PhylomeDB	Q09190.
Enzyme and pathway databases
BRENDA	3.5.4.5. 653.
Gene expression databases
ArrayExpress	Q09190.
Family and domain databases
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR006262. Cyt_deam_tetra. IPR016193. Cytidine_deaminase-like. [Graphical view]
PANTHER	PTHR11644:SF2. Cyt_deam_tetra. 1 hit.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01354. cyt_deam_tetra. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_SCHPO

Accession

Primary (citable) accession number: Q09190
Secondary accession number(s): Q9UTJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	August 14, 2001
Last modified:	February 9, 2010
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)