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Protein

ADP,ATP carrier protein

Gene

anc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001NucleotideBy similarity

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: PomBase
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • mitochondrial ATP transmembrane transport Source: PomBase
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-SPO-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein
Alternative name(s):
ADP/ATP translocase
Adenine nucleotide translocator
Short name:
ANT
Gene namesi
Name:anc1
ORF Names:SPBC530.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC530.10c.
PomBaseiSPBC530.10c. anc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 5835Helical; Name=1By similarityAdd
BLAST
Transmembranei95 – 11925Helical; Name=2By similarityAdd
BLAST
Transmembranei128 – 16235Helical; Name=3By similarityAdd
BLAST
Transmembranei197 – 22428Helical; Name=4By similarityAdd
BLAST
Transmembranei229 – 26335Helical; Name=5By similarityAdd
BLAST
Transmembranei292 – 31726Helical; Name=6By similarityAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322ADP,ATP carrier proteinPRO_0000090592Add
BLAST

Proteomic databases

MaxQBiQ09188.
PRIDEiQ09188.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi277416. 5 interactions.
IntActiQ09188. 1 interaction.
MINTiMINT-4693839.

Structurei

3D structure databases

ProteinModelPortaliQ09188.
SMRiQ09188. Positions 25-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 11894Solcar 1Add
BLAST
Repeati130 – 22293Solcar 2Add
BLAST
Repeati230 – 31687Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi257 – 2626Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000165727.
InParanoidiQ09188.
KOiK05863.
OMAiECFKRTA.
OrthoDBiEOG7NCVDV.
PhylomeDBiQ09188.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSSAAAAA STPVNANTIT ETKNSTFFFD FMMGGVSAAV SKTAAAPIER
60 70 80 90 100
VKLLIQNQDE MIRAGRLSHR YKGIGECFKR TAAEEGVISL WRGNTANVLR
110 120 130 140 150
YFPTQALNFA FKDKFKKMFG YKKERDGYAK WFAGNLASGG AAGAASLLFV
160 170 180 190 200
YSLDYARTRL ANDAKSAKKG GERQFNGLVD VYRKTYRSDG LRGLYRGFGP
210 220 230 240 250
SVVGIVVYRG LYFGMYDTLK PVVLVGPLEG NFLASFLLGW AVTTGSGVAS
260 270 280 290 300
YPLDTIRRRM MMTSGEAVKY SSSFECGRQI LAKEGARSFF KGAGANILRG
310 320
VAGAGVLSIY DQVQLLMFGK KF
Length:322
Mass (Da):35,020
Last modified:November 1, 1996 - v1
Checksum:i8AC3D16A40F41AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49974 Genomic DNA. Translation: CAA90275.1.
CU329671 Genomic DNA. Translation: CAA19176.1.
D89102 mRNA. Translation: BAA13765.1.
PIRiT40526.
T42011.
RefSeqiNP_595323.1. NM_001021230.2.

Genome annotation databases

EnsemblFungiiSPBC530.10c.1; SPBC530.10c.1:pep; SPBC530.10c.
GeneIDi2540900.
KEGGispo:SPBC530.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49974 Genomic DNA. Translation: CAA90275.1.
CU329671 Genomic DNA. Translation: CAA19176.1.
D89102 mRNA. Translation: BAA13765.1.
PIRiT40526.
T42011.
RefSeqiNP_595323.1. NM_001021230.2.

3D structure databases

ProteinModelPortaliQ09188.
SMRiQ09188. Positions 25-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277416. 5 interactions.
IntActiQ09188. 1 interaction.
MINTiMINT-4693839.

Proteomic databases

MaxQBiQ09188.
PRIDEiQ09188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC530.10c.1; SPBC530.10c.1:pep; SPBC530.10c.
GeneIDi2540900.
KEGGispo:SPBC530.10c.

Organism-specific databases

EuPathDBiFungiDB:SPBC530.10c.
PomBaseiSPBC530.10c. anc1.

Phylogenomic databases

HOGENOMiHOG000165727.
InParanoidiQ09188.
KOiK05863.
OMAiECFKRTA.
OrthoDBiEOG7NCVDV.
PhylomeDBiQ09188.

Enzyme and pathway databases

ReactomeiR-SPO-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiQ09188.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the gene encoding the mitochondrial adenine nucleotide carrier of Schizosaccharomyces pombe by functional complementation in Saccharomyces cerevisiae."
    Couzin N., Trezeguet V., Saux A.L., Lauquin G.J.-M.
    Gene 171:113-117(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-305.
    Strain: PR745.

Entry informationi

Entry nameiADT_SCHPO
AccessioniPrimary (citable) accession number: Q09188
Secondary accession number(s): P78754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.