Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Curved DNA-binding protein

Gene

cdb4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A non-essential protein that preferentially binds curved DNA. Binds non-curved DNA with a much lower affinity.

GO - Molecular functioni

  • DNA binding Source: PomBase
  • metallopeptidase activity Source: PomBase
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Curved DNA-binding protein
Alternative name(s):
42 kDa protein
Gene namesi
Name:cdb4
ORF Names:SPAC23H4.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H4.09.
PomBaseiSPAC23H4.09. cdb4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Curved DNA-binding proteinPRO_0000148991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphoserine1 Publication
Modified residuei362 – 3621Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09184.

PTM databases

iPTMnetiQ09184.

Interactioni

Protein-protein interaction databases

BioGridi278308. 6 interactions.
MINTiMINT-4693826.

Structurei

3D structure databases

ProteinModelPortaliQ09184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi368 – 3758Nuclear localization signalSequence analysis

Sequence similaritiesi

Belongs to the peptidase M24 family.Curated

Phylogenomic databases

HOGENOMiHOG000168207.
InParanoidiQ09184.
OMAiKNWAVTE.
OrthoDBiEOG7TQV9H.
PhylomeDBiQ09184.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
InterProiIPR004545. PA2G4.
IPR000994. Pept_M24_structural-domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00495. crvDNA_42K. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKEATSET AVDYSLSNPE TVNKYKIAGE VSQNVIKKVV ELCQPGAKIY
60 70 80 90 100
DICVRGDELL NEAIKKVYRT KDAYKGIAFP TAVSPNDMAA HLSPLKSDPE
110 120 130 140 150
ANLALKSGDV VKILLGAHID GFASLVATTT VVSEEPVTGP AADVIAAASA
160 170 180 190 200
ALKAAQRTIK PGNTNWQVTD IVDKIATSYG CKPVAGMLSH QQEREVIDGK
210 220 230 240 250
KQVILNPSDS QRSEMDTFTF EEGEVYGVDI LVSTSPSGKV KRSDIATRIY
260 270 280 290 300
KKTDTTYMLK LQASRKVYSE IQTKFGPFPF STRNISFDSR TNMGLNECTS
310 320 330 340 350
HKLLFPYEVL LDKDGGIVAE FYSTIALTKK GTIILSDSEP KEDFIKSDKK
360 370 380
VEDPEIVALL ETPIKVTKNK KKSKKPSKAN E
Length:381
Mass (Da):41,598
Last modified:November 1, 1995 - v1
Checksum:iA87AE1346597CF49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14907 Genomic DNA. Translation: BAA03607.1.
CU329670 Genomic DNA. Translation: CAB11663.1.
PIRiS46583.
RefSeqiNP_593397.1. NM_001018829.2.

Genome annotation databases

EnsemblFungiiSPAC23H4.09.1; SPAC23H4.09.1:pep; SPAC23H4.09.
GeneIDi2541817.
KEGGispo:SPAC23H4.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14907 Genomic DNA. Translation: BAA03607.1.
CU329670 Genomic DNA. Translation: CAB11663.1.
PIRiS46583.
RefSeqiNP_593397.1. NM_001018829.2.

3D structure databases

ProteinModelPortaliQ09184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278308. 6 interactions.
MINTiMINT-4693826.

PTM databases

iPTMnetiQ09184.

Proteomic databases

MaxQBiQ09184.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23H4.09.1; SPAC23H4.09.1:pep; SPAC23H4.09.
GeneIDi2541817.
KEGGispo:SPAC23H4.09.

Organism-specific databases

EuPathDBiFungiDB:SPAC23H4.09.
PomBaseiSPAC23H4.09. cdb4.

Phylogenomic databases

HOGENOMiHOG000168207.
InParanoidiQ09184.
OMAiKNWAVTE.
OrthoDBiEOG7TQV9H.
PhylomeDBiQ09184.

Miscellaneous databases

PROiQ09184.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
InterProiIPR004545. PA2G4.
IPR000994. Pept_M24_structural-domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00495. crvDNA_42K. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A fission yeast gene encoding a protein that preferentially associates with curved DNA."
    Yamada H., Mori H., Momoi H., Nakagawa Y., Ueguchi C., Mizuno T.
    Yeast 10:883-894(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 5-31.
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8 AND THR-362, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCDB4_SCHPO
AccessioniPrimary (citable) accession number: Q09184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.