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Protein

Glutamine synthetase

Gene

gln1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glutamate-ammonia ligase activity Source: PomBase

GO - Biological processi

  • ammonia assimilation cycle Source: PomBase
  • cellular response to nitrogen starvation Source: PomBase
  • glutamine biosynthetic process Source: PomBase
  • nitrogen utilization Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-210455. Astrocytic Glutamate-Glutamine Uptake And Metabolism.
R-SPO-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:gln1
ORF Names:SPAC23H4.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H4.06.
PomBaseiSPAC23H4.06. gln1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001531621 – 359Glutamine synthetaseAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273Phosphoserine1 Publication1
Modified residuei303Phosphothreonine1 Publication1
Modified residuei305Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09179.
PRIDEiQ09179.

PTM databases

iPTMnetiQ09179.
SwissPalmiQ09179.

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

BioGridi278246. 1 interactor.
MINTiMINT-4693794.

Structurei

3D structure databases

ProteinModelPortaliQ09179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

HOGENOMiHOG000061500.
InParanoidiQ09179.
KOiK01915.
OMAiKTMRNDG.
OrthoDBiEOG092C2OM1.
PhylomeDBiQ09179.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_b-grasp.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SMARTiSM01230. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQYDVEPLL SKAAILNKYA DLPQNGKVMA EYIWIDGFNH LRSKTMTLDA
60 70 80 90 100
KPSSIDQLRV WNFDGSSTGQ APGNNSDTLL KPVAMYNDPF RRGDNILVLA
110 120 130 140 150
ACYTADGSPN GFNHRDACAK LLEKHADKET WFGIEQEYTM LDYYDRPFGW
160 170 180 190 200
PKGGFPGPQG PFYCGVGTGR VFARDIVEAH YKACLYAGIN ISGINAEVMP
210 220 230 240 250
SQWEYQVGPC AGIEMGDQLW MSRFLLHRIA EDFGVKISFH PKPILGDWNG
260 270 280 290 300
AGCHTNVSTK DTRAEGGIKA IESYLEKFAK RHKEHIAVYG DDNDLRLTGR
310 320 330 340 350
HETGSIDKFT YGVADRGASV RIPRSVAMNG CGYFEDRRPA SSIDPYLVTG

IITETMFEH
Length:359
Mass (Da):40,018
Last modified:July 15, 1998 - v2
Checksum:i96AACB6A912B3D0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11660.1.
PIRiT38322.
RefSeqiNP_593400.1. NM_001018832.2.

Genome annotation databases

EnsemblFungiiSPAC23H4.06.1; SPAC23H4.06.1:pep; SPAC23H4.06.
GeneIDi2541752.
KEGGispo:SPAC23H4.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11660.1.
PIRiT38322.
RefSeqiNP_593400.1. NM_001018832.2.

3D structure databases

ProteinModelPortaliQ09179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278246. 1 interactor.
MINTiMINT-4693794.

PTM databases

iPTMnetiQ09179.
SwissPalmiQ09179.

Proteomic databases

MaxQBiQ09179.
PRIDEiQ09179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23H4.06.1; SPAC23H4.06.1:pep; SPAC23H4.06.
GeneIDi2541752.
KEGGispo:SPAC23H4.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC23H4.06.
PomBaseiSPAC23H4.06. gln1.

Phylogenomic databases

HOGENOMiHOG000061500.
InParanoidiQ09179.
KOiK01915.
OMAiKTMRNDG.
OrthoDBiEOG092C2OM1.
PhylomeDBiQ09179.

Enzyme and pathway databases

ReactomeiR-SPO-210455. Astrocytic Glutamate-Glutamine Uptake And Metabolism.
R-SPO-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

PROiQ09179.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_b-grasp.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SMARTiSM01230. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLNA_SCHPO
AccessioniPrimary (citable) accession number: Q09179
Secondary accession number(s): O13949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.