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Q09179

- GLNA_SCHPO

UniProt

Q09179 - GLNA_SCHPO

Protein

Glutamine synthetase

Gene

gln1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: PomBase

    GO - Biological processi

    1. ammonia assimilation cycle Source: PomBase
    2. cellular response to nitrogen starvation Source: PomBase
    3. glutamine biosynthetic process Source: PomBase
    4. nitrogen utilization Source: PomBase

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_221562. Amino acid synthesis and interconversion (transamination).
    REACT_222095. Astrocytic Glutamate-Glutamine Uptake And Metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:gln1
    ORF Names:SPAC23H4.06
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC23H4.06.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Glutamine synthetasePRO_0000153162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731Phosphoserine1 Publication
    Modified residuei303 – 3031Phosphothreonine1 Publication
    Modified residuei305 – 3051Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ09179.
    PaxDbiQ09179.

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    BioGridi278246. 2 interactions.
    MINTiMINT-4693794.
    STRINGi4896.SPAC23H4.06-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09179.
    SMRiQ09179. Positions 23-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    HOGENOMiHOG000061500.
    KOiK01915.
    OMAiDVEYHCK.
    OrthoDBiEOG7GTTD8.
    PhylomeDBiQ09179.

    Family and domain databases

    Gene3Di3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09179-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQYDVEPLL SKAAILNKYA DLPQNGKVMA EYIWIDGFNH LRSKTMTLDA    50
    KPSSIDQLRV WNFDGSSTGQ APGNNSDTLL KPVAMYNDPF RRGDNILVLA 100
    ACYTADGSPN GFNHRDACAK LLEKHADKET WFGIEQEYTM LDYYDRPFGW 150
    PKGGFPGPQG PFYCGVGTGR VFARDIVEAH YKACLYAGIN ISGINAEVMP 200
    SQWEYQVGPC AGIEMGDQLW MSRFLLHRIA EDFGVKISFH PKPILGDWNG 250
    AGCHTNVSTK DTRAEGGIKA IESYLEKFAK RHKEHIAVYG DDNDLRLTGR 300
    HETGSIDKFT YGVADRGASV RIPRSVAMNG CGYFEDRRPA SSIDPYLVTG 350
    IITETMFEH 359
    Length:359
    Mass (Da):40,018
    Last modified:July 15, 1998 - v2
    Checksum:i96AACB6A912B3D0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB11660.1.
    PIRiT38322.
    RefSeqiNP_593400.1. NM_001018832.2.

    Genome annotation databases

    EnsemblFungiiSPAC23H4.06.1; SPAC23H4.06.1:pep; SPAC23H4.06.
    GeneIDi2541752.
    KEGGispo:SPAC23H4.06.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB11660.1 .
    PIRi T38322.
    RefSeqi NP_593400.1. NM_001018832.2.

    3D structure databases

    ProteinModelPortali Q09179.
    SMRi Q09179. Positions 23-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278246. 2 interactions.
    MINTi MINT-4693794.
    STRINGi 4896.SPAC23H4.06-1.

    Proteomic databases

    MaxQBi Q09179.
    PaxDbi Q09179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC23H4.06.1 ; SPAC23H4.06.1:pep ; SPAC23H4.06 .
    GeneIDi 2541752.
    KEGGi spo:SPAC23H4.06.

    Organism-specific databases

    PomBasei SPAC23H4.06.

    Phylogenomic databases

    eggNOGi COG0174.
    HOGENOMi HOG000061500.
    KOi K01915.
    OMAi DVEYHCK.
    OrthoDBi EOG7GTTD8.
    PhylomeDBi Q09179.

    Enzyme and pathway databases

    Reactomei REACT_221562. Amino acid synthesis and interconversion (transamination).
    REACT_222095. Astrocytic Glutamate-Glutamine Uptake And Metabolism.

    Miscellaneous databases

    NextBioi 20802843.
    PROi Q09179.

    Family and domain databases

    Gene3Di 3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; THR-303 AND SER-305, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiGLNA_SCHPO
    AccessioniPrimary (citable) accession number: Q09179
    Secondary accession number(s): O13949
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3