ID JAK1_CYPCA Reviewed; 1156 AA. AC Q09178; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 16-JUN-2009, entry version 75. DE RecName: Full=Tyrosine-protein kinase Jak1; DE EC=2.7.10.2; DE AltName: Full=Janus kinase 1; DE Short=Jak-1; GN Name=jak1; OS Cyprinus carpio (Common carp). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Cyprinus. OX NCBI_TaxID=7962; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RX MEDLINE=97047914; PubMed=8892755; DOI=10.1089/dna.1996.15.827; RA Chang M.S., Chang G.D., Leu J.H., Huang F.L., Chou C.K., Huang C.J., RA Lo T.B.; RT "Expression, characterization, and genomic structure of carp JAK1 RT kinase gene."; RL DNA Cell Biol. 15:827-844(1996). CC -!- FUNCTION: Tyrosine kinase of the non-receptor type (By CC similarity). CC -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a CC [protein]-L-tyrosine phosphate. CC -!- SUBCELLULAR LOCATION: Endomembrane system; Peripheral membrane CC protein (By similarity). Note=Wholly intracellular, possibly CC membrane associated (By similarity). CC -!- DOMAIN: Possesses two phosphotransferase domains. The second one CC probably contains the catalytic domain, while the presence of CC slight differences suggest a different role for domain 1. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. JAK subfamily. CC -!- SIMILARITY: Contains 1 FERM domain. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC -!- SIMILARITY: Contains 1 SH2 domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L24895; AAB38157.1; -; mRNA. DR EMBL; U53694; AAB38256.1; -; Genomic_DNA. DR EMBL; U53686; AAB38256.1; JOINED; Genomic_DNA. DR EMBL; U53687; AAB38256.1; JOINED; Genomic_DNA. DR EMBL; U53688; AAB38256.1; JOINED; Genomic_DNA. DR EMBL; U53689; AAB38256.1; JOINED; Genomic_DNA. DR EMBL; U53690; AAB38256.1; JOINED; Genomic_DNA. DR EMBL; U53691; AAB38256.1; JOINED; Genomic_DNA. DR EMBL; U53692; AAB38256.1; JOINED; Genomic_DNA. DR EMBL; U53693; AAB38256.1; JOINED; Genomic_DNA. DR HSSP; P11362; 1FGK. DR HOVERGEN; Q09178; -. DR BRENDA; 2.7.10.2; 3298. DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro. DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004718; F:Janus kinase activity; IEA:InterPro. DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kina...; IEA:EC. DR GO; GO:0005515; F:protein binding; IEA:InterPro. DR GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR019747; FERM_CS. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR009127; JAK. DR InterPro; IPR009128; JAK1. DR InterPro; IPR000719; Prot_kinase_core. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR000980; SH2. DR InterPro; IPR001245; Tyr_pkinase. DR InterPro; IPR008266; Tyr_pkinase_AS. DR InterPro; IPR016251; TyrPK_Jak. DR Pfam; PF07714; Pkinase_Tyr; 2. DR PIRSF; PIRSF000636; TyrPK_Jak; 1. DR PRINTS; PR01823; JANUSKINASE. DR PRINTS; PR01824; JANUSKINASE1. DR PRINTS; PR00109; TYRKINASE. DR ProDom; PD000001; Prot_kinase; 2. DR ProDom; PD000093; SH2; 1. DR SMART; SM00295; B41; 1. DR SMART; SM00252; SH2; 1. DR SMART; SM00219; TyrKc; 2. DR PROSITE; PS00660; FERM_1; FALSE_NEG. DR PROSITE; PS00661; FERM_2; FALSE_NEG. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS50001; SH2; FALSE_NEG. PE 2: Evidence at transcript level; KW ATP-binding; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; KW Repeat; SH2 domain; Transferase; Tyrosine-protein kinase. FT CHAIN 1 1156 Tyrosine-protein kinase Jak1. FT /FTId=PRO_0000088111. FT DOMAIN 32 419 FERM. FT DOMAIN 438 543 SH2; atypical. FT DOMAIN 583 857 Protein kinase 1. FT DOMAIN 875 1153 Protein kinase 2. FT NP_BIND 881 889 ATP (By similarity). FT COMPBIAS 337 359 Lys-rich (basic). FT ACT_SITE 1003 1003 Proton acceptor (By similarity). FT BINDING 908 908 ATP (By similarity). FT MOD_RES 1034 1034 Phosphotyrosine; by autocatalysis (By FT similarity). SQ SEQUENCE 1156 AA; 132246 MW; FF54BDDD2F9666F5 CRC64; MPELAVMELG RQLCGKMKKQ RKAEMTVLTV MKGLEIHFYL PDTHQLEYFK DCHTAEDLCV EGCQEDATSH LCADNLFALS EESQDLWYAP NHAFKITEET SIKLHYRMRF YFTNWHAPVR TESPVWRHSL FKHKGVSVSP KGPEGTPLLD AASLEYLFAQ GQYDFLRGLA PVRAPQNEAE KHEIENECLG MAVLAITHHA KSNDLPLSGV GAETSYKRFI PDSLNRTIKQ RNFSHVYVYN NVFKNFLNEF NSKTIQDSNI TLYDLKVKYL STLETLTQGL GRETIEPKIL KVSGESDGSP ALTLPSGDDG LGYEVQVSGT TGISWRRKPV PNILIVKDKT KSKKNKADKQ SKKEMTKRKT VMTIFSDFFE ITHIVIKESC ATIYSQDNKT MELDLFYRDA ALSFAALVDG YFRLTVDAHH YLCTEVAPSS VVQNLENGCH GPICTEYAIH KLRQEGNEEG TYVLRWSCTD YNYIIMTVVC IEMDLCESRP VPQYKNFQIE TSPQGYRLYG TDTFRPTLKE LLEHLQGQNL RTENLRFQPV LVGLGQPRKI SNLLVMTRDR EPDSQRQPQV SQLSFHRILK EEIVQGEHLG RGTRTNIYSG VLKLKSEDDD DMGGYSQEVK VILKVLGSGH RDISLAFFET ASMMRQISHK HIALLYGVCV RHQENIMVEE FVQYGPLDLF MRRQSIPLST AWKFQVAKQL AGALSYLEDK KLVHGNVCSK NILVARDGLD GEGGPFIKLS DPGIPITVLS REECVDRLPW IAPECVQDTA NLSIAADKWG FGTTLWEICY NGEIPLKDKK LTEKERFYAA QCQLASPDCE ELAKLMTHCM TYDPRQRLFF RAIVRDIDMV EKQNPSIQPV PMLEVDPTVF EKRFLKKIRD LGEGHFGKVE LCRYDPRGDR TGELVAVKSL KPENREEQSS NLWREIHILR ELYHENIVKY KGIWHEEGGR SIKLIMEFLP AGSLKEYLPR NKAHIDLKTL LNYAVQICQG MDLLASRNYI HRDLAARNVL VENENTVKIG DFGLTKSIKD NEGYYTVKDD LDSPVFWYAP ECLIHCKFYR ASDVWSFGVT MYELLTYCDI SCSPMSVFLT MIGPTHGQMT VTRLVKVLEE GKRLPKPDGC SDRLYCLMRR CWEATPEKRI DFKGLIANFQ QMIDNQ //