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Q09178 (JAK1_CYPCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase JAK1
EC=2.7.10.2
Alternative name(s):
Janus kinase 1
Short name=JAK-1
Gene names
Name:jak1
OrganismCyprinus carpio (Common carp)
Taxonomic identifier7962 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Cyprinus

Protein attributes

Sequence length1156 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine kinase of the non-receptor type By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Endomembrane system; Peripheral membrane protein By similarity. Note: Wholly intracellular, possibly membrane associated By similarity.

Domain

Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

Contains 1 FERM domain.

Contains 2 protein kinase domains.

Contains 1 SH2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11561156Tyrosine-protein kinase JAK1
PRO_0000088111

Regions

Domain32 – 419388FERM
Domain438 – 543106SH2; atypical
Domain583 – 857275Protein kinase 1
Domain875 – 1153279Protein kinase 2
Nucleotide binding881 – 8899ATP By similarity
Compositional bias337 – 35923Lys-rich (basic)

Sites

Active site10031Proton acceptor By similarity
Binding site9081ATP By similarity

Amino acid modifications

Modified residue10341Phosphotyrosine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09178 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: FF54BDDD2F9666F5

FASTA1,156132,246
        10         20         30         40         50         60 
MPELAVMELG RQLCGKMKKQ RKAEMTVLTV MKGLEIHFYL PDTHQLEYFK DCHTAEDLCV 

        70         80         90        100        110        120 
EGCQEDATSH LCADNLFALS EESQDLWYAP NHAFKITEET SIKLHYRMRF YFTNWHAPVR 

       130        140        150        160        170        180 
TESPVWRHSL FKHKGVSVSP KGPEGTPLLD AASLEYLFAQ GQYDFLRGLA PVRAPQNEAE 

       190        200        210        220        230        240 
KHEIENECLG MAVLAITHHA KSNDLPLSGV GAETSYKRFI PDSLNRTIKQ RNFSHVYVYN 

       250        260        270        280        290        300 
NVFKNFLNEF NSKTIQDSNI TLYDLKVKYL STLETLTQGL GRETIEPKIL KVSGESDGSP 

       310        320        330        340        350        360 
ALTLPSGDDG LGYEVQVSGT TGISWRRKPV PNILIVKDKT KSKKNKADKQ SKKEMTKRKT 

       370        380        390        400        410        420 
VMTIFSDFFE ITHIVIKESC ATIYSQDNKT MELDLFYRDA ALSFAALVDG YFRLTVDAHH 

       430        440        450        460        470        480 
YLCTEVAPSS VVQNLENGCH GPICTEYAIH KLRQEGNEEG TYVLRWSCTD YNYIIMTVVC 

       490        500        510        520        530        540 
IEMDLCESRP VPQYKNFQIE TSPQGYRLYG TDTFRPTLKE LLEHLQGQNL RTENLRFQPV 

       550        560        570        580        590        600 
LVGLGQPRKI SNLLVMTRDR EPDSQRQPQV SQLSFHRILK EEIVQGEHLG RGTRTNIYSG 

       610        620        630        640        650        660 
VLKLKSEDDD DMGGYSQEVK VILKVLGSGH RDISLAFFET ASMMRQISHK HIALLYGVCV 

       670        680        690        700        710        720 
RHQENIMVEE FVQYGPLDLF MRRQSIPLST AWKFQVAKQL AGALSYLEDK KLVHGNVCSK 

       730        740        750        760        770        780 
NILVARDGLD GEGGPFIKLS DPGIPITVLS REECVDRLPW IAPECVQDTA NLSIAADKWG 

       790        800        810        820        830        840 
FGTTLWEICY NGEIPLKDKK LTEKERFYAA QCQLASPDCE ELAKLMTHCM TYDPRQRLFF 

       850        860        870        880        890        900 
RAIVRDIDMV EKQNPSIQPV PMLEVDPTVF EKRFLKKIRD LGEGHFGKVE LCRYDPRGDR 

       910        920        930        940        950        960 
TGELVAVKSL KPENREEQSS NLWREIHILR ELYHENIVKY KGIWHEEGGR SIKLIMEFLP 

       970        980        990       1000       1010       1020 
AGSLKEYLPR NKAHIDLKTL LNYAVQICQG MDLLASRNYI HRDLAARNVL VENENTVKIG 

      1030       1040       1050       1060       1070       1080 
DFGLTKSIKD NEGYYTVKDD LDSPVFWYAP ECLIHCKFYR ASDVWSFGVT MYELLTYCDI 

      1090       1100       1110       1120       1130       1140 
SCSPMSVFLT MIGPTHGQMT VTRLVKVLEE GKRLPKPDGC SDRLYCLMRR CWEATPEKRI 

      1150 
DFKGLIANFQ QMIDNQ

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References

[1]"Expression, characterization, and genomic structure of carp JAK1 kinase gene."
Chang M.S., Chang G.D., Leu J.H., Huang F.L., Chou C.K., Huang C.J., Lo T.B.
DNA Cell Biol. 15:827-844(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L24895 mRNA. Translation: AAB38157.1.
U53694 expand/collapse EMBL AC list , U53686, U53687, U53688, U53689, U53690, U53691, U53692, U53693 Genomic DNA. Translation: AAB38256.1.

3D structure databases

ProteinModelPortalQ09178.
SMRQ09178. Positions 870-1154.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006195.

Enzyme and pathway databases

BRENDA2.7.10.2. 1195.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776. Tyr_kinase_non-rcpt_Jak1.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSPR01823. JANUSKINASE.
PR01824. JANUSKINASE1.
PR00109. TYRKINASE.
SMARTSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMSSF47031. FERM_3-hlx. 1 hit.
SSF56112. Kinase_like. 2 hits.
PROSITEPS00660. FERM_1. False negative.
PS00661. FERM_2. False negative.
PS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJAK1_CYPCA
AccessionPrimary (citable) accession number: Q09178
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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