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Q09178

- JAK1_CYPCA

UniProt

Q09178 - JAK1_CYPCA

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Protein

Tyrosine-protein kinase JAK1

Gene
jak1
Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Tyrosine kinase of the non-receptor type By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei908 – 9081ATP By similarity
Active sitei1003 – 10031Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi881 – 8899ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1195.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase JAK1 (EC:2.7.10.2)
Alternative name(s):
Janus kinase 1
Short name:
JAK-1
Gene namesi
Name:jak1
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Subcellular locationi

Endomembrane system; Peripheral membrane protein By similarity
Note: Wholly intracellular, possibly membrane associated By similarity.

GO - Cellular componenti

  1. cytoskeleton Source: InterPro
  2. endomembrane system Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11561156Tyrosine-protein kinase JAK1PRO_0000088111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1034 – 10341Phosphotyrosine; by autocatalysis By similarity
Modified residuei1035 – 10351Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ09178.
SMRiQ09178. Positions 870-1154.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 419388FERMAdd
BLAST
Domaini438 – 543106SH2; atypicalAdd
BLAST
Domaini583 – 857275Protein kinase 1Add
BLAST
Domaini875 – 1153279Protein kinase 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi337 – 35923Lys-rich (basic)Add
BLAST

Domaini

Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.

Sequence similaritiesi

Contains 1 FERM domain.
Contains 1 SH2 domain.

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

HOVERGENiHBG006195.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776. Tyr_kinase_non-rcpt_Jak1.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR01824. JANUSKINASE1.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09178-1 [UniParc]FASTAAdd to Basket

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MPELAVMELG RQLCGKMKKQ RKAEMTVLTV MKGLEIHFYL PDTHQLEYFK     50
DCHTAEDLCV EGCQEDATSH LCADNLFALS EESQDLWYAP NHAFKITEET 100
SIKLHYRMRF YFTNWHAPVR TESPVWRHSL FKHKGVSVSP KGPEGTPLLD 150
AASLEYLFAQ GQYDFLRGLA PVRAPQNEAE KHEIENECLG MAVLAITHHA 200
KSNDLPLSGV GAETSYKRFI PDSLNRTIKQ RNFSHVYVYN NVFKNFLNEF 250
NSKTIQDSNI TLYDLKVKYL STLETLTQGL GRETIEPKIL KVSGESDGSP 300
ALTLPSGDDG LGYEVQVSGT TGISWRRKPV PNILIVKDKT KSKKNKADKQ 350
SKKEMTKRKT VMTIFSDFFE ITHIVIKESC ATIYSQDNKT MELDLFYRDA 400
ALSFAALVDG YFRLTVDAHH YLCTEVAPSS VVQNLENGCH GPICTEYAIH 450
KLRQEGNEEG TYVLRWSCTD YNYIIMTVVC IEMDLCESRP VPQYKNFQIE 500
TSPQGYRLYG TDTFRPTLKE LLEHLQGQNL RTENLRFQPV LVGLGQPRKI 550
SNLLVMTRDR EPDSQRQPQV SQLSFHRILK EEIVQGEHLG RGTRTNIYSG 600
VLKLKSEDDD DMGGYSQEVK VILKVLGSGH RDISLAFFET ASMMRQISHK 650
HIALLYGVCV RHQENIMVEE FVQYGPLDLF MRRQSIPLST AWKFQVAKQL 700
AGALSYLEDK KLVHGNVCSK NILVARDGLD GEGGPFIKLS DPGIPITVLS 750
REECVDRLPW IAPECVQDTA NLSIAADKWG FGTTLWEICY NGEIPLKDKK 800
LTEKERFYAA QCQLASPDCE ELAKLMTHCM TYDPRQRLFF RAIVRDIDMV 850
EKQNPSIQPV PMLEVDPTVF EKRFLKKIRD LGEGHFGKVE LCRYDPRGDR 900
TGELVAVKSL KPENREEQSS NLWREIHILR ELYHENIVKY KGIWHEEGGR 950
SIKLIMEFLP AGSLKEYLPR NKAHIDLKTL LNYAVQICQG MDLLASRNYI 1000
HRDLAARNVL VENENTVKIG DFGLTKSIKD NEGYYTVKDD LDSPVFWYAP 1050
ECLIHCKFYR ASDVWSFGVT MYELLTYCDI SCSPMSVFLT MIGPTHGQMT 1100
VTRLVKVLEE GKRLPKPDGC SDRLYCLMRR CWEATPEKRI DFKGLIANFQ 1150
QMIDNQ 1156
Length:1,156
Mass (Da):132,246
Last modified:October 1, 1996 - v1
Checksum:iFF54BDDD2F9666F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24895 mRNA. Translation: AAB38157.1.
U53694
, U53686, U53687, U53688, U53689, U53690, U53691, U53692, U53693 Genomic DNA. Translation: AAB38256.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24895 mRNA. Translation: AAB38157.1 .
U53694
, U53686 , U53687 , U53688 , U53689 , U53690 , U53691 , U53692 , U53693 Genomic DNA. Translation: AAB38256.1 .

3D structure databases

ProteinModelPortali Q09178.
SMRi Q09178. Positions 870-1154.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006195.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1195.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776. Tyr_kinase_non-rcpt_Jak1.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 2 hits.
[Graphical view ]
PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
PRINTSi PR01823. JANUSKINASE.
PR01824. JANUSKINASE1.
PR00109. TYRKINASE.
SMARTi SM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression, characterization, and genomic structure of carp JAK1 kinase gene."
    Chang M.S., Chang G.D., Leu J.H., Huang F.L., Chou C.K., Huang C.J., Lo T.B.
    DNA Cell Biol. 15:827-844(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiJAK1_CYPCA
AccessioniPrimary (citable) accession number: Q09178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi