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Protein

Tyrosine-protein kinase JAK1

Gene

jak1

Organism
Cyprinus carpio (Common carp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tyrosine kinase of the non-receptor type.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei908 – 9081ATPPROSITE-ProRule annotation
Active sitei1003 – 10031Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi881 – 8899ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1195.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase JAK1 (EC:2.7.10.2)
Alternative name(s):
Janus kinase 1
Short name:
JAK-1
Gene namesi
Name:jak1
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Subcellular locationi

Endomembrane system By similarity; Peripheral membrane protein By similarity
Note: Wholly intracellular, possibly membrane associated.By similarity

GO - Cellular componenti

  1. cytoskeleton Source: InterPro
  2. endomembrane system Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11561156Tyrosine-protein kinase JAK1PRO_0000088111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1034 – 10341Phosphotyrosine; by autocatalysisBy similarity
Modified residuei1035 – 10351Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ09178.
SMRiQ09178. Positions 870-1154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 419388FERMPROSITE-ProRule annotationAdd
BLAST
Domaini438 – 543106SH2; atypicalAdd
BLAST
Domaini583 – 857275Protein kinase 1PROSITE-ProRule annotationAdd
BLAST
Domaini875 – 1153279Protein kinase 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi337 – 35923Lys-rich (basic)Add
BLAST

Domaini

Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 2 protein kinase domains.PROSITE-ProRule annotation
Contains 1 SH2 domain.Curated

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

HOVERGENiHBG006195.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776. Tyr_kinase_non-rcpt_Jak1.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR01824. JANUSKINASE1.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELAVMELG RQLCGKMKKQ RKAEMTVLTV MKGLEIHFYL PDTHQLEYFK
60 70 80 90 100
DCHTAEDLCV EGCQEDATSH LCADNLFALS EESQDLWYAP NHAFKITEET
110 120 130 140 150
SIKLHYRMRF YFTNWHAPVR TESPVWRHSL FKHKGVSVSP KGPEGTPLLD
160 170 180 190 200
AASLEYLFAQ GQYDFLRGLA PVRAPQNEAE KHEIENECLG MAVLAITHHA
210 220 230 240 250
KSNDLPLSGV GAETSYKRFI PDSLNRTIKQ RNFSHVYVYN NVFKNFLNEF
260 270 280 290 300
NSKTIQDSNI TLYDLKVKYL STLETLTQGL GRETIEPKIL KVSGESDGSP
310 320 330 340 350
ALTLPSGDDG LGYEVQVSGT TGISWRRKPV PNILIVKDKT KSKKNKADKQ
360 370 380 390 400
SKKEMTKRKT VMTIFSDFFE ITHIVIKESC ATIYSQDNKT MELDLFYRDA
410 420 430 440 450
ALSFAALVDG YFRLTVDAHH YLCTEVAPSS VVQNLENGCH GPICTEYAIH
460 470 480 490 500
KLRQEGNEEG TYVLRWSCTD YNYIIMTVVC IEMDLCESRP VPQYKNFQIE
510 520 530 540 550
TSPQGYRLYG TDTFRPTLKE LLEHLQGQNL RTENLRFQPV LVGLGQPRKI
560 570 580 590 600
SNLLVMTRDR EPDSQRQPQV SQLSFHRILK EEIVQGEHLG RGTRTNIYSG
610 620 630 640 650
VLKLKSEDDD DMGGYSQEVK VILKVLGSGH RDISLAFFET ASMMRQISHK
660 670 680 690 700
HIALLYGVCV RHQENIMVEE FVQYGPLDLF MRRQSIPLST AWKFQVAKQL
710 720 730 740 750
AGALSYLEDK KLVHGNVCSK NILVARDGLD GEGGPFIKLS DPGIPITVLS
760 770 780 790 800
REECVDRLPW IAPECVQDTA NLSIAADKWG FGTTLWEICY NGEIPLKDKK
810 820 830 840 850
LTEKERFYAA QCQLASPDCE ELAKLMTHCM TYDPRQRLFF RAIVRDIDMV
860 870 880 890 900
EKQNPSIQPV PMLEVDPTVF EKRFLKKIRD LGEGHFGKVE LCRYDPRGDR
910 920 930 940 950
TGELVAVKSL KPENREEQSS NLWREIHILR ELYHENIVKY KGIWHEEGGR
960 970 980 990 1000
SIKLIMEFLP AGSLKEYLPR NKAHIDLKTL LNYAVQICQG MDLLASRNYI
1010 1020 1030 1040 1050
HRDLAARNVL VENENTVKIG DFGLTKSIKD NEGYYTVKDD LDSPVFWYAP
1060 1070 1080 1090 1100
ECLIHCKFYR ASDVWSFGVT MYELLTYCDI SCSPMSVFLT MIGPTHGQMT
1110 1120 1130 1140 1150
VTRLVKVLEE GKRLPKPDGC SDRLYCLMRR CWEATPEKRI DFKGLIANFQ

QMIDNQ
Length:1,156
Mass (Da):132,246
Last modified:October 1, 1996 - v1
Checksum:iFF54BDDD2F9666F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24895 mRNA. Translation: AAB38157.1.
U53694
, U53686, U53687, U53688, U53689, U53690, U53691, U53692, U53693 Genomic DNA. Translation: AAB38256.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24895 mRNA. Translation: AAB38157.1.
U53694
, U53686, U53687, U53688, U53689, U53690, U53691, U53692, U53693 Genomic DNA. Translation: AAB38256.1.

3D structure databases

ProteinModelPortaliQ09178.
SMRiQ09178. Positions 870-1154.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006195.

Enzyme and pathway databases

BRENDAi2.7.10.2. 1195.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776. Tyr_kinase_non-rcpt_Jak1.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR01824. JANUSKINASE1.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression, characterization, and genomic structure of carp JAK1 kinase gene."
    Chang M.S., Chang G.D., Leu J.H., Huang F.L., Chou C.K., Huang C.J., Lo T.B.
    DNA Cell Biol. 15:827-844(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiJAK1_CYPCA
AccessioniPrimary (citable) accession number: Q09178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.