Reviewed,
UniProtKB/Swiss-Prot Q09178 (JAK1_CYPCA)
Last modified
June 16, 2009.
Version 75.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Tyrosine-protein kinase Jak1 EC=2.7.10.2 Alternative name(s): Janus kinase 1 Short name=Jak-1 | ||
| Gene names |
| ||
| Organism | Cyprinus carpio (Common carp) | ||
| Taxonomic identifier | 7962 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Cyprinus |
Protein attributes
| Sequence length | 1156 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Tyrosine kinase of the non-receptor type By similarity. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subcellular location | Endomembrane system; Peripheral membrane protein By similarity. Note: Wholly intracellular, possibly membrane associated By similarity. |
| Domain | Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 1 protein kinase domain. Contains 1 SH2 domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Repeat SH2 domain |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase Tyrosine-protein kinase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoskeleton Inferred from electronic annotation. Source: InterPro endomembrane systemInferred from electronic annotation. Source: UniProtKB-SubCell membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW Janus kinase activityInferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activityInferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1156 | 1156 | Tyrosine-protein kinase Jak1 | PRO_0000088111 | |||||
Regions | |||||||||
| Domain | 32 – 419 | 388 | FERM | ||||||
| Domain | 438 – 543 | 106 | SH2; atypical | ||||||
| Domain | 583 – 857 | 275 | Protein kinase 1 | ||||||
| Domain | 875 – 1153 | 279 | Protein kinase 2 | ||||||
| Nucleotide binding | 881 – 889 | 9 | ATP By similarity | ||||||
| Compositional bias | 337 – 359 | 23 | Lys-rich (basic) | ||||||
Sites | |||||||||
| Active site | 1003 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 908 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1034 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
Sequences
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References
| [1] | "Expression, characterization, and genomic structure of carp JAK1 kinase gene." Chang M.S., Chang G.D., Leu J.H., Huang F.L., Chou C.K., Huang C.J., Lo T.B. DNA Cell Biol. 15:827-844(1996) [PubMed: 8892755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| L24895 mRNA. Translation: AAB38157.1. U53694  U53693 Genomic DNA. Translation: AAB38256.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FGK based on UniProtKB P11362. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | Q09178. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.2. 3298. |
Family and domain databases | |
| InterPro | IPR019749. Band_41_domain. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR009127. JAK. IPR009128. JAK1. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. IPR016251. TyrPK_Jak. [Graphical view] |
| Pfam | PF07714. Pkinase_Tyr. 2 hits. [Graphical view] |
| PIRSF | PIRSF000636. TyrPK_Jak. 1 hit. |
| PRINTS | PR01823. JANUSKINASE. PR01824. JANUSKINASE1. PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 2 hits. PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00295. B41. 1 hit. SM00252. SH2. 1 hit. SM00219. TyrKc. 2 hits. [Graphical view] |
| PROSITE | PS00660. FERM_1. False negative. PS00661. FERM_2. False negative. PS50057. FERM_3. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 2 hits. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | JAK1_CYPCA | ||||||||
| Accession | Primary (citable) accession number: Q09178 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
