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Protein

Tyrosine-protein kinase JAK1

Gene

jak1

Organism
Cyprinus carpio (Common carp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tyrosine kinase of the non-receptor type.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Mg2+CuratedNote: Mn2+ was used in the in vitro kinase assay but Mg2+ is likely to be the in vivo cofactor.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei908ATPPROSITE-ProRule annotation1
Active sitei1003Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi881 – 889ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1195.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase JAK1 (EC:2.7.10.2)
Alternative name(s):
Janus kinase 1
Short name:
JAK-1
Gene namesi
Name:jak1
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881111 – 1156Tyrosine-protein kinase JAK1Add BLAST1156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1034Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1035Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ09178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 419FERMPROSITE-ProRule annotationAdd BLAST388
Domaini438 – 543SH2; atypicalAdd BLAST106
Domaini583 – 857Protein kinase 1PROSITE-ProRule annotationAdd BLAST275
Domaini875 – 1153Protein kinase 2PROSITE-ProRule annotationAdd BLAST279

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi337 – 359Lys-rich (basic)Add BLAST23

Domaini

Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 2 protein kinase domains.PROSITE-ProRule annotation
Contains 1 SH2 domain.Curated

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

HOVERGENiHBG006195.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776. Tyr_kinase_non-rcpt_Jak1.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR01824. JANUSKINASE1.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELAVMELG RQLCGKMKKQ RKAEMTVLTV MKGLEIHFYL PDTHQLEYFK
60 70 80 90 100
DCHTAEDLCV EGCQEDATSH LCADNLFALS EESQDLWYAP NHAFKITEET
110 120 130 140 150
SIKLHYRMRF YFTNWHAPVR TESPVWRHSL FKHKGVSVSP KGPEGTPLLD
160 170 180 190 200
AASLEYLFAQ GQYDFLRGLA PVRAPQNEAE KHEIENECLG MAVLAITHHA
210 220 230 240 250
KSNDLPLSGV GAETSYKRFI PDSLNRTIKQ RNFSHVYVYN NVFKNFLNEF
260 270 280 290 300
NSKTIQDSNI TLYDLKVKYL STLETLTQGL GRETIEPKIL KVSGESDGSP
310 320 330 340 350
ALTLPSGDDG LGYEVQVSGT TGISWRRKPV PNILIVKDKT KSKKNKADKQ
360 370 380 390 400
SKKEMTKRKT VMTIFSDFFE ITHIVIKESC ATIYSQDNKT MELDLFYRDA
410 420 430 440 450
ALSFAALVDG YFRLTVDAHH YLCTEVAPSS VVQNLENGCH GPICTEYAIH
460 470 480 490 500
KLRQEGNEEG TYVLRWSCTD YNYIIMTVVC IEMDLCESRP VPQYKNFQIE
510 520 530 540 550
TSPQGYRLYG TDTFRPTLKE LLEHLQGQNL RTENLRFQPV LVGLGQPRKI
560 570 580 590 600
SNLLVMTRDR EPDSQRQPQV SQLSFHRILK EEIVQGEHLG RGTRTNIYSG
610 620 630 640 650
VLKLKSEDDD DMGGYSQEVK VILKVLGSGH RDISLAFFET ASMMRQISHK
660 670 680 690 700
HIALLYGVCV RHQENIMVEE FVQYGPLDLF MRRQSIPLST AWKFQVAKQL
710 720 730 740 750
AGALSYLEDK KLVHGNVCSK NILVARDGLD GEGGPFIKLS DPGIPITVLS
760 770 780 790 800
REECVDRLPW IAPECVQDTA NLSIAADKWG FGTTLWEICY NGEIPLKDKK
810 820 830 840 850
LTEKERFYAA QCQLASPDCE ELAKLMTHCM TYDPRQRLFF RAIVRDIDMV
860 870 880 890 900
EKQNPSIQPV PMLEVDPTVF EKRFLKKIRD LGEGHFGKVE LCRYDPRGDR
910 920 930 940 950
TGELVAVKSL KPENREEQSS NLWREIHILR ELYHENIVKY KGIWHEEGGR
960 970 980 990 1000
SIKLIMEFLP AGSLKEYLPR NKAHIDLKTL LNYAVQICQG MDLLASRNYI
1010 1020 1030 1040 1050
HRDLAARNVL VENENTVKIG DFGLTKSIKD NEGYYTVKDD LDSPVFWYAP
1060 1070 1080 1090 1100
ECLIHCKFYR ASDVWSFGVT MYELLTYCDI SCSPMSVFLT MIGPTHGQMT
1110 1120 1130 1140 1150
VTRLVKVLEE GKRLPKPDGC SDRLYCLMRR CWEATPEKRI DFKGLIANFQ

QMIDNQ
Length:1,156
Mass (Da):132,246
Last modified:October 1, 1996 - v1
Checksum:iFF54BDDD2F9666F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24895 mRNA. Translation: AAB38157.1.
U53694
, U53686, U53687, U53688, U53689, U53690, U53691, U53692, U53693 Genomic DNA. Translation: AAB38256.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24895 mRNA. Translation: AAB38157.1.
U53694
, U53686, U53687, U53688, U53689, U53690, U53691, U53692, U53693 Genomic DNA. Translation: AAB38256.1.

3D structure databases

ProteinModelPortaliQ09178.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006195.

Enzyme and pathway databases

BRENDAi2.7.10.2. 1195.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776. Tyr_kinase_non-rcpt_Jak1.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR01824. JANUSKINASE1.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJAK1_CYPCA
AccessioniPrimary (citable) accession number: Q09178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.