Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q09178

- JAK1_CYPCA

UniProt

Q09178 - JAK1_CYPCA

Protein

Tyrosine-protein kinase JAK1

Gene

jak1

Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Tyrosine kinase of the non-receptor type.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei908 – 9081ATPPROSITE-ProRule annotation
    Active sitei1003 – 10031Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi881 – 8899ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1195.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase JAK1 (EC:2.7.10.2)
    Alternative name(s):
    Janus kinase 1
    Short name:
    JAK-1
    Gene namesi
    Name:jak1
    OrganismiCyprinus carpio (Common carp)
    Taxonomic identifieri7962 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

    Subcellular locationi

    Endomembrane system By similarity; Peripheral membrane protein By similarity
    Note: Wholly intracellular, possibly membrane associated.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: InterPro
    2. endomembrane system Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11561156Tyrosine-protein kinase JAK1PRO_0000088111Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1034 – 10341Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei1035 – 10351Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ09178.
    SMRiQ09178. Positions 870-1154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 419388FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini438 – 543106SH2; atypicalAdd
    BLAST
    Domaini583 – 857275Protein kinase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini875 – 1153279Protein kinase 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi337 – 35923Lys-rich (basic)Add
    BLAST

    Domaini

    Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 2 protein kinase domains.PROSITE-ProRule annotation
    Contains 1 SH2 domain.Curated

    Keywords - Domaini

    Repeat, SH2 domain

    Phylogenomic databases

    HOVERGENiHBG006195.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR020776. Tyr_kinase_non-rcpt_Jak1.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSiPR01823. JANUSKINASE.
    PR01824. JANUSKINASE1.
    PR00109. TYRKINASE.
    SMARTiSM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09178-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPELAVMELG RQLCGKMKKQ RKAEMTVLTV MKGLEIHFYL PDTHQLEYFK     50
    DCHTAEDLCV EGCQEDATSH LCADNLFALS EESQDLWYAP NHAFKITEET 100
    SIKLHYRMRF YFTNWHAPVR TESPVWRHSL FKHKGVSVSP KGPEGTPLLD 150
    AASLEYLFAQ GQYDFLRGLA PVRAPQNEAE KHEIENECLG MAVLAITHHA 200
    KSNDLPLSGV GAETSYKRFI PDSLNRTIKQ RNFSHVYVYN NVFKNFLNEF 250
    NSKTIQDSNI TLYDLKVKYL STLETLTQGL GRETIEPKIL KVSGESDGSP 300
    ALTLPSGDDG LGYEVQVSGT TGISWRRKPV PNILIVKDKT KSKKNKADKQ 350
    SKKEMTKRKT VMTIFSDFFE ITHIVIKESC ATIYSQDNKT MELDLFYRDA 400
    ALSFAALVDG YFRLTVDAHH YLCTEVAPSS VVQNLENGCH GPICTEYAIH 450
    KLRQEGNEEG TYVLRWSCTD YNYIIMTVVC IEMDLCESRP VPQYKNFQIE 500
    TSPQGYRLYG TDTFRPTLKE LLEHLQGQNL RTENLRFQPV LVGLGQPRKI 550
    SNLLVMTRDR EPDSQRQPQV SQLSFHRILK EEIVQGEHLG RGTRTNIYSG 600
    VLKLKSEDDD DMGGYSQEVK VILKVLGSGH RDISLAFFET ASMMRQISHK 650
    HIALLYGVCV RHQENIMVEE FVQYGPLDLF MRRQSIPLST AWKFQVAKQL 700
    AGALSYLEDK KLVHGNVCSK NILVARDGLD GEGGPFIKLS DPGIPITVLS 750
    REECVDRLPW IAPECVQDTA NLSIAADKWG FGTTLWEICY NGEIPLKDKK 800
    LTEKERFYAA QCQLASPDCE ELAKLMTHCM TYDPRQRLFF RAIVRDIDMV 850
    EKQNPSIQPV PMLEVDPTVF EKRFLKKIRD LGEGHFGKVE LCRYDPRGDR 900
    TGELVAVKSL KPENREEQSS NLWREIHILR ELYHENIVKY KGIWHEEGGR 950
    SIKLIMEFLP AGSLKEYLPR NKAHIDLKTL LNYAVQICQG MDLLASRNYI 1000
    HRDLAARNVL VENENTVKIG DFGLTKSIKD NEGYYTVKDD LDSPVFWYAP 1050
    ECLIHCKFYR ASDVWSFGVT MYELLTYCDI SCSPMSVFLT MIGPTHGQMT 1100
    VTRLVKVLEE GKRLPKPDGC SDRLYCLMRR CWEATPEKRI DFKGLIANFQ 1150
    QMIDNQ 1156
    Length:1,156
    Mass (Da):132,246
    Last modified:October 1, 1996 - v1
    Checksum:iFF54BDDD2F9666F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24895 mRNA. Translation: AAB38157.1.
    U53694
    , U53686, U53687, U53688, U53689, U53690, U53691, U53692, U53693 Genomic DNA. Translation: AAB38256.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24895 mRNA. Translation: AAB38157.1 .
    U53694
    , U53686 , U53687 , U53688 , U53689 , U53690 , U53691 , U53692 , U53693 Genomic DNA. Translation: AAB38256.1 .

    3D structure databases

    ProteinModelPortali Q09178.
    SMRi Q09178. Positions 870-1154.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006195.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1195.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR020776. Tyr_kinase_non-rcpt_Jak1.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSi PR01823. JANUSKINASE.
    PR01824. JANUSKINASE1.
    PR00109. TYRKINASE.
    SMARTi SM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression, characterization, and genomic structure of carp JAK1 kinase gene."
      Chang M.S., Chang G.D., Leu J.H., Huang F.L., Chou C.K., Huang C.J., Lo T.B.
      DNA Cell Biol. 15:827-844(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

    Entry informationi

    Entry nameiJAK1_CYPCA
    AccessioniPrimary (citable) accession number: Q09178
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3