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Protein

Protein phosphatase 2C homolog 3

Gene

ptc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Manganese 1By similarity
Metal bindingi62 – 621Manganese 2By similarity
Metal bindingi63 – 631Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi230 – 2301Manganese 2By similarity
Metal bindingi279 – 2791Manganese 2By similarity

GO - Molecular functioni

GO - Biological processi

  • inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
  • protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 3 (EC:3.1.3.16)
Short name:
PP2C-3
Gene namesi
Name:ptc3
ORF Names:SPAC2G11.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2G11.07c.
PomBaseiSPAC2G11.07c. ptc3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Protein phosphatase 2C homolog 3PRO_0000057772Add
BLAST

Proteomic databases

MaxQBiQ09173.
PaxDbiQ09173.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi278491. 54 interactions.
MINTiMINT-4693731.
STRINGi4896.SPAC2G11.07c.1.

Structurei

3D structure databases

ProteinModelPortaliQ09173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 288266PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ09173.
KOiK14803.
OMAiNQISERV.
OrthoDBiEOG79930T.
PhylomeDBiQ09173.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTLSEPVT EKHSVNGSNE FVLYGLSSMQ GWRISMEDAH SAILSMECSA
60 70 80 90 100
VKDPVDFFAV YDGHGGDKVA KWCGSNLPQI LEKNPDFQKG DFVNALKSSF
110 120 130 140 150
LNADKAILDD DQFHTDPSGC TATVVLRVGN KLYCANAGDS RTVLGSKGIA
160 170 180 190 200
KPLSADHKPS NEAEKARICA AGGFVDFGRV NGNLALSRAI GDFEFKNSNL
210 220 230 240 250
EPEKQIVTAL PDVVVHEITD DDEFVVLACD GIWDCKTSQQ VIEFVRRGIV
260 270 280 290 300
AGTSLEKIAE NLMDNCIASD TETTGLGCDN MTVCIVALLQ ENDKSAWYKK
310 320 330 340 350
IADRVAANDG PCAPPEYAEN HGPGWRSGDN NKKVIVPPNF HQVKLNGSDG
360 370 380 390 400
YDKDANENSK EDDSTNGSLA AGFRWKEHFF PHKAEEENSS SETDIVNSNK
410
DVADDHKEAV SAAD
Length:414
Mass (Da):44,857
Last modified:November 1, 1995 - v1
Checksum:iEFF3A416625A2B11
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961K → T in AAA67321 (PubMed:7859738).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34882 Genomic DNA. Translation: AAA67321.1.
CU329670 Genomic DNA. Translation: CAA91172.1.
PIRiT38573. S62462.
RefSeqiNP_593087.1. NM_001018485.2.

Genome annotation databases

EnsemblFungiiSPAC2G11.07c.1; SPAC2G11.07c.1:pep; SPAC2G11.07c.
GeneIDi2542008.
KEGGispo:SPAC2G11.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34882 Genomic DNA. Translation: AAA67321.1.
CU329670 Genomic DNA. Translation: CAA91172.1.
PIRiT38573. S62462.
RefSeqiNP_593087.1. NM_001018485.2.

3D structure databases

ProteinModelPortaliQ09173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278491. 54 interactions.
MINTiMINT-4693731.
STRINGi4896.SPAC2G11.07c.1.

Proteomic databases

MaxQBiQ09173.
PaxDbiQ09173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC2G11.07c.1; SPAC2G11.07c.1:pep; SPAC2G11.07c.
GeneIDi2542008.
KEGGispo:SPAC2G11.07c.

Organism-specific databases

EuPathDBiFungiDB:SPAC2G11.07c.
PomBaseiSPAC2G11.07c. ptc3.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ09173.
KOiK14803.
OMAiNQISERV.
OrthoDBiEOG79930T.
PhylomeDBiQ09173.

Miscellaneous databases

NextBioi20803088.
PROiQ09173.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast."
    Shiozaki K., Russell P.
    EMBO J. 14:492-502(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPP2C3_SCHPO
AccessioniPrimary (citable) accession number: Q09173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.