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Protein

Protein phosphatase 2C homolog 3

Gene

ptc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Manganese 1By similarity1
Metal bindingi62Manganese 2By similarity1
Metal bindingi63Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi230Manganese 2By similarity1
Metal bindingi279Manganese 2By similarity1

GO - Molecular functioni

  • MAP kinase serine/threonine phosphatase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: PomBase

GO - Biological processi

  • cellular response to osmotic stress Source: PomBase
  • negative regulation of stress-activated MAPK cascade Source: PomBase
  • regulation of cellular response to heat Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 3 (EC:3.1.3.16)
Short name:
PP2C-3
Gene namesi
Name:ptc3
ORF Names:SPAC2G11.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2G11.07c
PomBaseiSPAC2G11.07c ptc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577721 – 414Protein phosphatase 2C homolog 3Add BLAST414

Proteomic databases

MaxQBiQ09173
PaxDbiQ09173
PRIDEiQ09173

PTM databases

iPTMnetiQ09173

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi278491, 54 interactors
STRINGi4896.SPAC2G11.07c.1

Structurei

3D structure databases

ProteinModelPortaliQ09173
SMRiQ09173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 288PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST266

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

HOGENOMiHOG000233896
InParanoidiQ09173
KOiK14803
OMAiAKFAGKH
OrthoDBiEOG092C1UK5
PhylomeDBiQ09173

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q09173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTLSEPVT EKHSVNGSNE FVLYGLSSMQ GWRISMEDAH SAILSMECSA
60 70 80 90 100
VKDPVDFFAV YDGHGGDKVA KWCGSNLPQI LEKNPDFQKG DFVNALKSSF
110 120 130 140 150
LNADKAILDD DQFHTDPSGC TATVVLRVGN KLYCANAGDS RTVLGSKGIA
160 170 180 190 200
KPLSADHKPS NEAEKARICA AGGFVDFGRV NGNLALSRAI GDFEFKNSNL
210 220 230 240 250
EPEKQIVTAL PDVVVHEITD DDEFVVLACD GIWDCKTSQQ VIEFVRRGIV
260 270 280 290 300
AGTSLEKIAE NLMDNCIASD TETTGLGCDN MTVCIVALLQ ENDKSAWYKK
310 320 330 340 350
IADRVAANDG PCAPPEYAEN HGPGWRSGDN NKKVIVPPNF HQVKLNGSDG
360 370 380 390 400
YDKDANENSK EDDSTNGSLA AGFRWKEHFF PHKAEEENSS SETDIVNSNK
410
DVADDHKEAV SAAD
Length:414
Mass (Da):44,857
Last modified:November 1, 1995 - v1
Checksum:iEFF3A416625A2B11
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196K → T in AAA67321 (PubMed:7859738).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34882 Genomic DNA Translation: AAA67321.1
CU329670 Genomic DNA Translation: CAA91172.1
PIRiT38573 S62462
RefSeqiNP_593087.1, NM_001018485.2

Genome annotation databases

EnsemblFungiiSPAC2G11.07c.1; SPAC2G11.07c.1:pep; SPAC2G11.07c
GeneIDi2542008
KEGGispo:SPAC2G11.07c

Similar proteinsi

Entry informationi

Entry nameiPP2C3_SCHPO
AccessioniPrimary (citable) accession number: Q09173
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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