Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q09173

- PP2C3_SCHPO

UniProt

Q09173 - PP2C3_SCHPO

Protein

Protein phosphatase 2C homolog 3

Gene

ptc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621Manganese 1By similarity
    Metal bindingi62 – 621Manganese 2By similarity
    Metal bindingi63 – 631Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi230 – 2301Manganese 2By similarity
    Metal bindingi279 – 2791Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: PomBase

    GO - Biological processi

    1. inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
    2. protein dephosphorylation Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C homolog 3 (EC:3.1.3.16)
    Short name:
    PP2C-3
    Gene namesi
    Name:ptc3
    ORF Names:SPAC2G11.07c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC2G11.07c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414Protein phosphatase 2C homolog 3PRO_0000057772Add
    BLAST

    Proteomic databases

    MaxQBiQ09173.
    PaxDbiQ09173.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi278491. 54 interactions.
    MINTiMINT-4693731.
    STRINGi4896.SPAC2G11.07c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    KOiK04457.
    OMAiDPDINTI.
    OrthoDBiEOG79930T.
    PhylomeDBiQ09173.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09173-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQTLSEPVT EKHSVNGSNE FVLYGLSSMQ GWRISMEDAH SAILSMECSA    50
    VKDPVDFFAV YDGHGGDKVA KWCGSNLPQI LEKNPDFQKG DFVNALKSSF 100
    LNADKAILDD DQFHTDPSGC TATVVLRVGN KLYCANAGDS RTVLGSKGIA 150
    KPLSADHKPS NEAEKARICA AGGFVDFGRV NGNLALSRAI GDFEFKNSNL 200
    EPEKQIVTAL PDVVVHEITD DDEFVVLACD GIWDCKTSQQ VIEFVRRGIV 250
    AGTSLEKIAE NLMDNCIASD TETTGLGCDN MTVCIVALLQ ENDKSAWYKK 300
    IADRVAANDG PCAPPEYAEN HGPGWRSGDN NKKVIVPPNF HQVKLNGSDG 350
    YDKDANENSK EDDSTNGSLA AGFRWKEHFF PHKAEEENSS SETDIVNSNK 400
    DVADDHKEAV SAAD 414
    Length:414
    Mass (Da):44,857
    Last modified:November 1, 1995 - v1
    Checksum:iEFF3A416625A2B11
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961K → T in AAA67321. (PubMed:7859738)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34882 Genomic DNA. Translation: AAA67321.1.
    CU329670 Genomic DNA. Translation: CAA91172.1.
    PIRiT38573. S62462.
    RefSeqiNP_593087.1. NM_001018485.2.

    Genome annotation databases

    EnsemblFungiiSPAC2G11.07c.1; SPAC2G11.07c.1:pep; SPAC2G11.07c.
    GeneIDi2542008.
    KEGGispo:SPAC2G11.07c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34882 Genomic DNA. Translation: AAA67321.1 .
    CU329670 Genomic DNA. Translation: CAA91172.1 .
    PIRi T38573. S62462.
    RefSeqi NP_593087.1. NM_001018485.2.

    3D structure databases

    ProteinModelPortali Q09173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278491. 54 interactions.
    MINTi MINT-4693731.
    STRINGi 4896.SPAC2G11.07c-1.

    Proteomic databases

    MaxQBi Q09173.
    PaxDbi Q09173.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC2G11.07c.1 ; SPAC2G11.07c.1:pep ; SPAC2G11.07c .
    GeneIDi 2542008.
    KEGGi spo:SPAC2G11.07c.

    Organism-specific databases

    PomBasei SPAC2G11.07c.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    KOi K04457.
    OMAi DPDINTI.
    OrthoDBi EOG79930T.
    PhylomeDBi Q09173.

    Miscellaneous databases

    NextBioi 20803088.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast."
      Shiozaki K., Russell P.
      EMBO J. 14:492-502(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPP2C3_SCHPO
    AccessioniPrimary (citable) accession number: Q09173
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3