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Q09173

- PP2C3_SCHPO

UniProt

Q09173 - PP2C3_SCHPO

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Protein

Protein phosphatase 2C homolog 3

Gene
ptc3, SPAC2G11.07c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Manganese 1 By similarity
Metal bindingi62 – 621Manganese 2 By similarity
Metal bindingi63 – 631Manganese 1; via carbonyl oxygen By similarity
Metal bindingi230 – 2301Manganese 2 By similarity
Metal bindingi279 – 2791Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: PomBase

GO - Biological processi

  1. inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
  2. protein dephosphorylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 3 (EC:3.1.3.16)
Short name:
PP2C-3
Gene namesi
Name:ptc3
ORF Names:SPAC2G11.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC2G11.07c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Protein phosphatase 2C homolog 3PRO_0000057772Add
BLAST

Proteomic databases

MaxQBiQ09173.
PaxDbiQ09173.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi278491. 54 interactions.
MINTiMINT-4693731.
STRINGi4896.SPAC2G11.07c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09173.

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
KOiK04457.
OMAiDPDINTI.
OrthoDBiEOG79930T.
PhylomeDBiQ09173.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09173-1 [UniParc]FASTAAdd to Basket

« Hide

MGQTLSEPVT EKHSVNGSNE FVLYGLSSMQ GWRISMEDAH SAILSMECSA    50
VKDPVDFFAV YDGHGGDKVA KWCGSNLPQI LEKNPDFQKG DFVNALKSSF 100
LNADKAILDD DQFHTDPSGC TATVVLRVGN KLYCANAGDS RTVLGSKGIA 150
KPLSADHKPS NEAEKARICA AGGFVDFGRV NGNLALSRAI GDFEFKNSNL 200
EPEKQIVTAL PDVVVHEITD DDEFVVLACD GIWDCKTSQQ VIEFVRRGIV 250
AGTSLEKIAE NLMDNCIASD TETTGLGCDN MTVCIVALLQ ENDKSAWYKK 300
IADRVAANDG PCAPPEYAEN HGPGWRSGDN NKKVIVPPNF HQVKLNGSDG 350
YDKDANENSK EDDSTNGSLA AGFRWKEHFF PHKAEEENSS SETDIVNSNK 400
DVADDHKEAV SAAD 414
Length:414
Mass (Da):44,857
Last modified:November 1, 1995 - v1
Checksum:iEFF3A416625A2B11
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961K → T in AAA67321. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34882 Genomic DNA. Translation: AAA67321.1.
CU329670 Genomic DNA. Translation: CAA91172.1.
PIRiT38573. S62462.
RefSeqiNP_593087.1. NM_001018485.2.

Genome annotation databases

EnsemblFungiiSPAC2G11.07c.1; SPAC2G11.07c.1:pep; SPAC2G11.07c.
GeneIDi2542008.
KEGGispo:SPAC2G11.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34882 Genomic DNA. Translation: AAA67321.1 .
CU329670 Genomic DNA. Translation: CAA91172.1 .
PIRi T38573. S62462.
RefSeqi NP_593087.1. NM_001018485.2.

3D structure databases

ProteinModelPortali Q09173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278491. 54 interactions.
MINTi MINT-4693731.
STRINGi 4896.SPAC2G11.07c-1.

Proteomic databases

MaxQBi Q09173.
PaxDbi Q09173.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC2G11.07c.1 ; SPAC2G11.07c.1:pep ; SPAC2G11.07c .
GeneIDi 2542008.
KEGGi spo:SPAC2G11.07c.

Organism-specific databases

PomBasei SPAC2G11.07c.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
KOi K04457.
OMAi DPDINTI.
OrthoDBi EOG79930T.
PhylomeDBi Q09173.

Miscellaneous databases

NextBioi 20803088.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast."
    Shiozaki K., Russell P.
    EMBO J. 14:492-502(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPP2C3_SCHPO
AccessioniPrimary (citable) accession number: Q09173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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