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Q09172

- PP2C2_SCHPO

UniProt

Q09172 - PP2C2_SCHPO

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Protein
Protein phosphatase 2C homolog 2
Gene
ptc2, SPCC1223.11
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Manganese 1 By similarity
Metal bindingi63 – 631Manganese 2 By similarity
Metal bindingi64 – 641Manganese 1; via carbonyl oxygen By similarity
Metal bindingi233 – 2331Manganese 2 By similarity
Metal bindingi282 – 2821Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: PomBase

GO - Biological processi

  1. cellular response to osmotic stress Source: PomBase
  2. endoplasmic reticulum unfolded protein response Source: PomBase
  3. inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
  4. protein dephosphorylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 2 (EC:3.1.3.16)
Short name:
PP2C-2
Gene namesi
Name:ptc2
ORF Names:SPCC1223.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC1223.11.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Protein phosphatase 2C homolog 2
PRO_0000057771Add
BLAST

Proteomic databases

MaxQBiQ09172.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi275822. 86 interactions.
MINTiMINT-4693715.
STRINGi4896.SPCC1223.11-1.

Structurei

3D structure databases

ProteinModelPortaliQ09172.

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
KOiK14803.
OMAiEFRGPGV.
OrthoDBiEOG79930T.
PhylomeDBiQ09172.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09172-1 [UniParc]FASTAAdd to Basket

« Hide

MGQTLSEPVL DKHSSSGGDR WLHFGVSHMQ GWRISMEDAH CALLNFTDSN    50
SSNPPTSFFG VFDGHGGDRV AKYCRQHLPD IIKSQPSFWK GNYDEALKSG 100
FLAADNALMQ DRDMQEDPSG CTATTALIVD HQVIYCANAG DSRTVLGRKG 150
TAEPLSFDHK PNNDVEKARI TAAGGFIDFG RVNGSLALSR AIGDFEYKKD 200
SSLPPEKQIV TAFPDVVIHN IDPDDEFLIL ACDGIWDCKS SQQVVEFVRR 250
GIVARQSLEV ICENLMDRCI ASNSESCGIG CDNMTICIVA FLHGRGLEDW 300
YNWITQRVNS GEGPCAPPSY AELRGPNTIA DARNLQLEYD HIASHEYGSG 350
DTYDSDSDDE TIAYDRYYLH 370
Length:370
Mass (Da):40,878
Last modified:November 1, 1995 - v1
Checksum:iDBDDB826F440AC50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34881 Genomic DNA. Translation: AAA67320.1.
CU329672 Genomic DNA. Translation: CAA20880.1.
PIRiS54297.
RefSeqiNP_588356.1. NM_001023347.2.

Genome annotation databases

EnsemblFungiiSPCC1223.11.1; SPCC1223.11.1:pep; SPCC1223.11.
GeneIDi2539252.
KEGGispo:SPCC1223.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34881 Genomic DNA. Translation: AAA67320.1 .
CU329672 Genomic DNA. Translation: CAA20880.1 .
PIRi S54297.
RefSeqi NP_588356.1. NM_001023347.2.

3D structure databases

ProteinModelPortali Q09172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275822. 86 interactions.
MINTi MINT-4693715.
STRINGi 4896.SPCC1223.11-1.

Proteomic databases

MaxQBi Q09172.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC1223.11.1 ; SPCC1223.11.1:pep ; SPCC1223.11 .
GeneIDi 2539252.
KEGGi spo:SPCC1223.11.

Organism-specific databases

PomBasei SPCC1223.11.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
KOi K14803.
OMAi EFRGPGV.
OrthoDBi EOG79930T.
PhylomeDBi Q09172.

Miscellaneous databases

NextBioi 20800422.
PROi Q09172.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast."
    Shiozaki K., Russell P.
    EMBO J. 14:492-502(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPP2C2_SCHPO
AccessioniPrimary (citable) accession number: Q09172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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