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Q09172 (PP2C2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 2C homolog 2
Short name=PP2C-2
EC=3.1.3.16
Gene names
Name:ptc2
ORF Names:SPCC1223.11
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subunit structure

Monomer.

Sequence similarities

Belongs to the PP2C family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Protein phosphatase 2C homolog 2
PRO_0000057771

Sites

Metal binding631Manganese 1 By similarity
Metal binding631Manganese 2 By similarity
Metal binding641Manganese 1; via carbonyl oxygen By similarity
Metal binding2331Manganese 2 By similarity
Metal binding2821Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09172 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: DBDDB826F440AC50

FASTA37040,878
        10         20         30         40         50         60 
MGQTLSEPVL DKHSSSGGDR WLHFGVSHMQ GWRISMEDAH CALLNFTDSN SSNPPTSFFG 

        70         80         90        100        110        120 
VFDGHGGDRV AKYCRQHLPD IIKSQPSFWK GNYDEALKSG FLAADNALMQ DRDMQEDPSG 

       130        140        150        160        170        180 
CTATTALIVD HQVIYCANAG DSRTVLGRKG TAEPLSFDHK PNNDVEKARI TAAGGFIDFG 

       190        200        210        220        230        240 
RVNGSLALSR AIGDFEYKKD SSLPPEKQIV TAFPDVVIHN IDPDDEFLIL ACDGIWDCKS 

       250        260        270        280        290        300 
SQQVVEFVRR GIVARQSLEV ICENLMDRCI ASNSESCGIG CDNMTICIVA FLHGRGLEDW 

       310        320        330        340        350        360 
YNWITQRVNS GEGPCAPPSY AELRGPNTIA DARNLQLEYD HIASHEYGSG DTYDSDSDDE 

       370 
TIAYDRYYLH

« Hide

References

« Hide 'large scale' references
[1]"Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast."
Shiozaki K., Russell P.
EMBO J. 14:492-502(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L34881 Genomic DNA. Translation: AAA67320.1.
CU329672 Genomic DNA. Translation: CAA20880.1.
PIRS54297.
RefSeqNP_588356.1. NM_001023347.2.

3D structure databases

ProteinModelPortalQ09172.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4693715.
STRING4896.SPCC1223.11-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC1223.11.1; SPCC1223.11.1:pep; SPCC1223.11.
GeneID2539252.
KEGGspo:SPCC1223.11.

Organism-specific databases

PomBaseSPCC1223.11.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000233896.
KOK14803.
OMAKHLHKYV.
OrthoDBEOG4RFQ28.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. PP2C-related. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800422.

Entry information

Entry namePP2C2_SCHPO
AccessionPrimary (citable) accession number: Q09172
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 29, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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