Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 2C homolog 2

Gene

ptc2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Manganese 1By similarity1
Metal bindingi63Manganese 2By similarity1
Metal bindingi64Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi233Manganese 2By similarity1
Metal bindingi282Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: PomBase

GO - Biological processi

  • cellular response to osmotic stress Source: PomBase
  • endoplasmic reticulum unfolded protein response Source: PomBase
  • inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
  • protein dephosphorylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 2 (EC:3.1.3.16)
Short name:
PP2C-2
Gene namesi
Name:ptc2
ORF Names:SPCC1223.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1223.11.
PomBaseiSPCC1223.11. ptc2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577711 – 370Protein phosphatase 2C homolog 2Add BLAST370

Proteomic databases

MaxQBiQ09172.
PRIDEiQ09172.

PTM databases

SwissPalmiQ09172.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi275822. 86 interactors.
MINTiMINT-4693715.

Structurei

3D structure databases

ProteinModelPortaliQ09172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 291PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233896.
InParanoidiQ09172.
KOiK14803.
OMAiDEWAFEE.
OrthoDBiEOG092C1UK5.
PhylomeDBiQ09172.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTLSEPVL DKHSSSGGDR WLHFGVSHMQ GWRISMEDAH CALLNFTDSN
60 70 80 90 100
SSNPPTSFFG VFDGHGGDRV AKYCRQHLPD IIKSQPSFWK GNYDEALKSG
110 120 130 140 150
FLAADNALMQ DRDMQEDPSG CTATTALIVD HQVIYCANAG DSRTVLGRKG
160 170 180 190 200
TAEPLSFDHK PNNDVEKARI TAAGGFIDFG RVNGSLALSR AIGDFEYKKD
210 220 230 240 250
SSLPPEKQIV TAFPDVVIHN IDPDDEFLIL ACDGIWDCKS SQQVVEFVRR
260 270 280 290 300
GIVARQSLEV ICENLMDRCI ASNSESCGIG CDNMTICIVA FLHGRGLEDW
310 320 330 340 350
YNWITQRVNS GEGPCAPPSY AELRGPNTIA DARNLQLEYD HIASHEYGSG
360 370
DTYDSDSDDE TIAYDRYYLH
Length:370
Mass (Da):40,878
Last modified:November 1, 1995 - v1
Checksum:iDBDDB826F440AC50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34881 Genomic DNA. Translation: AAA67320.1.
CU329672 Genomic DNA. Translation: CAA20880.1.
PIRiS54297.
RefSeqiNP_588356.1. NM_001023347.2.

Genome annotation databases

EnsemblFungiiSPCC1223.11.1; SPCC1223.11.1:pep; SPCC1223.11.
GeneIDi2539252.
KEGGispo:SPCC1223.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34881 Genomic DNA. Translation: AAA67320.1.
CU329672 Genomic DNA. Translation: CAA20880.1.
PIRiS54297.
RefSeqiNP_588356.1. NM_001023347.2.

3D structure databases

ProteinModelPortaliQ09172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275822. 86 interactors.
MINTiMINT-4693715.

PTM databases

SwissPalmiQ09172.

Proteomic databases

MaxQBiQ09172.
PRIDEiQ09172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1223.11.1; SPCC1223.11.1:pep; SPCC1223.11.
GeneIDi2539252.
KEGGispo:SPCC1223.11.

Organism-specific databases

EuPathDBiFungiDB:SPCC1223.11.
PomBaseiSPCC1223.11. ptc2.

Phylogenomic databases

HOGENOMiHOG000233896.
InParanoidiQ09172.
KOiK14803.
OMAiDEWAFEE.
OrthoDBiEOG092C1UK5.
PhylomeDBiQ09172.

Miscellaneous databases

PROiQ09172.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP2C2_SCHPO
AccessioniPrimary (citable) accession number: Q09172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.