Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 2C homolog 2

Gene

ptc2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Manganese 1By similarity
Metal bindingi63 – 631Manganese 2By similarity
Metal bindingi64 – 641Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi233 – 2331Manganese 2By similarity
Metal bindingi282 – 2821Manganese 2By similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: PomBase

GO - Biological processi

  • cellular response to osmotic stress Source: PomBase
  • endoplasmic reticulum unfolded protein response Source: PomBase
  • inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
  • protein dephosphorylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 2 (EC:3.1.3.16)
Short name:
PP2C-2
Gene namesi
Name:ptc2
ORF Names:SPCC1223.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1223.11.
PomBaseiSPCC1223.11. ptc2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Protein phosphatase 2C homolog 2PRO_0000057771Add
BLAST

Proteomic databases

MaxQBiQ09172.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi275822. 86 interactions.
MINTiMINT-4693715.

Structurei

3D structure databases

ProteinModelPortaliQ09172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 291269PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ09172.
KOiK14803.
OMAiDTEMFDN.
OrthoDBiEOG79930T.
PhylomeDBiQ09172.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTLSEPVL DKHSSSGGDR WLHFGVSHMQ GWRISMEDAH CALLNFTDSN
60 70 80 90 100
SSNPPTSFFG VFDGHGGDRV AKYCRQHLPD IIKSQPSFWK GNYDEALKSG
110 120 130 140 150
FLAADNALMQ DRDMQEDPSG CTATTALIVD HQVIYCANAG DSRTVLGRKG
160 170 180 190 200
TAEPLSFDHK PNNDVEKARI TAAGGFIDFG RVNGSLALSR AIGDFEYKKD
210 220 230 240 250
SSLPPEKQIV TAFPDVVIHN IDPDDEFLIL ACDGIWDCKS SQQVVEFVRR
260 270 280 290 300
GIVARQSLEV ICENLMDRCI ASNSESCGIG CDNMTICIVA FLHGRGLEDW
310 320 330 340 350
YNWITQRVNS GEGPCAPPSY AELRGPNTIA DARNLQLEYD HIASHEYGSG
360 370
DTYDSDSDDE TIAYDRYYLH
Length:370
Mass (Da):40,878
Last modified:November 1, 1995 - v1
Checksum:iDBDDB826F440AC50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34881 Genomic DNA. Translation: AAA67320.1.
CU329672 Genomic DNA. Translation: CAA20880.1.
PIRiS54297.
RefSeqiNP_588356.1. NM_001023347.2.

Genome annotation databases

EnsemblFungiiSPCC1223.11.1; SPCC1223.11.1:pep; SPCC1223.11.
GeneIDi2539252.
KEGGispo:SPCC1223.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34881 Genomic DNA. Translation: AAA67320.1.
CU329672 Genomic DNA. Translation: CAA20880.1.
PIRiS54297.
RefSeqiNP_588356.1. NM_001023347.2.

3D structure databases

ProteinModelPortaliQ09172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275822. 86 interactions.
MINTiMINT-4693715.

Proteomic databases

MaxQBiQ09172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1223.11.1; SPCC1223.11.1:pep; SPCC1223.11.
GeneIDi2539252.
KEGGispo:SPCC1223.11.

Organism-specific databases

EuPathDBiFungiDB:SPCC1223.11.
PomBaseiSPCC1223.11. ptc2.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ09172.
KOiK14803.
OMAiDTEMFDN.
OrthoDBiEOG79930T.
PhylomeDBiQ09172.

Miscellaneous databases

NextBioi20800422.
PROiQ09172.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast."
    Shiozaki K., Russell P.
    EMBO J. 14:492-502(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPP2C2_SCHPO
AccessioniPrimary (citable) accession number: Q09172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 22, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.