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Q09172

- PP2C2_SCHPO

UniProt

Q09172 - PP2C2_SCHPO

Protein

Protein phosphatase 2C homolog 2

Gene

ptc2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi63 – 631Manganese 1By similarity
    Metal bindingi63 – 631Manganese 2By similarity
    Metal bindingi64 – 641Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi233 – 2331Manganese 2By similarity
    Metal bindingi282 – 2821Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: PomBase

    GO - Biological processi

    1. cellular response to osmotic stress Source: PomBase
    2. endoplasmic reticulum unfolded protein response Source: PomBase
    3. inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
    4. protein dephosphorylation Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C homolog 2 (EC:3.1.3.16)
    Short name:
    PP2C-2
    Gene namesi
    Name:ptc2
    ORF Names:SPCC1223.11
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC1223.11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Protein phosphatase 2C homolog 2PRO_0000057771Add
    BLAST

    Proteomic databases

    MaxQBiQ09172.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi275822. 86 interactions.
    MINTiMINT-4693715.
    STRINGi4896.SPCC1223.11-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    KOiK14803.
    OMAiEFRGPGV.
    OrthoDBiEOG79930T.
    PhylomeDBiQ09172.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09172-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQTLSEPVL DKHSSSGGDR WLHFGVSHMQ GWRISMEDAH CALLNFTDSN    50
    SSNPPTSFFG VFDGHGGDRV AKYCRQHLPD IIKSQPSFWK GNYDEALKSG 100
    FLAADNALMQ DRDMQEDPSG CTATTALIVD HQVIYCANAG DSRTVLGRKG 150
    TAEPLSFDHK PNNDVEKARI TAAGGFIDFG RVNGSLALSR AIGDFEYKKD 200
    SSLPPEKQIV TAFPDVVIHN IDPDDEFLIL ACDGIWDCKS SQQVVEFVRR 250
    GIVARQSLEV ICENLMDRCI ASNSESCGIG CDNMTICIVA FLHGRGLEDW 300
    YNWITQRVNS GEGPCAPPSY AELRGPNTIA DARNLQLEYD HIASHEYGSG 350
    DTYDSDSDDE TIAYDRYYLH 370
    Length:370
    Mass (Da):40,878
    Last modified:November 1, 1995 - v1
    Checksum:iDBDDB826F440AC50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34881 Genomic DNA. Translation: AAA67320.1.
    CU329672 Genomic DNA. Translation: CAA20880.1.
    PIRiS54297.
    RefSeqiNP_588356.1. NM_001023347.2.

    Genome annotation databases

    EnsemblFungiiSPCC1223.11.1; SPCC1223.11.1:pep; SPCC1223.11.
    GeneIDi2539252.
    KEGGispo:SPCC1223.11.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34881 Genomic DNA. Translation: AAA67320.1 .
    CU329672 Genomic DNA. Translation: CAA20880.1 .
    PIRi S54297.
    RefSeqi NP_588356.1. NM_001023347.2.

    3D structure databases

    ProteinModelPortali Q09172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275822. 86 interactions.
    MINTi MINT-4693715.
    STRINGi 4896.SPCC1223.11-1.

    Proteomic databases

    MaxQBi Q09172.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC1223.11.1 ; SPCC1223.11.1:pep ; SPCC1223.11 .
    GeneIDi 2539252.
    KEGGi spo:SPCC1223.11.

    Organism-specific databases

    PomBasei SPCC1223.11.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    KOi K14803.
    OMAi EFRGPGV.
    OrthoDBi EOG79930T.
    PhylomeDBi Q09172.

    Miscellaneous databases

    NextBioi 20800422.
    PROi Q09172.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast."
      Shiozaki K., Russell P.
      EMBO J. 14:492-502(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPP2C2_SCHPO
    AccessioniPrimary (citable) accession number: Q09172
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3