Q09160 (1A80_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, A-80 alpha chain

Alternative name(s):
Aw-80
HLA class I histocompatibility antigen, A-1 alpha chain
MHC class I antigen A*80

Gene names

Name:	HLA-A
Synonyms:	HLAA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The only allele of A-80 known is A*80:01 which is shown here.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Non-traceable author statement Ref.1. Source: UniProtKB interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	MHC class I receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 365	341	HLA class I histocompatibility antigen, A-80 alpha chain		PRO_0000018832
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 332	24	Helical; Potential
	Topological domain	333 – 365	33	Cytoplasmic Potential
	Domain	209 – 297	89	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	125 ↔ 188		By similarity
	Disulfide bond	227 ↔ 283		By similarity
Natural variations
	Natural variant	121	1	I → M. Corresponds to variant rs1136695 [ dbSNP | Ensembl ].		VAR_056313
	Natural variant	129	1	S → P. Corresponds to variant rs1136700 [ dbSNP | Ensembl ].		VAR_056314
	Natural variant	131	1	G → W. Corresponds to variant rs1136702 [ dbSNP | Ensembl ].		VAR_056315
	Natural variant	133	1	F → L. Corresponds to variant rs1059488 [ dbSNP | Ensembl ].		VAR_056316
	Natural variant	151	1	N → K. Corresponds to variant rs1059509 [ dbSNP | Ensembl ].		VAR_056317
	Natural variant	166	1	I → T. Corresponds to variant rs1059516 [ dbSNP | Ensembl ].		VAR_056318
	Natural variant	169	1	R → H. Corresponds to variant rs1059520 [ dbSNP | Ensembl ].		VAR_056319
	Natural variant	205	1	R → H. Corresponds to variant rs17185861 [ dbSNP | Ensembl ].		VAR_056320

Sequences

	Sequence		Length	Mass (Da)
	Q09160 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: CE1BC1CD60CA8FA8	FASTA	365	40,792
	10 20 30 40 50 60 MAVMPPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDSQFVQF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQEE PEYWDEETRN VKAHSQTNRA NLGTLRGYYN QSEDGSHTIQ 130 140 150 160 170 180 IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQL 190 200 210 220 230 240 RAYLEGECVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL SFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEKR YTCHVQHEGL PEPLTLRWEP 310 320 330 340 350 360 SSQPTIPIVG IIAGLVLLGA VIAGAVVAAV MWRKKSSVRK GGSYSQAASS DSAQGSDVSL TACKV

References

[1]	"Characterization of a new and highly distinguishable HLA-A allele in a Spanish family." Balas A., Garcia-Sanchez F., Gomez-Reino F., Vicario J.L. Immunogenetics 39:452-452(1994) [PubMed: 8188325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*80:01).
[2]	"A sixth family of HLA-A alleles defined by HLA-A*8001." Domena J.D., Hildebrand W.H., Bias W.B., Parham P. Tissue Antigens 42:156-159(1993) [PubMed: 8284791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*80:01).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U03754 mRNA. Translation: AAC04322.1. L18898 mRNA. Translation: AAA17012.1.
IPI	IPI00472736.
PIR	I38439. I59638.
UniGene	Hs.181244. Hs.713441.
3D structure databases
ProteinModelPortal	Q09160.
SMR	Q09160. Positions 25-298.
ModBase	Search...
Protein-protein interaction databases
STRING	Q09160.
Polymorphism databases
DMDM	1168212.
Proteomic databases
PRIDE	Q09160.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000431795; ENSP00000396220; ENSG00000229215. ENST00000431930; ENSP00000406366; ENSG00000229215. ENST00000443552; ENSP00000404678; ENSG00000224320. ENST00000448357; ENSP00000402461; ENSG00000224320.
Organism-specific databases
GeneCards	GC06P029921.
HGNC	HGNC:4931. HLA-A.
MIM	142800. gene.
neXtProt	NX_Q09160.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
Gene expression databases
CleanEx	HS_HLA-A.
Genevestigator	Q09160.
GermOnline	ENSG00000204632. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

1A80_HUMAN

Accession

Primary (citable) accession number: Q09160

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.