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Protein

High affinity cationic amino acid transporter 1

Gene

Slc7a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.1 Publication
(Microbial infection) Acts as a receptor for the ecotropic murine retroviral leukemia virus.1 Publication

GO - Molecular functioni

  • arginine transmembrane transporter activity Source: MGI

GO - Biological processi

  • arginine transport Source: MGI

Keywordsi

Molecular functionReceptor
Biological processAmino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.3.3.1 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-1By similarity
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor
Ecotropic retrovirus receptor1 Publication
Short name:
ERR
Solute carrier family 7 member 1Imported
System Y+ basic amino acid transporter
Gene namesi
Name:Slc7a1Imported
Synonyms:Atrc1, Rec-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88117 Slc7a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 57HelicalSequence analysisAdd BLAST22
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 102CytoplasmicSequence analysisAdd BLAST20
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 162ExtracellularSequence analysisAdd BLAST39
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 239ExtracellularSequence analysisAdd BLAST27
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 280CytoplasmicSequence analysisAdd BLAST20
Transmembranei281 – 300HelicalSequence analysisAdd BLAST20
Topological domaini301 – 330ExtracellularSequence analysisAdd BLAST30
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 377CytoplasmicSequence analysisAdd BLAST26
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 401ExtracellularSequence analysis3
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 485CytoplasmicSequence analysisAdd BLAST63
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 519ExtracellularSequence analysisAdd BLAST13
Transmembranei520 – 544HelicalSequence analysisAdd BLAST25
Topological domaini545 – 552CytoplasmicSequence analysis8
Transmembranei553 – 573HelicalSequence analysisAdd BLAST21
Topological domaini574 – 577ExtracellularSequence analysis4
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 622CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542621 – 622High affinity cationic amino acid transporter 1Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei616PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ09143
PaxDbiQ09143
PeptideAtlasiQ09143
PRIDEiQ09143

PTM databases

iPTMnetiQ09143
PhosphoSitePlusiQ09143
SwissPalmiQ09143

Expressioni

Tissue specificityi

Highest levels found in the testis and bone marrow. Not found in the liver.

Gene expression databases

BgeeiENSMUSG00000041313
ExpressionAtlasiQ09143 baseline and differential
GenevisibleiQ09143 MM

Interactioni

Protein-protein interaction databases

IntActiQ09143, 1 interactor
STRINGi10090.ENSMUSP00000046714

Structurei

3D structure databases

ProteinModelPortaliQ09143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119151
HOGENOMiHOG000250623
HOVERGENiHBG000280
InParanoidiQ09143
KOiK13863
OMAiTAYEMAN
OrthoDBiEOG091G05NM
PhylomeDBiQ09143
TreeFamiTF315212

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR004755 Cat_AA_permease
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00906 2A0303, 1 hit

Sequencei

Sequence statusi: Complete.

Q09143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCKNLLGLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY
110 120 130 140 150
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ
160 170 180 190 200
HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV
210 220 230 240 250
LCFIVVSGFV KGSIKNWQLT EKNFSCNNND TNVKYGEGGF MPFGFSGVLS
260 270 280 290 300
GAATCFYAFV GFDCIATTGE EVKNPQKAIP VGIVASLLIC FIAYFGVSAA
310 320 330 340 350
LTLMMPYFCL DIDSPLPGAF KHQGWEEAKY AVAIGSLCAL STSLLGSMFP
360 370 380 390 400
MPRVIYAMAE DGLLFKFLAK INNRTKTPVI ATVTSGAIAA VMAFLFELKD
410 420 430 440 450
LVDLMSIGTL LAYSLVAACV LVLRYQPEQP NLVYQMARTT EELDRVDQNE
460 470 480 490 500
LVSASESQTG FLPVAEKFSL KSILSPKNVE PSKFSGLIVN ISAGLLAALI
510 520 530 540 550
ITVCIVAVLG REALAEGTLW AVFVMTGSVL LCMLVTGIIW RQPESKTKLS
560 570 580 590 600
FKVPFVPVLP VLSIFVNIYL MMQLDQGTWV RFAVWMLIGF TIYFGYGIWH
610 620
SEEASLAAGQ AKTPDSNLDQ CK
Length:622
Mass (Da):67,092
Last modified:October 1, 1996 - v1
Checksum:i157EE960CE737B6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26687 mRNA Translation: AAA37574.1
CCDSiCCDS19882.1
PIRiA32742
RefSeqiNP_001288353.1, NM_001301424.1
NP_031539.3, NM_007513.4
XP_006504859.1, XM_006504796.1
UniGeneiMm.275489

Genome annotation databases

EnsembliENSMUST00000048116; ENSMUSP00000046714; ENSMUSG00000041313
GeneIDi11987
KEGGimmu:11987
UCSCiuc009aos.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCTR1_MOUSE
AccessioniPrimary (citable) accession number: Q09143
Secondary accession number(s): P30824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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