Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High affinity cationic amino acid transporter 1

Gene

Slc7a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.1 Publication

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: MGI

GO - Biological processi

  1. arginine transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_230460. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.3.1. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-1
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor
Ecotropic retrovirus receptor
Short name:
ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene namesi
Name:Slc7a1
Synonyms:Atrc1, Rec-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:88117. Slc7a1.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei36 – 5722HelicalSequence AnalysisAdd
BLAST
Topological domaini58 – 614ExtracellularSequence Analysis
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 10220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 16239ExtracellularSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Topological domaini184 – 1918CytoplasmicSequence Analysis
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST
Topological domaini213 – 23927ExtracellularSequence AnalysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence AnalysisAdd
BLAST
Topological domaini261 – 28020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei281 – 30020HelicalSequence AnalysisAdd
BLAST
Topological domaini301 – 33030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST
Topological domaini352 – 37726CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Topological domaini399 – 4013ExtracellularSequence Analysis
Transmembranei402 – 42221HelicalSequence AnalysisAdd
BLAST
Topological domaini423 – 48563CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei486 – 50621HelicalSequence AnalysisAdd
BLAST
Topological domaini507 – 51913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei520 – 54425HelicalSequence AnalysisAdd
BLAST
Topological domaini545 – 5528CytoplasmicSequence Analysis
Transmembranei553 – 57321HelicalSequence AnalysisAdd
BLAST
Topological domaini574 – 5774ExtracellularSequence Analysis
Transmembranei578 – 59821HelicalSequence AnalysisAdd
BLAST
Topological domaini599 – 62224CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: MGI
  2. membrane Source: MGI
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622High affinity cationic amino acid transporter 1PRO_0000054262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ09143.
PaxDbiQ09143.
PRIDEiQ09143.

PTM databases

PhosphoSiteiQ09143.

Expressioni

Tissue specificityi

Highest levels found in the testis and bone marrow. Not found in the liver.

Gene expression databases

BgeeiQ09143.
ExpressionAtlasiQ09143. baseline and differential.
GenevestigatoriQ09143.

Interactioni

Protein-protein interaction databases

IntActiQ09143. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ09143.
SMRiQ09143. Positions 43-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ09143.
KOiK13863.
OMAiVKNWQLT.
OrthoDBiEOG72C501.
PhylomeDBiQ09143.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCKNLLGLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY
110 120 130 140 150
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ
160 170 180 190 200
HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV
210 220 230 240 250
LCFIVVSGFV KGSIKNWQLT EKNFSCNNND TNVKYGEGGF MPFGFSGVLS
260 270 280 290 300
GAATCFYAFV GFDCIATTGE EVKNPQKAIP VGIVASLLIC FIAYFGVSAA
310 320 330 340 350
LTLMMPYFCL DIDSPLPGAF KHQGWEEAKY AVAIGSLCAL STSLLGSMFP
360 370 380 390 400
MPRVIYAMAE DGLLFKFLAK INNRTKTPVI ATVTSGAIAA VMAFLFELKD
410 420 430 440 450
LVDLMSIGTL LAYSLVAACV LVLRYQPEQP NLVYQMARTT EELDRVDQNE
460 470 480 490 500
LVSASESQTG FLPVAEKFSL KSILSPKNVE PSKFSGLIVN ISAGLLAALI
510 520 530 540 550
ITVCIVAVLG REALAEGTLW AVFVMTGSVL LCMLVTGIIW RQPESKTKLS
560 570 580 590 600
FKVPFVPVLP VLSIFVNIYL MMQLDQGTWV RFAVWMLIGF TIYFGYGIWH
610 620
SEEASLAAGQ AKTPDSNLDQ CK
Length:622
Mass (Da):67,092
Last modified:October 1, 1996 - v1
Checksum:i157EE960CE737B6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26687 mRNA. Translation: AAA37574.1.
CCDSiCCDS19882.1.
PIRiA32742.
RefSeqiNP_001288353.1. NM_001301424.1.
NP_031539.3. NM_007513.4.
XP_006504859.1. XM_006504796.1.
XP_006504861.1. XM_006504798.1.
UniGeneiMm.275489.

Genome annotation databases

EnsembliENSMUST00000048116; ENSMUSP00000046714; ENSMUSG00000041313.
GeneIDi11987.
KEGGimmu:11987.
UCSCiuc009aos.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26687 mRNA. Translation: AAA37574.1.
CCDSiCCDS19882.1.
PIRiA32742.
RefSeqiNP_001288353.1. NM_001301424.1.
NP_031539.3. NM_007513.4.
XP_006504859.1. XM_006504796.1.
XP_006504861.1. XM_006504798.1.
UniGeneiMm.275489.

3D structure databases

ProteinModelPortaliQ09143.
SMRiQ09143. Positions 43-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ09143. 1 interaction.

Protein family/group databases

TCDBi2.A.3.3.1. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteiQ09143.

Proteomic databases

MaxQBiQ09143.
PaxDbiQ09143.
PRIDEiQ09143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048116; ENSMUSP00000046714; ENSMUSG00000041313.
GeneIDi11987.
KEGGimmu:11987.
UCSCiuc009aos.2. mouse.

Organism-specific databases

CTDi6541.
MGIiMGI:88117. Slc7a1.

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ09143.
KOiK13863.
OMAiVKNWQLT.
OrthoDBiEOG72C501.
PhylomeDBiQ09143.
TreeFamiTF315212.

Enzyme and pathway databases

ReactomeiREACT_230460. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSlc7a1. mouse.
NextBioi280141.
PROiQ09143.
SOURCEiSearch...

Gene expression databases

BgeeiQ09143.
ExpressionAtlasiQ09143. baseline and differential.
GenevestigatoriQ09143.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection."
    Albritton L.M., Tseng L., Scadden D., Cunningham J.M.
    Cell 57:659-666(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.
  2. "Transport of cationic amino acids by the mouse ecotropic retrovirus receptor."
    Kim J.W., Closs E.I., Albritton L.M., Cunningham J.M.
    Nature 352:725-728(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCTR1_MOUSE
AccessioniPrimary (citable) accession number: Q09143
Secondary accession number(s): P30824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.