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Q09143

- CTR1_MOUSE

UniProt

Q09143 - CTR1_MOUSE

Protein

High affinity cationic amino acid transporter 1

Gene

Slc7a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.1 Publication

    GO - Molecular functioni

    1. arginine transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. arginine transport Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Amino-acid transport, Transport

    Protein family/group databases

    TCDBi2.A.3.3.1. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High affinity cationic amino acid transporter 1
    Short name:
    CAT-1
    Short name:
    CAT1
    Alternative name(s):
    Ecotropic retroviral leukemia receptor
    Ecotropic retrovirus receptor
    Short name:
    ERR
    Solute carrier family 7 member 1
    System Y+ basic amino acid transporter
    Gene namesi
    Name:Slc7a1
    Synonyms:Atrc1, Rec-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:88117. Slc7a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 622622High affinity cationic amino acid transporter 1PRO_0000054262Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ09143.
    PRIDEiQ09143.

    PTM databases

    PhosphoSiteiQ09143.

    Expressioni

    Tissue specificityi

    Highest levels found in the testis and bone marrow. Not found in the liver.

    Gene expression databases

    ArrayExpressiQ09143.
    BgeeiQ09143.
    GenevestigatoriQ09143.

    Interactioni

    Protein-protein interaction databases

    IntActiQ09143. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09143.
    SMRiQ09143. Positions 43-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 614ExtracellularSequence Analysis
    Topological domaini83 – 10220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 16239ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 1918CytoplasmicSequence Analysis
    Topological domaini213 – 23927ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini261 – 28020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini301 – 33030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini352 – 37726CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini399 – 4013ExtracellularSequence Analysis
    Topological domaini423 – 48563CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini507 – 51913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini545 – 5528CytoplasmicSequence Analysis
    Topological domaini574 – 5774ExtracellularSequence Analysis
    Topological domaini599 – 62224CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei520 – 54425HelicalSequence AnalysisAdd
    BLAST
    Transmembranei553 – 57321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei578 – 59821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOGENOMiHOG000250623.
    HOVERGENiHBG000280.
    InParanoidiQ09143.
    KOiK13863.
    OMAiAYIAMGE.
    OrthoDBiEOG72C501.
    PhylomeDBiQ09143.
    TreeFamiTF315212.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00906. 2A0303. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q09143-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCKNLLGLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV    50
    YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY 100
    SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ 150
    HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV 200
    LCFIVVSGFV KGSIKNWQLT EKNFSCNNND TNVKYGEGGF MPFGFSGVLS 250
    GAATCFYAFV GFDCIATTGE EVKNPQKAIP VGIVASLLIC FIAYFGVSAA 300
    LTLMMPYFCL DIDSPLPGAF KHQGWEEAKY AVAIGSLCAL STSLLGSMFP 350
    MPRVIYAMAE DGLLFKFLAK INNRTKTPVI ATVTSGAIAA VMAFLFELKD 400
    LVDLMSIGTL LAYSLVAACV LVLRYQPEQP NLVYQMARTT EELDRVDQNE 450
    LVSASESQTG FLPVAEKFSL KSILSPKNVE PSKFSGLIVN ISAGLLAALI 500
    ITVCIVAVLG REALAEGTLW AVFVMTGSVL LCMLVTGIIW RQPESKTKLS 550
    FKVPFVPVLP VLSIFVNIYL MMQLDQGTWV RFAVWMLIGF TIYFGYGIWH 600
    SEEASLAAGQ AKTPDSNLDQ CK 622
    Length:622
    Mass (Da):67,092
    Last modified:October 1, 1996 - v1
    Checksum:i157EE960CE737B6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26687 mRNA. Translation: AAA37574.1.
    CCDSiCCDS19882.1.
    PIRiA32742.
    RefSeqiNP_031539.3. NM_007513.4.
    XP_006504859.1. XM_006504796.1.
    XP_006504860.1. XM_006504797.1.
    XP_006504861.1. XM_006504798.1.
    UniGeneiMm.275489.

    Genome annotation databases

    EnsembliENSMUST00000048116; ENSMUSP00000046714; ENSMUSG00000041313.
    GeneIDi11987.
    KEGGimmu:11987.
    UCSCiuc009aos.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26687 mRNA. Translation: AAA37574.1 .
    CCDSi CCDS19882.1.
    PIRi A32742.
    RefSeqi NP_031539.3. NM_007513.4.
    XP_006504859.1. XM_006504796.1.
    XP_006504860.1. XM_006504797.1.
    XP_006504861.1. XM_006504798.1.
    UniGenei Mm.275489.

    3D structure databases

    ProteinModelPortali Q09143.
    SMRi Q09143. Positions 43-372.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q09143. 1 interaction.

    Protein family/group databases

    TCDBi 2.A.3.3.1. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei Q09143.

    Proteomic databases

    PaxDbi Q09143.
    PRIDEi Q09143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048116 ; ENSMUSP00000046714 ; ENSMUSG00000041313 .
    GeneIDi 11987.
    KEGGi mmu:11987.
    UCSCi uc009aos.2. mouse.

    Organism-specific databases

    CTDi 6541.
    MGIi MGI:88117. Slc7a1.

    Phylogenomic databases

    eggNOGi COG0531.
    HOGENOMi HOG000250623.
    HOVERGENi HBG000280.
    InParanoidi Q09143.
    KOi K13863.
    OMAi AYIAMGE.
    OrthoDBi EOG72C501.
    PhylomeDBi Q09143.
    TreeFami TF315212.

    Miscellaneous databases

    ChiTaRSi SLC7A1. mouse.
    NextBioi 280141.
    PROi Q09143.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q09143.
    Bgeei Q09143.
    Genevestigatori Q09143.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00906. 2A0303. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection."
      Albritton L.M., Tseng L., Scadden D., Cunningham J.M.
      Cell 57:659-666(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fibroblast.
    2. "Transport of cationic amino acids by the mouse ecotropic retrovirus receptor."
      Kim J.W., Closs E.I., Albritton L.M., Cunningham J.M.
      Nature 352:725-728(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCTR1_MOUSE
    AccessioniPrimary (citable) accession number: Q09143
    Secondary accession number(s): P30824
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3