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Q09143

- CTR1_MOUSE

UniProt

Q09143 - CTR1_MOUSE

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Protein
High affinity cationic amino acid transporter 1
Gene
Slc7a1, Atrc1, Rec-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.1 Publication

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. arginine transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.3.1. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-1
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor
Ecotropic retrovirus receptor
Short name:
ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene namesi
Name:Slc7a1
Synonyms:Atrc1, Rec-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:88117. Slc7a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei36 – 5722Helical; Reviewed prediction
Add
BLAST
Topological domaini58 – 614Extracellular Reviewed prediction
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 10220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Topological domaini124 – 16239Extracellular Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Topological domaini184 – 1918Cytoplasmic Reviewed prediction
Transmembranei192 – 21221Helical; Reviewed prediction
Add
BLAST
Topological domaini213 – 23927Extracellular Reviewed prediction
Add
BLAST
Transmembranei240 – 26021Helical; Reviewed prediction
Add
BLAST
Topological domaini261 – 28020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei281 – 30020Helical; Reviewed prediction
Add
BLAST
Topological domaini301 – 33030Extracellular Reviewed prediction
Add
BLAST
Transmembranei331 – 35121Helical; Reviewed prediction
Add
BLAST
Topological domaini352 – 37726Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei378 – 39821Helical; Reviewed prediction
Add
BLAST
Topological domaini399 – 4013Extracellular Reviewed prediction
Transmembranei402 – 42221Helical; Reviewed prediction
Add
BLAST
Topological domaini423 – 48563Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei486 – 50621Helical; Reviewed prediction
Add
BLAST
Topological domaini507 – 51913Extracellular Reviewed prediction
Add
BLAST
Transmembranei520 – 54425Helical; Reviewed prediction
Add
BLAST
Topological domaini545 – 5528Cytoplasmic Reviewed prediction
Transmembranei553 – 57321Helical; Reviewed prediction
Add
BLAST
Topological domaini574 – 5774Extracellular Reviewed prediction
Transmembranei578 – 59821Helical; Reviewed prediction
Add
BLAST
Topological domaini599 – 62224Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622High affinity cationic amino acid transporter 1
PRO_0000054262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi223 – 2231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi229 – 2291N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ09143.
PRIDEiQ09143.

PTM databases

PhosphoSiteiQ09143.

Expressioni

Tissue specificityi

Highest levels found in the testis and bone marrow. Not found in the liver.

Gene expression databases

ArrayExpressiQ09143.
BgeeiQ09143.
GenevestigatoriQ09143.

Interactioni

Protein-protein interaction databases

IntActiQ09143. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ09143.
SMRiQ09143. Positions 43-372.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ09143.
KOiK13863.
OMAiAYIAMGE.
OrthoDBiEOG72C501.
PhylomeDBiQ09143.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09143-1 [UniParc]FASTAAdd to Basket

« Hide

MGCKNLLGLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV    50
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY 100
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ 150
HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV 200
LCFIVVSGFV KGSIKNWQLT EKNFSCNNND TNVKYGEGGF MPFGFSGVLS 250
GAATCFYAFV GFDCIATTGE EVKNPQKAIP VGIVASLLIC FIAYFGVSAA 300
LTLMMPYFCL DIDSPLPGAF KHQGWEEAKY AVAIGSLCAL STSLLGSMFP 350
MPRVIYAMAE DGLLFKFLAK INNRTKTPVI ATVTSGAIAA VMAFLFELKD 400
LVDLMSIGTL LAYSLVAACV LVLRYQPEQP NLVYQMARTT EELDRVDQNE 450
LVSASESQTG FLPVAEKFSL KSILSPKNVE PSKFSGLIVN ISAGLLAALI 500
ITVCIVAVLG REALAEGTLW AVFVMTGSVL LCMLVTGIIW RQPESKTKLS 550
FKVPFVPVLP VLSIFVNIYL MMQLDQGTWV RFAVWMLIGF TIYFGYGIWH 600
SEEASLAAGQ AKTPDSNLDQ CK 622
Length:622
Mass (Da):67,092
Last modified:October 1, 1996 - v1
Checksum:i157EE960CE737B6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26687 mRNA. Translation: AAA37574.1.
CCDSiCCDS19882.1.
PIRiA32742.
RefSeqiNP_031539.3. NM_007513.4.
XP_006504859.1. XM_006504796.1.
XP_006504860.1. XM_006504797.1.
XP_006504861.1. XM_006504798.1.
UniGeneiMm.275489.

Genome annotation databases

EnsembliENSMUST00000048116; ENSMUSP00000046714; ENSMUSG00000041313.
GeneIDi11987.
KEGGimmu:11987.
UCSCiuc009aos.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26687 mRNA. Translation: AAA37574.1 .
CCDSi CCDS19882.1.
PIRi A32742.
RefSeqi NP_031539.3. NM_007513.4.
XP_006504859.1. XM_006504796.1.
XP_006504860.1. XM_006504797.1.
XP_006504861.1. XM_006504798.1.
UniGenei Mm.275489.

3D structure databases

ProteinModelPortali Q09143.
SMRi Q09143. Positions 43-372.
ModBasei Search...

Protein-protein interaction databases

IntActi Q09143. 1 interaction.

Protein family/group databases

TCDBi 2.A.3.3.1. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSitei Q09143.

Proteomic databases

PaxDbi Q09143.
PRIDEi Q09143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048116 ; ENSMUSP00000046714 ; ENSMUSG00000041313 .
GeneIDi 11987.
KEGGi mmu:11987.
UCSCi uc009aos.2. mouse.

Organism-specific databases

CTDi 6541.
MGIi MGI:88117. Slc7a1.

Phylogenomic databases

eggNOGi COG0531.
HOGENOMi HOG000250623.
HOVERGENi HBG000280.
InParanoidi Q09143.
KOi K13863.
OMAi AYIAMGE.
OrthoDBi EOG72C501.
PhylomeDBi Q09143.
TreeFami TF315212.

Miscellaneous databases

ChiTaRSi SLC7A1. mouse.
NextBioi 280141.
PROi Q09143.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q09143.
Bgeei Q09143.
Genevestigatori Q09143.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
TIGRFAMsi TIGR00906. 2A0303. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection."
    Albritton L.M., Tseng L., Scadden D., Cunningham J.M.
    Cell 57:659-666(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.
  2. "Transport of cationic amino acids by the mouse ecotropic retrovirus receptor."
    Kim J.W., Closs E.I., Albritton L.M., Cunningham J.M.
    Nature 352:725-728(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCTR1_MOUSE
AccessioniPrimary (citable) accession number: Q09143
Secondary accession number(s): P30824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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