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Q09143 (CTR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
High affinity cationic amino acid transporter 1
Short name=CAT-1
Short name=CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor
Ecotropic retrovirus receptor
Short name=ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene names
Name:Slc7a1
Synonyms:Atrc1, Rec-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highest levels found in the testis and bone marrow. Not found in the liver.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred by curator PubMed 8385111. Source: MGI

   Molecular_functionarginine transmembrane transporter activity

Inferred from direct assay PubMed 8195186PubMed 8385111. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 622622High affinity cationic amino acid transporter 1
PRO_0000054262

Regions

Topological domain1 – 3535Cytoplasmic Potential
Transmembrane36 – 5722Helical; Potential
Topological domain58 – 614Extracellular Potential
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 10220Cytoplasmic Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 16239Extracellular Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 1918Cytoplasmic Potential
Transmembrane192 – 21221Helical; Potential
Topological domain213 – 23927Extracellular Potential
Transmembrane240 – 26021Helical; Potential
Topological domain261 – 28020Cytoplasmic Potential
Transmembrane281 – 30020Helical; Potential
Topological domain301 – 33030Extracellular Potential
Transmembrane331 – 35121Helical; Potential
Topological domain352 – 37726Cytoplasmic Potential
Transmembrane378 – 39821Helical; Potential
Topological domain399 – 4013Extracellular Potential
Transmembrane402 – 42221Helical; Potential
Topological domain423 – 48563Cytoplasmic Potential
Transmembrane486 – 50621Helical; Potential
Topological domain507 – 51913Extracellular Potential
Transmembrane520 – 54425Helical; Potential
Topological domain545 – 5528Cytoplasmic Potential
Transmembrane553 – 57321Helical; Potential
Topological domain574 – 5774Extracellular Potential
Transmembrane578 – 59821Helical; Potential
Topological domain599 – 62224Cytoplasmic Potential

Amino acid modifications

Glycosylation2231N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q09143 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 157EE960CE737B6E

FASTA62267,092
        10         20         30         40         50         60 
MGCKNLLGLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV YVLAGAVARE 

        70         80         90        100        110        120 
NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS 

       130        140        150        160        170        180 
YIIGTSSVAR AWSATFDELI GKPIGEFSRQ HMALNAPGVL AQTPDIFAVI IIIILTGLLT 

       190        200        210        220        230        240 
LGVKESAMVN KIFTCINVLV LCFIVVSGFV KGSIKNWQLT EKNFSCNNND TNVKYGEGGF 

       250        260        270        280        290        300 
MPFGFSGVLS GAATCFYAFV GFDCIATTGE EVKNPQKAIP VGIVASLLIC FIAYFGVSAA 

       310        320        330        340        350        360 
LTLMMPYFCL DIDSPLPGAF KHQGWEEAKY AVAIGSLCAL STSLLGSMFP MPRVIYAMAE 

       370        380        390        400        410        420 
DGLLFKFLAK INNRTKTPVI ATVTSGAIAA VMAFLFELKD LVDLMSIGTL LAYSLVAACV 

       430        440        450        460        470        480 
LVLRYQPEQP NLVYQMARTT EELDRVDQNE LVSASESQTG FLPVAEKFSL KSILSPKNVE 

       490        500        510        520        530        540 
PSKFSGLIVN ISAGLLAALI ITVCIVAVLG REALAEGTLW AVFVMTGSVL LCMLVTGIIW 

       550        560        570        580        590        600 
RQPESKTKLS FKVPFVPVLP VLSIFVNIYL MMQLDQGTWV RFAVWMLIGF TIYFGYGIWH 

       610        620 
SEEASLAAGQ AKTPDSNLDQ CK

« Hide

References

[1]"A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection."
Albritton L.M., Tseng L., Scadden D., Cunningham J.M.
Cell 57:659-666(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fibroblast.
[2]"Transport of cationic amino acids by the mouse ecotropic retrovirus receptor."
Kim J.W., Closs E.I., Albritton L.M., Cunningham J.M.
Nature 352:725-728(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M26687 mRNA. Translation: AAA37574.1.
IPIIPI00121634.
PIRA32742.
RefSeqNP_031539.3. NM_007513.4.
UniGeneMm.275489.

3D structure databases

ProteinModelPortalQ09143.
SMRQ09143. Positions 43-391.
ModBaseSearch...

Protein-protein interaction databases

IntActQ09143. 1 interaction.

Protein family/group databases

TCDB2.A.3.3.1. amino acid-polyamine-organocation (APC) family.

PTM databases

PhosphoSiteQ09143.

Proteomic databases

PaxDbQ09143.
PRIDEQ09143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048116; ENSMUSP00000046714; ENSMUSG00000041313.
GeneID11987.
KEGGmmu:11987.
UCSCuc009aos.2. mouse.

Organism-specific databases

CTD6541.
MGIMGI:88117. Slc7a1.

Phylogenomic databases

eggNOGCOG0531.
HOGENOMHOG000250623.
HOVERGENHBG000280.
InParanoidQ09143.
KOK13863.
OMAVKNWQLT.
OrthoDBEOG40VVP6.

Gene expression databases

ArrayExpressQ09143.
BgeeQ09143.
GenevestigatorQ09143.
GermOnlineENSMUSG00000041313. Mus musculus.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR015606. Cat-AATrans.
IPR004755. Cat_AA_permease.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PTHR11785:SF53. PTHR11785:SF53. 1 hit.
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00906. 2A0303. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC7A1. mouse.
NextBio280141.
SOURCESearch...

Entry information

Entry nameCTR1_MOUSE
AccessionPrimary (citable) accession number: Q09143
Secondary accession number(s): P30824
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 29, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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