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Q09141

- CCL8_BOVIN

UniProt

Q09141 - CCL8_BOVIN

Protein

C-C motif chemokine 8

Gene

CCL8

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts monocytes. This protein can bind heparin.

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. phospholipase activator activity Source: Ensembl
    3. protein kinase activity Source: Ensembl

    GO - Biological processi

    1. calcium ion transport Source: Ensembl
    2. cell-cell signaling Source: Ensembl
    3. cell chemotaxis Source: GOC
    4. cellular calcium ion homeostasis Source: Ensembl
    5. exocytosis Source: Ensembl
    6. immune response Source: InterPro
    7. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 8
    Alternative name(s):
    Monocyte chemoattractant protein 2
    Monocyte chemotactic protein 2
    Short name:
    MCP-2
    Small-inducible cytokine A8
    Gene namesi
    Name:CCL8
    Synonyms:MCP2, SCYA8
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 8PRO_0000005186Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiQ09141.

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000044836.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09141.
    SMRiQ09141. Positions 24-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG75507.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ09141.
    KOiK16596.
    OMAiQKLESYT.
    OrthoDBiEOG7C5MC2.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q09141-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAGILCL LLVAATFGTQ VLAQPDSVST PITCCFSVIN GKIPFKKLDS   50
    YTRITNSQCP QEAVIFKTKA DRDVCADPKQ KWVQTSIRLL DQKSRTPKP 99
    Length:99
    Mass (Da):10,900
    Last modified:November 1, 1995 - v1
    Checksum:i01974CDB3FF9119B
    GO

    Sequence cautioni

    The sequence AAK94451.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67954 mRNA. Translation: AAD14005.1.
    S67956 Genomic DNA. Translation: AAB29750.1.
    AF399641 mRNA. Translation: AAK94451.1. Different initiation.
    BC142112 mRNA. Translation: AAI42113.1.
    RefSeqiNP_776432.1. NM_174007.1.
    XP_005192928.1. XM_005192871.1.
    UniGeneiBt.154.

    Genome annotation databases

    EnsembliENSBTAT00000018757; ENSBTAP00000018757; ENSBTAG00000014113.
    GeneIDi281044.
    788169.
    KEGGibta:281044.
    bta:788169.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67954 mRNA. Translation: AAD14005.1 .
    S67956 Genomic DNA. Translation: AAB29750.1 .
    AF399641 mRNA. Translation: AAK94451.1 . Different initiation.
    BC142112 mRNA. Translation: AAI42113.1 .
    RefSeqi NP_776432.1. NM_174007.1.
    XP_005192928.1. XM_005192871.1.
    UniGenei Bt.154.

    3D structure databases

    ProteinModelPortali Q09141.
    SMRi Q09141. Positions 24-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000044836.

    Proteomic databases

    PRIDEi Q09141.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000018757 ; ENSBTAP00000018757 ; ENSBTAG00000014113 .
    GeneIDi 281044.
    788169.
    KEGGi bta:281044.
    bta:788169.

    Organism-specific databases

    CTDi 6355.

    Phylogenomic databases

    eggNOGi NOG75507.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q09141.
    KOi K16596.
    OMAi QKLESYT.
    OrthoDBi EOG7C5MC2.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 20805130.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the gene for bovine monocyte chemoattractant protein-2."
      Wempe F., Hanes J., Scheit K.H.
      DNA Cell Biol. 13:1-8(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Role of chemokines in respiratory syncytial virus infection."
      Werling D.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCCL8_BOVIN
    AccessioniPrimary (citable) accession number: Q09141
    Secondary accession number(s): A5PJH3, Q95MD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3