Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q09141

- CCL8_BOVIN

UniProt

Q09141 - CCL8_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

C-C motif chemokine 8

Gene

CCL8

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes. This protein can bind heparin.

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. phospholipase activator activity Source: Ensembl
  3. protein kinase activity Source: Ensembl

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. cell-cell signaling Source: Ensembl
  3. cell chemotaxis Source: GOC
  4. cellular calcium ion homeostasis Source: Ensembl
  5. exocytosis Source: Ensembl
  6. immune response Source: InterPro
  7. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 8
Alternative name(s):
Monocyte chemoattractant protein 2
Monocyte chemotactic protein 2
Short name:
MCP-2
Small-inducible cytokine A8
Gene namesi
Name:CCL8
Synonyms:MCP2, SCYA8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 8PRO_0000005186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiQ09141.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044836.

Structurei

3D structure databases

ProteinModelPortaliQ09141.
SMRiQ09141. Positions 24-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG75507.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ09141.
KOiK16596.
OMAiQKLESYT.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09141-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSAGILCL LLVAATFGTQ VLAQPDSVST PITCCFSVIN GKIPFKKLDS
60 70 80 90
YTRITNSQCP QEAVIFKTKA DRDVCADPKQ KWVQTSIRLL DQKSRTPKP
Length:99
Mass (Da):10,900
Last modified:November 1, 1995 - v1
Checksum:i01974CDB3FF9119B
GO

Sequence cautioni

The sequence AAK94451.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67954 mRNA. Translation: AAD14005.1.
S67956 Genomic DNA. Translation: AAB29750.1.
AF399641 mRNA. Translation: AAK94451.1. Different initiation.
BC142112 mRNA. Translation: AAI42113.1.
RefSeqiNP_776432.1. NM_174007.1.
XP_005192928.1. XM_005192871.1.
UniGeneiBt.154.

Genome annotation databases

EnsembliENSBTAT00000018757; ENSBTAP00000018757; ENSBTAG00000014113.
GeneIDi281044.
788169.
KEGGibta:281044.
bta:788169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67954 mRNA. Translation: AAD14005.1 .
S67956 Genomic DNA. Translation: AAB29750.1 .
AF399641 mRNA. Translation: AAK94451.1 . Different initiation.
BC142112 mRNA. Translation: AAI42113.1 .
RefSeqi NP_776432.1. NM_174007.1.
XP_005192928.1. XM_005192871.1.
UniGenei Bt.154.

3D structure databases

ProteinModelPortali Q09141.
SMRi Q09141. Positions 24-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000044836.

Proteomic databases

PRIDEi Q09141.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000018757 ; ENSBTAP00000018757 ; ENSBTAG00000014113 .
GeneIDi 281044.
788169.
KEGGi bta:281044.
bta:788169.

Organism-specific databases

CTDi 6355.

Phylogenomic databases

eggNOGi NOG75507.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi Q09141.
KOi K16596.
OMAi QKLESYT.
OrthoDBi EOG7C5MC2.
TreeFami TF334888.

Miscellaneous databases

NextBioi 20805130.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the gene for bovine monocyte chemoattractant protein-2."
    Wempe F., Hanes J., Scheit K.H.
    DNA Cell Biol. 13:1-8(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Role of chemokines in respiratory syncytial virus infection."
    Werling D.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiCCL8_BOVIN
AccessioniPrimary (citable) accession number: Q09141
Secondary accession number(s): A5PJH3, Q95MD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3