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Q09141 (CCL8_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 8
Alternative name(s):
Monocyte chemoattractant protein 2
Monocyte chemotactic protein 2
Short name=MCP-2
Small-inducible cytokine A8
Gene names
Name:CCL8
Synonyms:MCP2, SCYA8
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic factor that attracts monocytes. This protein can bind heparin.

Subunit structure

Monomer or homodimer; in equilibrium By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence caution

The sequence AAK94451.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 9976C-C motif chemokine 8
PRO_0000005186

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid By similarity
Disulfide bond34 ↔ 59 By similarity
Disulfide bond35 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09141 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 01974CDB3FF9119B

FASTA9910,900
        10         20         30         40         50         60 
MKVSAGILCL LLVAATFGTQ VLAQPDSVST PITCCFSVIN GKIPFKKLDS YTRITNSQCP 

        70         80         90 
QEAVIFKTKA DRDVCADPKQ KWVQTSIRLL DQKSRTPKP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the gene for bovine monocyte chemoattractant protein-2."
Wempe F., Hanes J., Scheit K.H.
DNA Cell Biol. 13:1-8(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Role of chemokines in respiratory syncytial virus infection."
Werling D.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S67954 mRNA. Translation: AAD14005.1.
S67956 Genomic DNA. Translation: AAB29750.1.
AF399641 mRNA. Translation: AAK94451.1. Different initiation.
BC142112 mRNA. Translation: AAI42113.1.
RefSeqNP_776432.1. NM_174007.1.
XP_005192928.1. XM_005192871.1.
UniGeneBt.154.

3D structure databases

ProteinModelPortalQ09141.
SMRQ09141. Positions 24-99.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000044836.

Proteomic databases

PRIDEQ09141.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000018757; ENSBTAP00000018757; ENSBTAG00000014113.
GeneID281044.
788169.
KEGGbta:281044.
bta:788169.

Organism-specific databases

CTD6355.

Phylogenomic databases

eggNOGNOG75507.
GeneTreeENSGT00730000110714.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidQ09141.
KOK16596.
OMAQKLESYT.
OrthoDBEOG7C5MC2.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805130.

Entry information

Entry nameCCL8_BOVIN
AccessionPrimary (citable) accession number: Q09141
Secondary accession number(s): A5PJH3, Q95MD5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families