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Protein

C-C motif chemokine 8

Gene

CCL8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes. This protein can bind heparin.

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. phospholipase activator activity Source: Ensembl
  3. protein kinase activity Source: Ensembl

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. cell-cell signaling Source: Ensembl
  3. cell chemotaxis Source: GOC
  4. cellular calcium ion homeostasis Source: Ensembl
  5. exocytosis Source: Ensembl
  6. immune response Source: InterPro
  7. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 8
Alternative name(s):
Monocyte chemoattractant protein 2
Monocyte chemotactic protein 2
Short name:
MCP-2
Small-inducible cytokine A8
Gene namesi
Name:CCL8
Synonyms:MCP2, SCYA8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 19

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 8PRO_0000005186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiQ09141.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044836.

Structurei

3D structure databases

ProteinModelPortaliQ09141.
SMRiQ09141. Positions 24-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG75507.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ09141.
KOiK16596.
OMAiSMKHLDQ.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAGILCL LLVAATFGTQ VLAQPDSVST PITCCFSVIN GKIPFKKLDS
60 70 80 90
YTRITNSQCP QEAVIFKTKA DRDVCADPKQ KWVQTSIRLL DQKSRTPKP
Length:99
Mass (Da):10,900
Last modified:October 31, 1995 - v1
Checksum:i01974CDB3FF9119B
GO

Sequence cautioni

The sequence AAK94451.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67954 mRNA. Translation: AAD14005.1.
S67956 Genomic DNA. Translation: AAB29750.1.
AF399641 mRNA. Translation: AAK94451.1. Different initiation.
BC142112 mRNA. Translation: AAI42113.1.
RefSeqiNP_776432.1. NM_174007.1.
XP_005192928.1. XM_005192871.2.
XP_010814096.1. XM_010815794.1.
UniGeneiBt.154.

Genome annotation databases

EnsembliENSBTAT00000018757; ENSBTAP00000018757; ENSBTAG00000014113.
GeneIDi281044.
788169.
KEGGibta:281044.
bta:788169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67954 mRNA. Translation: AAD14005.1.
S67956 Genomic DNA. Translation: AAB29750.1.
AF399641 mRNA. Translation: AAK94451.1. Different initiation.
BC142112 mRNA. Translation: AAI42113.1.
RefSeqiNP_776432.1. NM_174007.1.
XP_005192928.1. XM_005192871.2.
XP_010814096.1. XM_010815794.1.
UniGeneiBt.154.

3D structure databases

ProteinModelPortaliQ09141.
SMRiQ09141. Positions 24-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044836.

Proteomic databases

PRIDEiQ09141.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018757; ENSBTAP00000018757; ENSBTAG00000014113.
GeneIDi281044.
788169.
KEGGibta:281044.
bta:788169.

Organism-specific databases

CTDi6355.

Phylogenomic databases

eggNOGiNOG75507.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ09141.
KOiK16596.
OMAiSMKHLDQ.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Miscellaneous databases

NextBioi20805130.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the gene for bovine monocyte chemoattractant protein-2."
    Wempe F., Hanes J., Scheit K.H.
    DNA Cell Biol. 13:1-8(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Role of chemokines in respiratory syncytial virus infection."
    Werling D.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiCCL8_BOVIN
AccessioniPrimary (citable) accession number: Q09141
Secondary accession number(s): A5PJH3, Q95MD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: March 3, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.