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Protein

Fatty acid-binding protein, brain

Gene

FABP7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long chain fatty acids and their acyl-CoA esters. Binds oleic and palmitic acids but not palmitoyl CoA.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-BTA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, brain
Alternative name(s):
Brain-type fatty acid-binding protein
Short name:
B-FABP
Fatty acid-binding protein 7
Gene namesi
Name:FABP7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 132131Fatty acid-binding protein, brainPRO_0000067372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylvalineCurated

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ09139.
PeptideAtlasiQ09139.
PRIDEiQ09139.

Interactioni

Subunit structurei

Monomer.2 Publications

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017593.

Structurei

3D structure databases

ProteinModelPortaliQ09139.
SMRiQ09139. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid bindingBy similarity

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ09139.
KOiK08756.
OMAiWKLTESQ.
OrthoDBiEOG7NW6BZ.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEAFCATWK LTESQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGDRV
60 70 80 90 100
VIRTQSTFKN TEISFHLGEE FDETTADDRN CKSVVSLDGD KLVHVQKWDG
110 120 130
KETNFVREIK DGKMIMTLTF GDVVAVRHYE KA
Length:132
Mass (Da):14,956
Last modified:February 5, 2008 - v2
Checksum:i0FB37FC72C150517
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118369 mRNA. Translation: AAI18370.1.
PIRiS06479.
RefSeqiNP_001071630.1. NM_001078162.2.
UniGeneiBt.2892.

Genome annotation databases

EnsembliENSBTAT00000017593; ENSBTAP00000017593; ENSBTAG00000033803.
GeneIDi777787.
KEGGibta:777787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118369 mRNA. Translation: AAI18370.1.
PIRiS06479.
RefSeqiNP_001071630.1. NM_001078162.2.
UniGeneiBt.2892.

3D structure databases

ProteinModelPortaliQ09139.
SMRiQ09139. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017593.

Proteomic databases

PaxDbiQ09139.
PeptideAtlasiQ09139.
PRIDEiQ09139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017593; ENSBTAP00000017593; ENSBTAG00000033803.
GeneIDi777787.
KEGGibta:777787.

Organism-specific databases

CTDi2173.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ09139.
KOiK08756.
OMAiWKLTESQ.
OrthoDBiEOG7NW6BZ.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-BTA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.
  2. "Fatty-acid-binding protein from bovine brain. Amino acid sequence and some properties."
    Schoentgen F., Pignede G., Bonanno L.M., Jolles P.
    Eur. J. Biochem. 185:35-40(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-132, SUBUNIT, FUNCTION.
    Tissue: Brain.
  3. "Amino acid sequence and some ligand binding properties of fatty acid-binding protein from bovine brain."
    Schoentgen F., Bonanno L.M., Pignede G., Jolles P.
    Mol. Cell. Biochem. 98:35-39(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-132, SUBUNIT, FUNCTION.
    Tissue: Brain.

Entry informationi

Entry nameiFABP7_BOVIN
AccessioniPrimary (citable) accession number: Q09139
Secondary accession number(s): Q17QG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 5, 2008
Last modified: July 6, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.