ID   SCRK_LACLA              Reviewed;          25 AA.
AC   Q09124;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   16-JUN-2009, entry version 41.
DE   RecName: Full=Fructokinase-1;
DE            EC=2.7.1.4;
DE   AltName: Full=Fructokinase I;
DE   Flags: Fragment;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   PROTEIN SEQUENCE, AND CHARACTERIZATION.
RC   STRAIN=K1;
RX   MEDLINE=92042212; PubMed=1658003;
RA   Thompson J., Sackett D.L., Donkersloot J.A.;
RT   "Purification and properties of fructokinase I from Lactococcus
RT   lactis. Localization of scrK on the sucrose-nisin transposon Tn5306.";
RL   J. Biol. Chem. 266:22626-22633(1991).
CC   -!- CATALYTIC ACTIVITY: ATP + D-fructose = ADP + D-fructose 6-
CC       phosphate.
CC   -!- COFACTOR: Magnesium.
CC   -!- ENZYME REGULATION: Inhibition by zinc ions (Potential).
CC       Inactivated by EDTA.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 7.0-8.0;
CC   -!- SUBUNIT: Homodimer.
CC   -!- MISCELLANEOUS: Two isoforms, fructokinase I and II, have been
CC       found in this organism.
CC   -!- SIMILARITY: Belongs to the ROK (nagC/xylR) family.
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DR   PIR; A39319; A39319.
DR   BioCyc; MetaCyc:MON-13045; -.
DR   BRENDA; 2.7.1.4; 278870.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IEA:EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000600; ROK.
DR   PROSITE; PS01125; ROK; PARTIAL.
PE   1: Evidence at protein level;
KW   ATP-binding; Carbohydrate metabolism; Direct protein sequencing;
KW   Kinase; Magnesium; Metal-binding; Nucleotide-binding; Transferase;
KW   Zinc.
FT   CHAIN         1    >25       Fructokinase-1.
FT                                /FTId=PRO_0000095684.
FT   NON_TER      25     25
SQ   SEQUENCE   25 AA;  2702 MW;  9C2B771CE8D5A1E8 CRC64;
     SVYYGSIEAG GTKFVLAIAD EHFNI
//