Reviewed, UniProtKB/Swiss-Prot Q09115 (DHE3_PYRWO)

Names and origin

Protein names

Recommended name:
    Glutamate dehydrogenase
      Short name=GDH
    EC=1.4.1.3

Gene names

Name:	gdhA
Synonyms:	gdh

Organism

Pyrococcus woesei

Taxonomic identifier

2262 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	24 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H.
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›24	›24	Glutamate dehydrogenase		PRO_0000182760
Experimental info
	Non-terminal residue	24	1

Sequences

	Sequence		Length	Mass (Da)
	Q09115-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 67FD81A4C45DBBC7	FASTA	24	2,882
	10 20 VEQDPYEIVI KQLERAAQYM EISE

References

[1]

"The glutamate dehydrogenase-encoding gene of the hyperthermophilic archaeon Pyrococcus furiosus: sequence, transcription and analysis of the deduced amino acid sequence." Eggen R.I.L., Geerling A.C.M., Waldkoetter K., Antranikian G., de Vos W.M. Gene 132:143-148(1993) [PubMed: 8406037] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
HSSP	HSSP built from PDB template 1GTM based on UniProtKB P80319.
ModBase	Search...
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DHase. [Graphical view]
PROSITE	PS00074. GLFV_DEHYDROGENASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHE3_PYRWO

Accession

Primary (citable) accession number: Q09115

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 4, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)