Reviewed, UniProtKB/Swiss-Prot Q09109 (TR2M_AGRRH)

Names and origin

Protein names

Recommended name:
    Tryptophan 2-monooxygenase
    EC=1.13.12.3

Gene names

Name:

aux1

Encoded on

Plasmid pRiA4

Organism

Agrobacterium rhizogenes

Taxonomic identifier

359 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	749 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-tryptophan + O2 = (indol-3-yl)acetamide + CO2 + H2O.
Pathway	Plant hormone metabolism; auxin biosynthesis.
Sequence similarities	Belongs to the tryptophan 2-monooxygenase family.

Ontologies

Keywords
Biological process	Auxin biosynthesis
Molecular function	Monooxygenase Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	auxin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	tryptophan 2-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 749	749	Tryptophan 2-monooxygenase		PRO_0000065585

Sequences

	Sequence		Length	Mass (Da)
	Q09109-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 8B7793970206F97B	FASTA	749	83,178
	10 20 30 40 50 60 MAGSSFTLPS TGSAPLDMML IDDSDLLQLG LQQVFSKRYT ETPQSRYKLT RRASPDVSSG 70 80 90 100 110 120 EGNVHALAFI YVNAETLQMI KNARSLTEAN GVKDLVAIDV PPFRNDFSRA LLLQVINLLG 130 140 150 160 170 180 NNRNADDDLS HFIAVALPNS ARSKILTTAP FEGSLSENFR GFPITREGNV ACEVLAYGNN 190 200 210 220 230 240 LMPKACSDSF PTVDLLYDYG KFFESCAADG RIGYFPEGVT KPKVAIIGAG FSGLVAASEL 250 260 270 280 290 300 LHAGVDDVTV YEASDRLGGK LWSHGFKSAP NVIAEMGAMR FPRSESCLFF YLKKHGLDSV 310 320 330 340 350 360 GLFPNPGSVD TALFYRGRQY IWKAGEEPPE LFRRVHHGWR AFLQDGYLHD GVMLASPLAI 370 380 390 400 410 420 VDALNLGHLQ QAHGFWQSWL TYFERESFSS GIEKMFLGNH PPGGEQWNSL DDLDLFKALG 430 440 450 460 470 480 IGSGGFGPVF ESGFIEILRL VVNGYEDNVR LSYEGISELP HRIASQVING RSIRERTIHV 490 500 510 520 530 540 QVEQIDREED KINIKIKGGK VEVYDRVLVT SGFANIEMRH LLTSSNAFFH ADVSHAIGNS 550 560 570 580 590 600 HMTGASKLFL LTNEKFWLQH HLPSCILTTG VAKAVYCLDY DPRDPSGKGL VLISYTWEDD 610 620 630 640 650 660 SHKLLAVPDK RERFASLQRD IGRAFPDFAK HLTPADGNYD DNIVQHDWLT DPHAGGAFKL 670 680 690 700 710 720 NRRGNDVYSE RLFFQPFDVM HPADDKGLYL AGCSCSFTGG WVHGAIQTAC NATCAIIYGS 730 740 GHLQELIHWR HLKEGNPLAH AWKRYRYQA

References

[1]	"The TR-DNA region carrying the auxin synthesis genes of the Agrobacterium rhizogenes agropine-type plasmid pRiA4: nucleotide sequence analysis and introduction into tobacco plants." Camilleri C., Jouanin L. Mol. Plant Microbe Interact. 4:155-162(1991) [PubMed: 1932811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A4.
[2]	"Multiple regions of a divergent promoter control the expression of the Agrobacterium rhizogenes aux1 and aux2 plant oncogenes." Gaudin V., Camilleri C., Jouanin L. Mol. Gen. Genet. 239:225-234(1993) [PubMed: 8510649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12. Strain: A4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M61151 Genomic DNA. Translation: AAA22080.1. S62276 Genomic DNA. Translation: AAP13934.1.
PIR	I39708.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.13.12.3. 2198.
Family and domain databases
InterPro	IPR000759. Adrndx_reductase. IPR002937. Amino_oxidase. IPR006064. Glycosidase. IPR012142. Trp_2-mOase. [Graphical view]
Pfam	PF01593. Amino_oxidase. 1 hit. PF02027. RolB_RolC. 1 hit. [Graphical view]
PIRSF	PIRSF000319. Trp_2-mono_O2ase. 1 hit.
PRINTS	PR00419. ADXRDTASE.
ProtoNet	Search...

Entry information

Entry name

TR2M_AGRRH

Accession

Primary (citable) accession number: Q09109
Secondary accession number(s): Q841R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)