Q09103 (DGK2_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 111.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Eye-specific diacylglycerol kinase Short name=DAG kinase 2 Short name=DGK 2 Short name=Diglyceride kinase 2 EC=2.7.1.107 Alternative name(s): Retinal degeneration A protein | ||||||
| Gene names |
| ||||||
| Organism | Drosophila melanogaster (Fruit fly) | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 1457 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Required for the maintenance of phospholipid turnover within the photoreceptor. Ref.1 |
| Catalytic activity | ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Subcellular location | |
| Tissue specificity | Expressed specifically in adult eye. Ref.1 |
| Disruption phenotype | Flies exhibit photoreceptor cells that degenerate within a week after eclosion. Ref.1 |
| Sequence similarities | Belongs to the eukaryotic diacylglycerol kinase family. Contains 4 ANK repeats. Contains 1 DAGKc domain. Contains 2 phorbol-ester/DAG-type zinc fingers. |
| Sequence caution | The sequence AAQ22428.1 differs from that shown. Reason: Intron retention. |
Ontologies
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform A (identifier: Q09103-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform B (identifier: Q09103-3) The sequence of this isoform differs from the canonical sequence as follows: 1-116: MQQQQQPSID...KQQSSSSASA → MPERSISQRD...EDIEMLDYDT 117-564: Missing. 1315-1315: S → SNKDRLFSFNEDVFGCGFS 1445-1457: KQGTQPVDGWLDD → QERFMHLEKQTRI | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform C (identifier: Q09103-2) The sequence of this isoform differs from the canonical sequence as follows: 1-132: MQQQQQPSID...AGFLQVPLAA → MERLLHAVRE...SLGAWRRKRR 133-565: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1457 | 1457 | Eye-specific diacylglycerol kinase | PRO_0000218474 | |||||
Regions | |||||||||
| Domain | 808 – 944 | 137 | DAGKc | ||||||
| Repeat | 1320 – 1349 | 30 | ANK 1 | ||||||
| Repeat | 1353 – 1382 | 30 | ANK 2 | ||||||
| Repeat | 1389 – 1418 | 30 | ANK 3 | ||||||
| Repeat | 1422 – 1451 | 30 | ANK 4 | ||||||
| Zinc finger | 591 – 641 | 51 | Phorbol-ester/DAG-type 1 | ||||||
| Zinc finger | 661 – 724 | 64 | Phorbol-ester/DAG-type 2 | ||||||
| Compositional bias | 2 – 6 | 5 | Poly-Gln | ||||||
| Compositional bias | 24 – 39 | 16 | Thr-rich | ||||||
| Compositional bias | 110 – 115 | 6 | Poly-Ser | ||||||
| Compositional bias | 227 – 231 | 5 | Poly-Glu | ||||||
| Compositional bias | 763 – 778 | 16 | Gly-rich | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 132 | 132 | MQQQQ…VPLAA → MERLLHAVREEFQTEDEYET EVDDEGNVLHRSSISSCSSS SSSSNTSSSSDGSNSTASQP LSPSLPQPRRRLQRSDSFGS VGGGVAGGVAGSGATGAGGV RRFRRSSIGMQRKSAFRQRK LDSLGAWRRKRR in isoform C. | VSP_030265 | |||||
| Alternative sequence | 1 – 116 | 116 | MQQQQ…SSASA → MPERSISQRDLDEIEIESDE EEEELEQGVGLSTRSRRNRR GASDSPAASRARNATNGIQN RGRERERERERERSRERFGG TNAADEARFYDDEEQRMEDD GEEDSDEDIEMLDYDT in isoform B. | VSP_030264 | |||||
| Alternative sequence | 117 – 564 | 448 | Missing in isoform B. | VSP_030266 | |||||
| Alternative sequence | 133 – 565 | 433 | Missing in isoform C. | VSP_030267 | |||||
| Alternative sequence | 1315 | 1 | S → SNKDRLFSFNEDVFGCGFS in isoform B. | VSP_028732 | |||||
| Alternative sequence | 1445 – 1457 | 13 | KQGTQ…GWLDD → QERFMHLEKQTRI in isoform B. | VSP_028733 | |||||
Experimental info | |||||||||
| Sequence conflict | 32 | 1 | A → V in BAA04135. Ref.1 | ||||||
| Sequence conflict | 208 | 1 | S → T in BAA04135. Ref.1 | ||||||
| Sequence conflict | 438 | 1 | N → K in BAA04135. Ref.1 | ||||||
| Sequence conflict | 565 | 1 | R → RR in BAA04135. Ref.1 | ||||||
| Sequence conflict | 667 | 1 | K → N in BAA04135. Ref.1 | ||||||
| Sequence conflict | 679 – 684 | 6 | Missing in BAA04135. Ref.1 | ||||||
| Sequence conflict | 778 | 1 | G → GGG in BAA04135. Ref.1 | ||||||
| Sequence conflict | 924 | 1 | L → M in AAQ22428. Ref.5 | ||||||
| Sequence conflict | 983 | 1 | E → G in AAQ22428. Ref.5 | ||||||
| Sequence conflict | 1128 | 1 | I → N in AAQ22428. Ref.5 | ||||||
Sequences
| ||||||||||||||||||||||||||||||
References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D17315 mRNA. Translation: BAA04135.1. AE014298 Genomic DNA. Translation: AAF46430.2. AE014298 Genomic DNA. Translation: ABW09364.1. AE014298 Genomic DNA. Translation: ABW09365.1. AY075349 mRNA. Translation: AAL68208.1. BT009959 mRNA. Translation: AAQ22428.1. Sequence problems. |
| PIR | T13709. |
| RefSeq | NP_001096916.1. NM_001103446.2. NP_001096917.1. NM_001103447.2. NP_511092.2. NM_078537.3. |
3D structure databases | |
| ProteinModelPortal | Q09103. |
| SMR | Q09103. Positions 590-642, 1324-1445. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q09103. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0302660; FBpp0291800; FBgn0261549. |
| GeneID | 31826. |
| KEGG | dme:Dmel_CG42667. |
| NMPDR | fig|7227.3.peg.17065. |
Organism-specific databases | |
| CTD | 31826. |
| FlyBase | FBgn0261549. rdgA. |
Phylogenomic databases | |
| eggNOG | inNOG05289. |
| GeneTree | EMGT00050000007391. |
| InParanoid | Q09103. |
| OMA | ATYLESK. |
| OrthoDB | EOG4P2NH2. |
| PhylomeDB | Q09103. |
Gene expression databases | |
| Bgee | Q09103. |
| GermOnline | CG10966. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000756. Diacylglycerol_kin_accessory. IPR001206. Diacylglycerol_kinase_cat_dom. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. |
| Pfam | PF00023. Ank. 2 hits. PF00130. C1_1. 2 hits. PF00609. DAGK_acc. 1 hit. PF00781. DAGK_cat. 1 hit. [Graphical view] |
| SMART | SM00248. ANK. 4 hits. SM00109. C1. 1 hit. SM00045. DAGKa. 1 hit. SM00046. DAGKc. 1 hit. [Graphical view] |
| SUPFAM | SSF48403. ANK. 1 hit. |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50146. DAGK. 1 hit. PS00479. ZF_DAG_PE_1. False negative. PS50081. ZF_DAG_PE_2. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 775516. |
Entry information
| Entry name | DGK2_DROME | ||||||||
| Accession | Primary (citable) accession number: Q09103 Secondary accession number(s): A8JV38 Q9W3A4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with