ID   CATL1_FASHE             Reviewed;          20 AA.
AC   Q09093;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=Cathepsin L1;
DE            EC=3.4.22.15;
DE   Flags: Fragment;
OS   Fasciola hepatica (Liver fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea;
OC   Echinostomida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC   Fasciola.
OX   NCBI_TaxID=6192;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   MEDLINE=94158959; PubMed=8114809; DOI=10.1016/0166-6851(93)90171-S;
RA   Smith A.M., Dowd A.J., McGonigle S., Keegan P.S., Brennan G.,
RA   Trudgett A., Dalton J.P.;
RT   "Purification of a cathepsin L-like proteinase secreted by adult
RT   Fasciola hepatica.";
RL   Mol. Biochem. Parasitol. 62:1-8(1993).
CC   -!- FUNCTION: Thiol protease that assists the parasite in burrowing
CC       through the gut wall and liver of its mammalian host.
CC   -!- CATALYTIC ACTIVITY: Specificity close to that of papain. As
CC       compared to cathepsin B, cathepsin L exhibits higher activity
CC       toward protein substrates, but has little activity on Z-Arg-Arg-
CC       NHMec, and no peptidyl-dipeptidase activity.
CC   -!- SUBUNIT: Dimer of a heavy and a light chain linked by disulfide
CC       bonds.
CC   -!- SUBCELLULAR LOCATION: Lysosome.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   PIR; S68785; S68785.
DR   MEROPS; C01.033; -.
DR   BRENDA; 3.4.22.15; 39370.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   ProDom; PD000158; Peptidase_C1; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; PARTIAL.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; PARTIAL.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; PARTIAL.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydrolase; Lysosome;
KW   Protease; Thiol protease.
FT   CHAIN         1    >20       Cathepsin L1.
FT                                /FTId=PRO_0000050538.
FT   NON_TER      20     20
SQ   SEQUENCE   20 AA;  2174 MW;  97CDEDB33055BCAE CRC64;
     AVPDKIDPRE SGYVTGVKDQ
//