Q09093 (CATL1_FASHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Cathepsin L1 EC=3.4.22.15
Organism	Fasciola hepatica (Liver fluke)
Taxonomic identifier	6192 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Echinostomida › Echinostomata › Echinostomatoidea › Fasciolidae › Fasciola

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.
Catalytic activity	Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Subunit structure	Dimer of a heavy and a light chain linked by disulfide bonds.
Subcellular location	Lysosome.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›20	›20	Cathepsin L1		PRO_0000050538
Experimental info
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	Q09093 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 97CDEDB33055BCAE	FASTA	20	2,174
	10 20 AVPDKIDPRE SGYVTGVKDQ

References

[1]	"Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica." Smith A.M., Dowd A.J., McGonigle S., Keegan P.S., Brennan G., Trudgett A., Dalton J.P. Mol. Biochem. Parasitol. 62:1-8(1993) [PubMed: 8114809] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	S68785.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	C01.033.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS00640. THIOL_PROTEASE_ASN. Partial match. PS00139. THIOL_PROTEASE_CYS. Partial match. PS00639. THIOL_PROTEASE_HIS. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATL1_FASHE

Accession

Primary (citable) accession number: Q09093

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 16, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)