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Protein

ADP/ATP translocase 2

Gene

Slc25a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801NucleotideBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chromosome partition, Transport

Enzyme and pathway databases

ReactomeiR-RNO-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 2
Alternative name(s):
ADP,ATP carrier protein 2
Adenine nucleotide translocator 2
Short name:
ANT 2
Solute carrier family 25 member 5
Cleaved into the following chain:
Gene namesi
Name:Slc25a5
Synonyms:Ant2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi620353. Slc25a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 3935Helical; Name=1By similarityAdd
BLAST
Transmembranei75 – 10026Helical; Name=2By similarityAdd
BLAST
Transmembranei109 – 14335Helical; Name=3By similarityAdd
BLAST
Transmembranei176 – 20227Helical; Name=4By similarityAdd
BLAST
Transmembranei207 – 24135Helical; Name=5By similarityAdd
BLAST
Transmembranei273 – 29826Helical; Name=6By similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298ADP/ATP translocase 2PRO_0000423223Add
BLAST
Initiator methionineiRemoved; alternate1 Publication
Chaini2 – 298297ADP/ATP translocase 2, N-terminally processedPRO_0000090582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylthreonine; in ADP/ATP translocase 2, N-terminally processed1 Publication
Modified residuei23 – 231N6-malonyllysineBy similarity
Modified residuei43 – 431N6-succinyllysineBy similarity
Modified residuei52 – 521N6,N6-dimethyllysine; alternateBy similarity
Modified residuei52 – 521N6-methyllysine; alternateBy similarity
Modified residuei92 – 921N6-malonyllysineBy similarity
Modified residuei96 – 961N6-malonyllysineBy similarity
Modified residuei105 – 1051N6-acetyllysine; alternateBy similarity
Modified residuei105 – 1051N6-succinyllysine; alternateBy similarity
Modified residuei147 – 1471N6-acetyllysine; alternateBy similarity
Modified residuei147 – 1471N6-malonyllysine; alternateBy similarity
Modified residuei147 – 1471N6-succinyllysine; alternateBy similarity
Modified residuei155 – 1551N6-acetyllysine; alternateBy similarity
Modified residuei155 – 1551N6-succinyllysine; alternateBy similarity
Modified residuei163 – 1631N6-acetyllysineBy similarity
Modified residuei166 – 1661N6-acetyllysineBy similarity
Modified residuei268 – 2681N6-acetyllysine; alternateBy similarity
Modified residuei268 – 2681N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ09073.
PRIDEiQ09073.

PTM databases

iPTMnetiQ09073.
PhosphoSiteiQ09073.

Expressioni

Tissue specificityi

Present in kidney, brain, heart, liver and skeletal muscle.

Gene expression databases

GenevisibleiQ09073. RN.

Interactioni

Subunit structurei

Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5 (By similarity).By similarity

Protein-protein interaction databases

BioGridi247232. 1 interaction.
IntActiQ09073. 3 interactions.
MINTiMINT-4596867.
STRINGi10116.ENSRNOP00000015913.

Structurei

3D structure databases

ProteinModelPortaliQ09073.
SMRiQ09073. Positions 2-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 9893Solcar 1Add
BLAST
Repeati111 – 20191Solcar 2Add
BLAST
Repeati212 – 29786Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi235 – 2406Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiQ09073.
KOiK05863.
OMAiCFARTYK.
OrthoDBiEOG7T1RBR.
PhylomeDBiQ09073.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKRTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKAGA
160 170 180 190 200
EREFKGLGDC LVKIYKSDGI KGLYQGFNVS VQGIIIYRAA YFGIYDTAKG
210 220 230 240 250
MLPDPKNTHI FISWMIAQSV TAVAGLTSYP FDTVRRRMMM QSGRKGTDIM
260 270 280 290
YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT
Length:298
Mass (Da):32,901
Last modified:January 23, 2007 - v3
Checksum:i6A59204B987EFE35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12771 mRNA. Translation: BAA02238.1.
BC059108 mRNA. Translation: AAH59108.1.
PIRiI56602.
RefSeqiNP_476443.1. NM_057102.1.
UniGeneiRn.102263.

Genome annotation databases

EnsembliENSRNOT00000015085; ENSRNOP00000015913; ENSRNOG00000039980.
GeneIDi25176.
KEGGirno:25176.
UCSCiRGD:620353. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12771 mRNA. Translation: BAA02238.1.
BC059108 mRNA. Translation: AAH59108.1.
PIRiI56602.
RefSeqiNP_476443.1. NM_057102.1.
UniGeneiRn.102263.

3D structure databases

ProteinModelPortaliQ09073.
SMRiQ09073. Positions 2-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247232. 1 interaction.
IntActiQ09073. 3 interactions.
MINTiMINT-4596867.
STRINGi10116.ENSRNOP00000015913.

PTM databases

iPTMnetiQ09073.
PhosphoSiteiQ09073.

Proteomic databases

PaxDbiQ09073.
PRIDEiQ09073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015085; ENSRNOP00000015913; ENSRNOG00000039980.
GeneIDi25176.
KEGGirno:25176.
UCSCiRGD:620353. rat.

Organism-specific databases

CTDi292.
RGDi620353. Slc25a5.

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiQ09073.
KOiK05863.
OMAiCFARTYK.
OrthoDBiEOG7T1RBR.
PhylomeDBiQ09073.
TreeFamiTF300743.

Enzyme and pathway databases

ReactomeiR-RNO-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiQ09073.

Gene expression databases

GenevisibleiQ09073. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of cDNA clones and a genomic clone encoding rat mitochondrial adenine nucleotide translocator."
    Shinohara Y., Kamida M., Yamazaki N., Terada H.
    Biochim. Biophys. Acta 1152:192-196(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. Bienvenut W.V., von Kriegsheim A.F., Kolch W.
    Submitted (AUG-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-31; 34-43; 73-80 AND 273-280, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Pheochromocytoma.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADT2_RAT
AccessioniPrimary (citable) accession number: Q09073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.