Reviewed, UniProtKB/Swiss-Prot Q09064 (UREE_HELPY)

Names and origin

Protein names

Recommended name:
    Urease accessory protein ureE

Gene names

Name:	ureE
Ordered Locus Names:	HP_0070

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly By similarity.
Subcellular location	Cytoplasm HAMAP MF_00822.
Sequence similarities	Belongs to the ureE family.

Ontologies

Keywords
Biological process	Nickel insertion Virulence
Cellular component	Cytoplasm
Ligand	Nickel
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	enzyme active site formation Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW protein complex assembly Inferred from electronic annotation. Source: InterPro protein folding Inferred from electronic annotation. Source: InterPro urea metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel ion binding Inferred from electronic annotation. Source: HAMAP unfolded protein binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 170	170	Urease accessory protein ureE HAMAP MF_00822		PRO_0000067633
Experimental info
	Sequence conflict	7	1	V → I in AAA25023. Ref.1
	Sequence conflict	22	1	H → Y in AAA25023. Ref.1
	Sequence conflict	47	1	I → V in AAA25023. Ref.1
	Sequence conflict	57	1	L → F in AAA25023. Ref.1
	Sequence conflict	169	1	V → M in AAA25023. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q09064-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 2B5FBBE3D0B21B3E	FASTA	170	19,382
	10 20 30 40 50 60 MIIERLVGNL RDLNPLDFSV DHVDLEWFET RKKIARFKTR QGKDIAIRLK DAPKLGLSQG 70 80 90 100 110 120 DILFKEEKEI IAVNILDSEV IHIQAKSVAE VAKICYEIGN RHAALYYGES QFEFKTPFEK 130 140 150 160 170 PTLALLEKLG VQNRVLSSKL DSKERLTVSM PHSEPNFKVS LASDFKVVVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of Helicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions." Cussac V., Ferrero R.L., Labigne A. J. Bacteriol. 174:2466-2473(1992) [PubMed: 1313413] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 85P.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[3]	"Bacterial factors that mediate colonization of the stomach and virulence of Helicobacter pylori." Clyne M., Dolan B., Reeves E.P. FEMS Microbiol. Lett. 268:135-143(2007) [PubMed: 17313591] [Abstract] Cited for: REVIEW ON VIRULENCE OF H.PYLORI.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M84338 Genomic DNA. Translation: AAA25023.1. AE000511 Genomic DNA. Translation: AAD07133.1.
PIR	B41834.
RefSeq	NP_206870.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3132N.
Genome annotation databases
GeneID	898943.
GenomeReviews	Gene locus HP_0070 in contig AE000511_GR.
KEGG	hpy:HP0070.
NMPDR	fig|85962.1.peg.68.
TIGR	HP_0070.
Phylogenomic databases
HOGENOM	HBG501812.
OMA	DSEVIHI.
Family and domain databases
HAMAP	MF_00822. [Tree]
InterPro	IPR012406. Ureas_acces_UreE. IPR007864. UreE_C. IPR004029. UreE_N. [Graphical view]
Gene3D	G3DSA:3.30.70.790. UreE_C. 1 hit.
Pfam	PF05194. UreE_C. 1 hit. PF02814. UreE_N. 1 hit. [Graphical view]
PIRSF	PIRSF036402. Ureas_acces_UreE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UREE_HELPY

Accession

Primary (citable) accession number: Q09064

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 1, 1997
Last modified:	December 15, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)