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Protein

Trefoil factor 2

Gene

Tff2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.

GO - Molecular functioni

  • CXCR4 chemokine receptor binding Source: RGD
  • growth factor activity Source: UniProtKB-KW
  • structural molecule activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 2
Alternative name(s):
Spasmolytic polypeptide
Short name:
SP
Gene namesi
Name:Tff2
Synonyms:Sml1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620709 Tff2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002346324 – 129Trefoil factor 2Add BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 127PROSITE-ProRule annotation
Disulfide bondi31 ↔ 58PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi52 ↔ 69PROSITE-ProRule annotation
Disulfide bondi81 ↔ 107PROSITE-ProRule annotation
Disulfide bondi91 ↔ 106PROSITE-ProRule annotation
Disulfide bondi101 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ09030

Expressioni

Tissue specificityi

Expressed in the digestive tract, where it was found predominantly in the stomach with highest expression in the antrum. It is secreted predominantly from antral mucous cells into the lumen of the gastrointestinal tract.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001537

Structurei

3D structure databases

ProteinModelPortaliQ09030
SMRiQ09030
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 73P-type 1PROSITE-ProRule annotationAdd BLAST45
Domaini79 – 122P-type 2PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IZEH Eukaryota
ENOG410Y3PX LUCA
HOGENOMiHOG000253928
HOVERGENiHBG004363
InParanoidiQ09030
KOiK22453
PhylomeDBiQ09030

Family and domain databases

CDDicd00111 Trefoil, 2 hits
InterProiView protein in InterPro
IPR017994 P_trefoil_chordata
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF00088 Trefoil, 2 hits
PRINTSiPR00680 PTREFOIL
SMARTiView protein in SMART
SM00018 PD, 2 hits
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 2 hits
PS51448 P_TREFOIL_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRGAPLLV VVLVLGLHAL AEGEKPSPCR CSRMTPSNRK NCGFPGITSD
60 70 80 90 100
QCFNLGCCFD SSVAGVPWCF HPLPNQASEQ CVMEVSAREN CGYPGISPED
110 120
CASRHCCFSN LIFEVPWCFF PQSVDDCHY
Length:129
Mass (Da):14,077
Last modified:October 1, 1994 - v1
Checksum:i005D0848F64F92D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97255 mRNA Translation: AAA19025.1
PIRiI53637
RefSeqiNP_446296.1, NM_053844.1
UniGeneiRn.34367

Genome annotation databases

GeneIDi116592
KEGGirno:116592
UCSCiRGD:620709 rat

Similar proteinsi

Entry informationi

Entry nameiTFF2_RAT
AccessioniPrimary (citable) accession number: Q09030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health