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Protein

Trefoil factor 2

Gene

Tff2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.

GO - Molecular functioni

  • structural molecule activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 2
Alternative name(s):
Spasmolytic polypeptide
Short name:
SP
Gene namesi
Name:Tff2
Synonyms:Sml1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620709. Tff2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 129106Trefoil factor 2PRO_0000023463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 127PROSITE-ProRule annotation
Disulfide bondi31 ↔ 58PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi52 ↔ 69PROSITE-ProRule annotation
Disulfide bondi81 ↔ 107PROSITE-ProRule annotation
Disulfide bondi91 ↔ 106PROSITE-ProRule annotation
Disulfide bondi101 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ09030.

Expressioni

Tissue specificityi

Expressed in the digestive tract, where it was found predominantly in the stomach with highest expression in the antrum. It is secreted predominantly from antral mucous cells into the lumen of the gastrointestinal tract.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001537.

Structurei

3D structure databases

ProteinModelPortaliQ09030.
SMRiQ09030. Positions 24-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 7345P-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini79 – 12244P-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 P-type (trefoil) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IZEH. Eukaryota.
ENOG410Y3PX. LUCA.
HOGENOMiHOG000253928.
HOVERGENiHBG004363.
InParanoidiQ09030.
PhylomeDBiQ09030.

Family and domain databases

Gene3Di4.10.110.10. 2 hits.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 2 hits.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 2 hits.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 2 hits.
PROSITEiPS00025. P_TREFOIL_1. 2 hits.
PS51448. P_TREFOIL_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRGAPLLV VVLVLGLHAL AEGEKPSPCR CSRMTPSNRK NCGFPGITSD
60 70 80 90 100
QCFNLGCCFD SSVAGVPWCF HPLPNQASEQ CVMEVSAREN CGYPGISPED
110 120
CASRHCCFSN LIFEVPWCFF PQSVDDCHY
Length:129
Mass (Da):14,077
Last modified:October 1, 1994 - v1
Checksum:i005D0848F64F92D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97255 mRNA. Translation: AAA19025.1.
PIRiI53637.
RefSeqiNP_446296.1. NM_053844.1.
UniGeneiRn.34367.

Genome annotation databases

GeneIDi116592.
KEGGirno:116592.
UCSCiRGD:620709. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97255 mRNA. Translation: AAA19025.1.
PIRiI53637.
RefSeqiNP_446296.1. NM_053844.1.
UniGeneiRn.34367.

3D structure databases

ProteinModelPortaliQ09030.
SMRiQ09030. Positions 24-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001537.

Proteomic databases

PaxDbiQ09030.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116592.
KEGGirno:116592.
UCSCiRGD:620709. rat.

Organism-specific databases

CTDi7032.
RGDi620709. Tff2.

Phylogenomic databases

eggNOGiENOG410IZEH. Eukaryota.
ENOG410Y3PX. LUCA.
HOGENOMiHOG000253928.
HOVERGENiHBG004363.
InParanoidiQ09030.
PhylomeDBiQ09030.

Miscellaneous databases

PROiQ09030.

Family and domain databases

Gene3Di4.10.110.10. 2 hits.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 2 hits.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 2 hits.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 2 hits.
PROSITEiPS00025. P_TREFOIL_1. 2 hits.
PS51448. P_TREFOIL_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Spasmolytic polypeptide: a trefoil peptide secreted by rat gastric mucous cells."
    Jeffrey G.P., Oates P.S., Wang T.C., Babyatsky M.W., Brand S.J.
    Gastroenterology 106:336-345(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Gastric antrum.

Entry informationi

Entry nameiTFF2_RAT
AccessioniPrimary (citable) accession number: Q09030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.