Q09006 (STM1A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Stathmin-1-A

Alternative name(s):
Stathmin clone XO35

Gene names

Name:

stmn1-a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules By similarity.
Subunit structure	Binds to two alpha/beta-tubulin heterodimers By similarity.
Subcellular location	Cytoplasm › cytoskeleton.
Tissue specificity	Ubiquitous. Mostly abundant in brain and oocytes.
Developmental stage	Accumulates during oogenesis and remains stable as a maternal product throughout early development.
Post-translational modification	Different phosphorylated forms, from unphosphorylated to highly phosphorylated, are found in the mature egg. Progressive dephosphorylation from the mid-blastula to the tailbud stage.
Sequence similarities	Belongs to the stathmin family. Contains 1 SLD (stathmin-like) domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	regulation of microtubule polymerization or depolymerization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	Stathmin-1-A		PRO_0000182394
Regions
	Domain	4 – 145	142	SLD
	Coiled coil	40 – 135	96	Potential
Amino acid modifications
	Modified residue	16	1	Phosphoserine By similarity
	Modified residue	25	1	Phosphoserine By similarity
	Modified residue	39	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q09006 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: B9FE2D403C25C0F1	FASTA	145	16,789
	10 20 30 40 50 60 MCDSDIKVKQ LEKRASGQAF ELILSPPSMD AAPDLSITSP KKKECSLEEI QKKLEAAEER 70 80 90 100 110 120 RKLHEAEILK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTTKMETIKE NREAQIAAKL 130 140 ERLREKDKKV EEIRKGKECK EPSEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Stathmin gene family: phylogenetic conservation and developmental regulation in Xenopus." Maucuer A., Moreau J., Mechali M., Sobel A. J. Biol. Chem. 268:16420-16429(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Oocyte.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X71431 mRNA. Translation: CAA50562.1. BC073451 mRNA. Translation: AAH73451.1.
PIR	I51706.
RefSeq	NP_001081627.1. NM_001088158.1.
UniGene	Xl.4704.
3D structure databases
ProteinModelPortal	Q09006.
SMR	Q09006. Positions 6-141.
ModBase	Search...
Proteomic databases
PRIDE	Q09006.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397962.
KEGG	xla:397962.
Organism-specific databases
CTD	397962.
Xenbase	XB-GENE-6252151. stmn1.
Phylogenomic databases
HOVERGEN	HBG054037.
KO	K04381.
Family and domain databases
InterPro	IPR000956. Stathmin_fam. [Graphical view]
PANTHER	PTHR10104. PTHR10104. 1 hit.
Pfam	PF00836. Stathmin. 1 hit. [Graphical view]
PIRSF	PIRSF002285. Stathmin. 1 hit.
PRINTS	PR00345. STATHMIN.
SUPFAM	SSF101494. Stathmin. 1 hit.
PROSITE	PS00563. STATHMIN_1. 1 hit. PS01041. STATHMIN_2. 1 hit. PS51663. STATHMIN_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

STM1A_XENLA

Accession

Primary (citable) accession number: Q09006
Secondary accession number(s): Q6GNQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program