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Protein

D-alanine--D-alanine ligase

Gene

STAUR_3779

Organism
Stigmatella aurantiaca (strain DW4/3-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR378806:GCZI-3779-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:STAUR_3779Imported
ORF Names:STIAU_5187Imported
OrganismiStigmatella aurantiaca (strain DW4/3-1)Imported
Taxonomic identifieri378806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeArchangiaceaeStigmatella
Proteomesi
  • UP000032702 Componenti: Unassembled WGS sequence
  • UP000001351 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi378806.STAUR_3779.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 318ATP-graspInterPro annotationAdd BLAST211

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108PB3. Bacteria.
COG1181. LUCA.
KOiK01921.
OMAiVGYRAKW.
OrthoDBiPOG091H1LUD.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR011095. Dala_Dala_lig_C.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08QR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPPSKIAI LHYQLDGDPV DPVVLQVGES LRKLGHQPSF IAVSDRVFDI
60 70 80 90 100
LQEIERSGCD LVFNLCETFA EDYRLEVNVA ALMEMARVKF TGSGTAGLLL
110 120 130 140 150
AQDKILTKQL LEYHEIPTPD FATFDGSTVE TNGDLAFPLI VKPARSDASI
160 170 180 190 200
GIGGKSLVNS WEQLTDRVRE IRKELRDEAL AEEFIQGREV YVGIIGTKEL
210 220 230 240 250
PEILPIVELD FGNWDKDKPT ISDREVKFGP ETEGSPKLVI ARDISPVLRQ
260 270 280 290 300
RVERAALLAY RALKLQDYAR IDLRISEQDD PYILEVNPNP YLEDKGELAL
310 320 330 340
AAREKGLSYT QLIGRILDSA GHRYGLMKKP APTAQDSATA PAMG
Length:344
Mass (Da):38,184
Last modified:October 31, 2006 - v1
Checksum:i7C0E364D423B2DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002271 Genomic DNA. Translation: ADO71567.1.
AAMD01000202 Genomic DNA. Translation: EAU62830.1.
RefSeqiWP_002643294.1. NZ_AAMD01000202.1.

Genome annotation databases

EnsemblBacteriaiADO71567; ADO71567; STAUR_3779.
EAU62830; EAU62830; STIAU_5187.
KEGGisur:STAUR_3779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002271 Genomic DNA. Translation: ADO71567.1.
AAMD01000202 Genomic DNA. Translation: EAU62830.1.
RefSeqiWP_002643294.1. NZ_AAMD01000202.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi378806.STAUR_3779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO71567; ADO71567; STAUR_3779.
EAU62830; EAU62830; STIAU_5187.
KEGGisur:STAUR_3779.

Phylogenomic databases

eggNOGiENOG4108PB3. Bacteria.
COG1181. LUCA.
KOiK01921.
OMAiVGYRAKW.
OrthoDBiPOG091H1LUD.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciSAUR378806:GCZI-3779-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR011095. Dala_Dala_lig_C.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ08QR9_STIAD
AccessioniPrimary (citable) accession number: Q08QR9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.