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Protein
Submitted name:

Dual oxidase 1

Gene

duox

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi806 – 817PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • defense response to fungus Source: ZFIN
  • hydrogen peroxide biosynthetic process Source: ZFIN
  • leukocyte migration involved in inflammatory response Source: ZFIN
  • macrophage chemotaxis Source: ZFIN
  • neutrophil chemotaxis Source: ZFIN
  • response to bacterium Source: ZFIN
  • response to oxidative stress Source: InterPro
  • response to wounding Source: ZFIN

Keywordsi

Molecular functionOxidoreductaseSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Protein family/group databases

PeroxiBasei4063. DrDuOx.

Names & Taxonomyi

Protein namesi
Submitted name:
Dual oxidase 1Imported
Gene namesi
Name:duoxImported
Synonyms:duox1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-091117-14. duox.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei574 – 598HelicalSequence analysisAdd BLAST25
Transmembranei1001 – 1024HelicalSequence analysisAdd BLAST24
Transmembranei1044 – 1065HelicalSequence analysisAdd BLAST22
Transmembranei1093 – 1120HelicalSequence analysisAdd BLAST28
Transmembranei1140 – 1165HelicalSequence analysisAdd BLAST26
Transmembranei1177 – 1199HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ08JS2.

Structurei

3D structure databases

ProteinModelPortaliQ08JS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini793 – 828EF-handInterPro annotationAdd BLAST36
Domaini829 – 864EF-handInterPro annotationAdd BLAST36
Domaini1226 – 1332FAD-binding FR-typeInterPro annotationAdd BLAST107

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0039. Eukaryota.
ENOG410XNZY. LUCA.
HOGENOMiHOG000231774.
HOVERGENiHBG080428.
PhylomeDBiQ08JS2.

Family and domain databases

CDDicd09820. dual_peroxidase_like. 1 hit.
cd00051. EFh. 2 hits.
Gene3Di1.10.640.10. 1 hit.
InterProiView protein in InterPro
IPR034818. DUOX2.
IPR034821. DUOX_peroxidase.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR013112. FAD-bd_8.
IPR017927. Fd_Rdtase_FAD-bd.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR017938. Riboflavin_synthase-like_b-brl.
PANTHERiPTHR11972:SF121. PTHR11972:SF121. 1 hit.
PfamiView protein in Pfam
PF03098. An_peroxidase. 1 hit.
PF00036. EF-hand_1. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
PRINTSiPR00457. ANPEROXIDASE.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF48113. SSF48113. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51384. FAD_FR. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q08JS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GAYSAITWEV QRYDGWYNNL ADHDRGAADA SLVRLYPAQY MDGVYLARQE
60 70 80 90 100
PHLPNPRRIS TTAMSGQSGL LSHKNRSVLS VAFGYHVWSE ISESRRAGCP
110 120 130 140 150
PEFMHIKVQK DDPVFVSNSS QPVLLQFQRA DWDTSTGKSP NNPRTQVNHV
160 170 180 190 200
TAWIDGSSIY GSSSSWSDAL REFSGGRLSS SSSRDMPRRS SNGYLMWSSP
210 220 230 240 250
DPSSGPDSGS QELYEFGNAW ANENIFSVTE GIIWFRYHNY LASKLHKEHP
260 270 280 290 300
SWSDEELFQH ARKRVIATFQ NIAFYEWLPA FLGTHVTSYP GYQKYVDPGI
310 320 330 340 350
SVEFEAAAVR FGLTLAPPGV YKRNRTCHYR SVVNDDASKS PGLRLCNTFW
360 370 380 390 400
NRNNPHLQSS LDVDELIMGM ASQIAEREDN IIVEDLRDYM YGPLRFSRSD
410 420 430 440 450
AVALTIQRGR DFGLPSYNQI REALSMAPVN SFEDINPKLK DTKLLKELAD
460 470 480 490 500
LYENDISRLE LFVGGLLETQ EGPGPVFSTI ILDQFERIRN ADRFWFENKQ
510 520 530 540 550
NGLFTEEEIK AIRNTTFHDV LLDVTSAEKG DIQRSVFFWK NGDPCPQPQP
560 570 580 590 600
IRASDLQPCT KAFSMSYFDD SSKVGFGVTV VVLFLFPVVS YIVASAVAQV
610 620 630 640 650
RTARFKRFQQ KRSGSTKHKE PAHGTTASEW LGHNTAPRQV TLAFSEKKVF
660 670 680 690 700
QTFDENGSPL SSHSLGNQDH LXVIVSNDHQ HRALLLKIPK EYDLVLFFED
710 720 730 740 750
GVQRSEFLSL LRSELEGRIQ SLTVMEKSEK EMLCDAVTRE QRGKIVETFF
760 770 780 790 800
KHAFSKVLDI DKSDAGDLSS RTREALQCEL TRAEFASVLG LKSDSLFVES
810 820 830 840 850
MFTLADKDGN GYLSFQEFLD VIVIFMTGTS EEKSKLLFST HDIKGDGFLS
860 870 880 890 900
KEEFTSLLRS FIDISGALSK SQADDGIAAM LQTAGLYNKD RFSWEDFHFL
910 920 930 940 950
LRDHSAQLNI KGMEVLGKKK LGRQHKVSFI RKNSSSSSVE ELTHTPEEEH
960 970 980 990 1000
GQELRQRQTK KAGQSQAKLY VRPQRERFNR NPVQQCVQQF KRFIENYRRH
1010 1020 1030 1040 1050
IICTVVIYAI SAGLALERCI YYGLQAHSSG IPETSMVDVL VSRGSAAAIS
1060 1070 1080 1090 1100
FLFPYMLLTV CRNLITMCRE TFLNRYIPFD AAIDLHRQMA ATALILSVVH
1110 1120 1130 1140 1150
SLGHLVNVYI FCISDLSILA CLFPKVFSNN GSELPMKWTF WFFKTVPGIT
1160 1170 1180 1190 1200
GVILLLIFAF MYVFASHYFR RISFRGFWIT HHLYVLIYVL TVVHGSYGLL
1210 1220 1230 1240 1250
QQPRFHIYLI PPGLLFLLDK LISLSRKKVE IPVLKAELLL SDVTMLEFKR
1260 1270 1280 1290 1300
PQGFVYRSGQ WVRIACLTLG TDEYHPFTLT SAPHEETLSL HIRAAGPWTS
1310 1320 1330 1340 1350
KLREAYSPEK HQELGGLPKL YLDGPFGEGH QEWTDFEVSV LVGAGIGVTP
1360 1370 1380 1390 1400
FASILKDLVF KSSVKFKFHC KKVYFLWVTR TQRQFEWLSD IIREVEDMDM
1410 1420 1430 1440 1450
QDLVSVHIYI TQLPEKFDLR TTMLYVCERH FQKVWNRSLF TGLRSVTHFG
1460 1470 1480 1490 1500
RPPFLAFLSS LQEVHPEVEK VGVFSCGPPG LTKNVEKACQ QMNKRDQTHF

VHHYENF
Length:1,507
Mass (Da):171,716
Last modified:October 31, 2006 - v1
Checksum:iF87A17BCCA7F5C8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB255050 mRNA. Translation: BAF33370.1.
UniGeneiDr.104171.

Similar proteinsi

Entry informationi

Entry nameiQ08JS2_DANRE
AccessioniPrimary (citable) accession number: Q08JS2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 5, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation