Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Deerpox virus (strain W-1170-84) (DPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921By similarity
Active sitei194 – 1941By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:DpV84gp040
OrganismiDeerpox virus (strain W-1170-84) (DPV)
Taxonomic identifieri305676 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeCervidpoxvirusunclassified Cervidpoxvirus
Virus hostiOdocoileus hemionus (Mule deer) (Black-tailed deer) [TaxID: 9872]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Poly(A) polymerase catalytic subunitPRO_0000308930Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ08FE1.
SMRiQ08FE1. Positions 7-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08FE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRHISEILE KYLGRIPSLT EYHTLKSQYK NIHRVNIFNK DIFISLIKKN
60 70 80 90 100
KKKFFSDIDT SVSEIKKLVF DYFTKQEQTY SIGKLYTIIE LQTILVTTYT
110 120 130 140 150
DILGVLTTKG PDIFSSNVQY NTSSMQKIAS DALNSMNIAT ISDKVMGRHN
160 170 180 190 200
VSSLVCNVNS LMEEYLRRHN KSCICYGSYS LHLLNPEIKY GDIDILQTNS
210 220 230 240 250
RTFLIDLAFL IKFITGYNVI LLKVPYLKNY MVLKDQNDSH IIDSFNIRQE
260 270 280 290 300
TMQHIPKVLI DNIYIVDPTI QLLSMLKMLS QIDRLEDLAK NPDKLTIRFA
310 320 330 340 350
TLLEYVRNKY GIILNGNSNN MPMPATIDIK KRIITVDTKY YNFAYDKCYV
360 370 380 390 400
YLDENSLSSD ILSLNADDAV DFENVSNSAF LVNDKTLYTY FSNTVLLSGN
410 420 430 440 450
DKIHEISSRG ISAHILIYQA LMKHDISIPL TDIVNSLIGR NKQPIYEIIP
460 470
RDKKTGKHGI IDIEKDIITH
Length:470
Mass (Da):54,089
Last modified:October 31, 2006 - v1
Checksum:i2AA5851274C44B4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY689437 Genomic DNA. Translation: ABI99025.1.
RefSeqiYP_002302381.1. NC_006967.1.

Genome annotation databases

GeneIDi7011871.
KEGGivg:7011871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY689437 Genomic DNA. Translation: ABI99025.1.
RefSeqiYP_002302381.1. NC_006967.1.

3D structure databases

ProteinModelPortaliQ08FE1.
SMRiQ08FE1. Positions 7-468.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7011871.
KEGGivg:7011871.

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPAP1_DPV84
AccessioniPrimary (citable) accession number: Q08FE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 31, 2006
Last modified: April 1, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.