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Protein

Sialic acid-binding Ig-like lectin 14

Gene

SIGLEC14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191Sialic acidBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 14
Short name:
Siglec-14
Gene namesi
ORF Names:UNQ294/PRO333
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32926. SIGLEC14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 358342ExtracellularSequence analysisAdd
BLAST
Transmembranei359 – 38123HelicalSequence analysisAdd
BLAST
Topological domaini382 – 39615CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi362 – 3621R → A: Loss of interaction with TYROBP. 1 Publication

Organism-specific databases

PharmGKBiPA162403331.

Polymorphism and mutation databases

BioMutaiSIGLEC14.
DMDMi121940125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 396380Sialic acid-binding Ig-like lectin 14PRO_0000309314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi164 ↔ 213PROSITE-ProRule annotation
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi274 ↔ 319PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08ET2.
PRIDEiQ08ET2.

Expressioni

Tissue specificityi

Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also detected in lung and testis.1 Publication

Gene expression databases

BgeeiQ08ET2.
CleanExiHS_SIGLEC14.

Organism-specific databases

HPAiHPA014377.

Interactioni

Subunit structurei

Interacts with TYROBP.1 Publication

Protein-protein interaction databases

IntActiQ08ET2. 1 interaction.
STRINGi9606.ENSP00000354090.

Structurei

3D structure databases

ProteinModelPortaliQ08ET2.
SMRiQ08ET2. Positions 20-233, 249-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 136118Ig-like V-typeAdd
BLAST
Domaini146 – 22984Ig-like C2-type 1Add
BLAST
Domaini236 – 33196Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ08ET2.
KOiK06549.
OMAiSCICVTE.
OrthoDBiEOG7JDQXC.
PhylomeDBiQ08ET2.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08ET2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW
60 70 80 90 100
YSSPPLYVYW FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN
110 120 130 140 150
CSLSIGDARM EDTGSYFFRV ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF
160 170 180 190 200
LEPLESGRPT RLSCSLPGSC EAGPPLTFSW TGNALSPLDP ETTRSSELTL
210 220 230 240 250
TPRPEDHGTN LTCQVKRQGA QVTTERTVQL NVSYAPQNLA ISIFFRNGTG
260 270 280 290 300
TALRILSNGM SVPIQEGQSL FLACTVDSNP PASLSWFREG KALNPSQTSM
310 320 330 340 350
SGTLELPNIG AREGGEFTCR VQHPLGSQHL SFILSVQRSS SSCICVTEKQ
360 370 380 390
QGSWPLVLTL IRGALMGAGF LLTYGLTWIY YTRCGGPQQS RAERPG
Length:396
Mass (Da):43,970
Last modified:October 31, 2006 - v1
Checksum:i1C2DF3C6D43C6CE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY854038 mRNA. Translation: AAX47338.1.
AY358369 mRNA. Translation: AAQ88735.1.
CCDSiCCDS42604.1.
RefSeqiNP_001092082.1. NM_001098612.1.
UniGeneiHs.707374.
Hs.741865.

Genome annotation databases

EnsembliENST00000360844; ENSP00000354090; ENSG00000254415.
GeneIDi100049587.
KEGGihsa:100049587.
UCSCiuc002pxf.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY854038 mRNA. Translation: AAX47338.1.
AY358369 mRNA. Translation: AAQ88735.1.
CCDSiCCDS42604.1.
RefSeqiNP_001092082.1. NM_001098612.1.
UniGeneiHs.707374.
Hs.741865.

3D structure databases

ProteinModelPortaliQ08ET2.
SMRiQ08ET2. Positions 20-233, 249-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ08ET2. 1 interaction.
STRINGi9606.ENSP00000354090.

Polymorphism and mutation databases

BioMutaiSIGLEC14.
DMDMi121940125.

Proteomic databases

PaxDbiQ08ET2.
PRIDEiQ08ET2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360844; ENSP00000354090; ENSG00000254415.
GeneIDi100049587.
KEGGihsa:100049587.
UCSCiuc002pxf.5. human.

Organism-specific databases

CTDi100049587.
GeneCardsiSIGLEC14.
HGNCiHGNC:32926. SIGLEC14.
HPAiHPA014377.
neXtProtiNX_Q08ET2.
PharmGKBiPA162403331.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ08ET2.
KOiK06549.
OMAiSCICVTE.
OrthoDBiEOG7JDQXC.
PhylomeDBiQ08ET2.
TreeFamiTF332441.

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Miscellaneous databases

ChiTaRSiSIGLEC14. human.
GenomeRNAii100049587.
PROiQ08ET2.

Gene expression databases

BgeeiQ08ET2.
CleanExiHS_SIGLEC14.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates."
    Angata T., Hayakawa T., Yamanaka M., Varki A., Nakamura M.
    FASEB J. 20:1964-1973(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TYROBP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-362.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-396.

Entry informationi

Entry nameiSIG14_HUMAN
AccessioniPrimary (citable) accession number: Q08ET2
Secondary accession number(s): Q6UXG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 31, 2006
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.