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Protein

Zinc finger protein 543

Gene

ZNF543

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 221C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 543
Gene namesi
Name:ZNF543
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25281. ZNF543.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178229.
PharmGKBiPA134914064.

Polymorphism and mutation databases

BioMutaiZNF543.
DMDMi313104258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868091 – 600Zinc finger protein 543Add BLAST600

Proteomic databases

MaxQBiQ08ER8.
PaxDbiQ08ER8.
PeptideAtlasiQ08ER8.
PRIDEiQ08ER8.

PTM databases

iPTMnetiQ08ER8.
PhosphoSitePlusiQ08ER8.

Expressioni

Gene expression databases

BgeeiENSG00000178229.
CleanExiHS_ZNF543.

Organism-specific databases

HPAiHPA029736.
HPA057665.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10226133,EBI-10172290

Protein-protein interaction databases

BioGridi125934. 2 interactors.
IntActiQ08ER8. 3 interactors.
STRINGi9606.ENSP00000322545.

Structurei

3D structure databases

ProteinModelPortaliQ08ER8.
SMRiQ08ER8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 80KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 221C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ08ER8.
KOiK09228.
OMAiSLGCPLF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ08ER8.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08ER8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAQVSVT FEDVAVTFTQ EEWGQLDAAQ RTLYQEVMLE TCGLLMSLGC
60 70 80 90 100
PLFKPELIYQ LDHRQELWMA TKDLSQSSYP GDNTKPKTTE PTFSHLALPE
110 120 130 140 150
EVLLQEQLTQ GASKNSQLGQ SKDQDGPSEM QEVHLKIGIG PQRGKLLEKM
160 170 180 190 200
SSERDGLGSD DGVCTKITQK QVSTEGDLYE CDSHGPVTDA LIREEKNSYK
210 220 230 240 250
CEECGKVFKK NALLVQHERI HTQVKPYECT ECGKTFSKST HLLQHLIIHT
260 270 280 290 300
GEKPYKCMEC GKAFNRRSHL TRHQRIHSGE KPYKCSECGK AFTHRSTFVL
310 320 330 340 350
HHRSHTGEKP FVCKECGKAF RDRPGFIRHY IIHTGEKPYE CIECGKAFNR
360 370 380 390 400
RSYLTWHQQI HTGVKPFECN ECGKAFCESA DLIQHYIIHT GEKPYKCMEC
410 420 430 440 450
GKAFNRRSHL KQHQRIHTGE KPYECSECGK AFTHCSTFVL HKRTHTGEKP
460 470 480 490 500
YECKECGKAF SDRADLIRHF SIHTGEKPYE CVECGKAFNR SSHLTRHQQI
510 520 530 540 550
HTGEKPYECI QCGKAFCRSA NLIRHSIIHT GEKPYECSEC GKAFNRGSSL
560 570 580 590 600
THHQRIHTGR NPTIVTDVGR PFMTAQTSVN IQELLLGKEF LNITTEENLW
Length:600
Mass (Da):68,404
Last modified:November 30, 2010 - v3
Checksum:iEB79C2956B980DED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti470F → L in BAD18681 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03217155P → A.2 PublicationsCorresponds to variant rs6510057dbSNPEnsembl.1
Natural variantiVAR_032172107Q → R.2 PublicationsCorresponds to variant rs8100491dbSNPEnsembl.1
Natural variantiVAR_032173246L → H.2 PublicationsCorresponds to variant rs1968090dbSNPEnsembl.1
Natural variantiVAR_032174287E → V.1 PublicationCorresponds to variant rs35238720dbSNPEnsembl.1
Natural variantiVAR_032175439V → D.Corresponds to variant rs10411486dbSNPEnsembl.1
Natural variantiVAR_032176573M → V.Corresponds to variant rs10410649dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131547 mRNA. Translation: BAD18681.1.
AC005261 Genomic DNA. No translation available.
BC101012 mRNA. Translation: AAI01013.1.
BC101013 mRNA. Translation: AAI01014.1.
BC101014 mRNA. Translation: AAI01015.1.
BC101015 mRNA. Translation: AAI01016.1.
AL834534 mRNA. Translation: CAD39190.1.
CCDSiCCDS33130.1.
RefSeqiNP_998763.2. NM_213598.3.
UniGeneiHs.202544.

Genome annotation databases

EnsembliENST00000321545; ENSP00000322545; ENSG00000178229.
GeneIDi125919.
KEGGihsa:125919.
UCSCiuc002qoi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131547 mRNA. Translation: BAD18681.1.
AC005261 Genomic DNA. No translation available.
BC101012 mRNA. Translation: AAI01013.1.
BC101013 mRNA. Translation: AAI01014.1.
BC101014 mRNA. Translation: AAI01015.1.
BC101015 mRNA. Translation: AAI01016.1.
AL834534 mRNA. Translation: CAD39190.1.
CCDSiCCDS33130.1.
RefSeqiNP_998763.2. NM_213598.3.
UniGeneiHs.202544.

3D structure databases

ProteinModelPortaliQ08ER8.
SMRiQ08ER8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125934. 2 interactors.
IntActiQ08ER8. 3 interactors.
STRINGi9606.ENSP00000322545.

PTM databases

iPTMnetiQ08ER8.
PhosphoSitePlusiQ08ER8.

Polymorphism and mutation databases

BioMutaiZNF543.
DMDMi313104258.

Proteomic databases

MaxQBiQ08ER8.
PaxDbiQ08ER8.
PeptideAtlasiQ08ER8.
PRIDEiQ08ER8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321545; ENSP00000322545; ENSG00000178229.
GeneIDi125919.
KEGGihsa:125919.
UCSCiuc002qoi.3. human.

Organism-specific databases

CTDi125919.
GeneCardsiZNF543.
HGNCiHGNC:25281. ZNF543.
HPAiHPA029736.
HPA057665.
MIMi616847. gene.
neXtProtiNX_Q08ER8.
OpenTargetsiENSG00000178229.
PharmGKBiPA134914064.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ08ER8.
KOiK09228.
OMAiSLGCPLF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ08ER8.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF543. human.
GenomeRNAii125919.
PROiQ08ER8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178229.
CleanExiHS_ZNF543.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN543_HUMAN
AccessioniPrimary (citable) accession number: Q08ER8
Secondary accession number(s): Q495U9
, Q495V0, Q6ZMP4, Q8NCX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.