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Protein

S-formylglutathione hydrolase

Gene

ESD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine hydrolase involved in the detoxification of formaldehyde.By similarity

Catalytic activityi

S-formylglutathione + H2O = glutathione + formate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Charge relay systemBy similarity1
Active sitei226Charge relay systemBy similarity1
Active sitei260Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-BTA-156590 Glutathione conjugation

Protein family/group databases

ESTHERibovin-estd A85-EsteraseD-FGH

Names & Taxonomyi

Protein namesi
Recommended name:
S-formylglutathione hydrolase (EC:3.1.2.12)
Short name:
FGH
Alternative name(s):
Esterase D
Gene namesi
Name:ESD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:28600 ESD

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003419652 – 282S-formylglutathione hydrolaseAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ08E20
PeptideAtlasiQ08E20
PRIDEiQ08E20

Expressioni

Gene expression databases

BgeeiENSBTAG00000003415

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004431

Structurei

3D structure databases

ProteinModelPortaliQ08E20
SMRiQ08E20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the esterase D family.Curated

Phylogenomic databases

eggNOGiKOG3101 Eukaryota
COG0627 LUCA
GeneTreeiENSGT00390000011864
HOGENOMiHOG000263929
HOVERGENiHBG001326
InParanoidiQ08E20
KOiK01070
OMAiEDHLRHH
OrthoDBiEOG091G0FIA
TreeFamiTF300793

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000801 Esterase_put
IPR014186 S-formylglutathione_hydrol
PANTHERiPTHR10061 PTHR10061, 1 hit
PfamiView protein in Pfam
PF00756 Esterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR02821 fghA_ester_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08E20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKQVSSSK CFGGLQKVFE HDSVELKCKM KFAVYLPPKA ETGKCPVLYW
60 70 80 90 100
LSGLTCTEQN FISKSGYHQA ASEHGLVVIA PDTSPRGCNI KGEEDSWDFG
110 120 130 140 150
TGAGFYVDAT EDLWKTNYRM YSYVTKELPQ LVNDNFPVDP QRMSVFGHSM
160 170 180 190 200
GGHGALICAL KNPGKYKSVS AFAPLCNPVL CRWGKKAFTG YLGTDQSKWE
210 220 230 240 250
AYDATYLVKS YPGPQLDILI DQGKEDEFLS DGQLLPDNFI AACTEKKIPV
260 270 280
VFRLQEGYDH SYYFIATFIA DHIRHHAKYL NA
Length:282
Mass (Da):31,548
Last modified:October 31, 2006 - v1
Checksum:i42CEC96886B147F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123461 mRNA Translation: AAI23462.1
RefSeqiNP_001069533.1, NM_001076065.1
XP_005213718.1, XM_005213661.2
XP_005213719.1, XM_005213662.3
UniGeneiBt.61889

Genome annotation databases

EnsembliENSBTAT00000004431; ENSBTAP00000004431; ENSBTAG00000003415
GeneIDi535653
KEGGibta:535653

Similar proteinsi

Entry informationi

Entry nameiESTD_BOVIN
AccessioniPrimary (citable) accession number: Q08E20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health