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Protein

S-formylglutathione hydrolase

Gene

ESD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Serine hydrolase involved in the detoxification of formaldehyde.By similarity

Catalytic activityi

S-formylglutathione + H2O = glutathione + formate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491Charge relay systemBy similarity
Active sitei226 – 2261Charge relay systemBy similarity
Active sitei260 – 2601Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-BTA-156590. Glutathione conjugation.

Protein family/group databases

ESTHERibovin-estd. A85-EsteraseD-FGH.

Names & Taxonomyi

Protein namesi
Recommended name:
S-formylglutathione hydrolase (EC:3.1.2.12)
Short name:
FGH
Alternative name(s):
Esterase D
Gene namesi
Name:ESD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 282281S-formylglutathione hydrolasePRO_0000341965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei4 – 41N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ08E20.
PeptideAtlasiQ08E20.
PRIDEiQ08E20.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004431.

Structurei

3D structure databases

ProteinModelPortaliQ08E20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the esterase D family.Curated

Phylogenomic databases

eggNOGiKOG3101. Eukaryota.
COG0627. LUCA.
GeneTreeiENSGT00390000011864.
HOGENOMiHOG000263929.
HOVERGENiHBG001326.
InParanoidiQ08E20.
KOiK01070.
OMAiSVELKCK.
OrthoDBiEOG7TF79G.
TreeFamiTF300793.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000801. Esterase_put.
IPR014186. S-formylglutathione_hydrol.
[Graphical view]
PANTHERiPTHR10061. PTHR10061. 1 hit.
PfamiPF00756. Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR02821. fghA_ester_D. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08E20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKQVSSSK CFGGLQKVFE HDSVELKCKM KFAVYLPPKA ETGKCPVLYW
60 70 80 90 100
LSGLTCTEQN FISKSGYHQA ASEHGLVVIA PDTSPRGCNI KGEEDSWDFG
110 120 130 140 150
TGAGFYVDAT EDLWKTNYRM YSYVTKELPQ LVNDNFPVDP QRMSVFGHSM
160 170 180 190 200
GGHGALICAL KNPGKYKSVS AFAPLCNPVL CRWGKKAFTG YLGTDQSKWE
210 220 230 240 250
AYDATYLVKS YPGPQLDILI DQGKEDEFLS DGQLLPDNFI AACTEKKIPV
260 270 280
VFRLQEGYDH SYYFIATFIA DHIRHHAKYL NA
Length:282
Mass (Da):31,548
Last modified:October 31, 2006 - v1
Checksum:i42CEC96886B147F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123461 mRNA. Translation: AAI23462.1.
RefSeqiNP_001069533.1. NM_001076065.1.
XP_005213718.1. XM_005213661.2.
XP_005213719.1. XM_005213662.3.
UniGeneiBt.61889.

Genome annotation databases

EnsembliENSBTAT00000004431; ENSBTAP00000004431; ENSBTAG00000003415.
GeneIDi535653.
KEGGibta:535653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123461 mRNA. Translation: AAI23462.1.
RefSeqiNP_001069533.1. NM_001076065.1.
XP_005213718.1. XM_005213661.2.
XP_005213719.1. XM_005213662.3.
UniGeneiBt.61889.

3D structure databases

ProteinModelPortaliQ08E20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004431.

Protein family/group databases

ESTHERibovin-estd. A85-EsteraseD-FGH.

Proteomic databases

PaxDbiQ08E20.
PeptideAtlasiQ08E20.
PRIDEiQ08E20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004431; ENSBTAP00000004431; ENSBTAG00000003415.
GeneIDi535653.
KEGGibta:535653.

Organism-specific databases

CTDi2098.

Phylogenomic databases

eggNOGiKOG3101. Eukaryota.
COG0627. LUCA.
GeneTreeiENSGT00390000011864.
HOGENOMiHOG000263929.
HOVERGENiHBG001326.
InParanoidiQ08E20.
KOiK01070.
OMAiSVELKCK.
OrthoDBiEOG7TF79G.
TreeFamiTF300793.

Enzyme and pathway databases

ReactomeiR-BTA-156590. Glutathione conjugation.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000801. Esterase_put.
IPR014186. S-formylglutathione_hydrol.
[Graphical view]
PANTHERiPTHR10061. PTHR10061. 1 hit.
PfamiPF00756. Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR02821. fghA_ester_D. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiESTD_BOVIN
AccessioniPrimary (citable) accession number: Q08E20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 31, 2006
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.