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Protein

Syndecan-1

Gene

SDC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-174800. Chylomicron-mediated lipid transport.
R-BTA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-BTA-2022928. HS-GAG biosynthesis.
R-BTA-2024096. HS-GAG degradation.
R-BTA-3000170. Syndecan interactions.
R-BTA-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-1
Short name:
SYND1
Alternative name(s):
CD_antigen: CD138
Gene namesi
Name:SDC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

  • Membrane Sequence analysis; Single-pass type I membrane protein Sequence analysis
  • Secreted By similarity
  • Secretedexosome By similarity

  • Note: Shedding of the ectodomain produces a soluble form.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 255233ExtracellularSequence analysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence analysisAdd
BLAST
Topological domaini277 – 31135CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 311289Syndecan-1PRO_0000290107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371O-linked (Xyl...) (chondroitin sulfate)By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Glycosylationi45 – 451O-linked (Xyl...) (heparan sulfate)By similarity
Glycosylationi47 – 471O-linked (Xyl...) (heparan sulfate)By similarity
Glycosylationi204 – 2041O-linked (Xyl...) (chondroitin sulfate)By similarity
Glycosylationi214 – 2141O-linked (Xyl...) (chondroitin sulfate)By similarity
Modified residuei286 – 2861PhosphoserineBy similarity

Post-translational modificationi

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei251 – 2522Cleavage of ectodomainSequence analysis

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ08DZ5.
PeptideAtlasiQ08DZ5.
PRIDEiQ08DZ5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011154.

Interactioni

Subunit structurei

Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014810.

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYWX. Eukaryota.
ENOG410Y2QY. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000133092.
HOVERGENiHBG017783.
InParanoidiQ08DZ5.
KOiK06257.
OMAiPTKQEEF.
OrthoDBiEOG091G0EYV.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031190. Syndecan-1.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF5. PTHR10915:SF5. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAALWLWL CALALRLQPA LLHSVAVNMP PEDQDGSGDD SDNFSGSGAG
60 70 80 90 100
ALPDITSSHT PSTWKDLGPV TTTATAPEPT SPDAIAASTT ILPTGEQPEG
110 120 130 140 150
GRAVLLAEVE PGLTAQKEAT HPPSETTLHP TTHSVSTARA TMAPGPATSH
160 170 180 190 200
PHRDVQPDHH ETSAPTGRGR MEPHRPHVEE GGPPATEKAA EEDPSTQIPV
210 220 230 240 250
GEGSGEQDFT FDLSGENAAG AAGEPGSRNG APEDPEATGA TGASQGLLDR
260 270 280 290 300
KEVLGGVIAG GLVGLIFAVC LVGFMLYRMK KKDEGSYSLE EPKQANGGAY
310
QKPTKQEEFY A
Length:311
Mass (Da):32,316
Last modified:October 31, 2006 - v1
Checksum:i31E163B82F35BBC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123495 mRNA. Translation: AAI23496.1.
RefSeqiNP_001069392.1. NM_001075924.1.
UniGeneiBt.46190.

Genome annotation databases

EnsembliENSBTAT00000014810; ENSBTAP00000014810; ENSBTAG00000011154.
GeneIDi529759.
KEGGibta:529759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123495 mRNA. Translation: AAI23496.1.
RefSeqiNP_001069392.1. NM_001075924.1.
UniGeneiBt.46190.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014810.

Proteomic databases

PaxDbiQ08DZ5.
PeptideAtlasiQ08DZ5.
PRIDEiQ08DZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014810; ENSBTAP00000014810; ENSBTAG00000011154.
GeneIDi529759.
KEGGibta:529759.

Organism-specific databases

CTDi6382.

Phylogenomic databases

eggNOGiENOG410IYWX. Eukaryota.
ENOG410Y2QY. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000133092.
HOVERGENiHBG017783.
InParanoidiQ08DZ5.
KOiK06257.
OMAiPTKQEEF.
OrthoDBiEOG091G0EYV.
TreeFamiTF320463.

Enzyme and pathway databases

ReactomeiR-BTA-174800. Chylomicron-mediated lipid transport.
R-BTA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-BTA-2022928. HS-GAG biosynthesis.
R-BTA-2024096. HS-GAG degradation.
R-BTA-3000170. Syndecan interactions.
R-BTA-975634. Retinoid metabolism and transport.

Gene expression databases

BgeeiENSBTAG00000011154.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031190. Syndecan-1.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF5. PTHR10915:SF5. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDC1_BOVIN
AccessioniPrimary (citable) accession number: Q08DZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.