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Protein

Syndecan-1

Gene

SDC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-BTA-2022928 HS-GAG biosynthesis
R-BTA-2024096 HS-GAG degradation
R-BTA-202733 Cell surface interactions at the vascular wall
R-BTA-3000170 Syndecan interactions
R-BTA-449836 Other interleukin signaling
R-BTA-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-1
Short name:
SYND1
Alternative name(s):
CD_antigen: CD138
Gene namesi
Name:SDC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:34378 SDC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 255ExtracellularSequence analysisAdd BLAST233
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 311CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029010723 – 311Syndecan-1Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45O-linked (Xyl...) (heparan sulfate) serineBy similarity1
Glycosylationi47O-linked (Xyl...) (heparan sulfate) serineBy similarity1
Glycosylationi204O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi214O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Modified residuei286PhosphoserineBy similarity1

Post-translational modificationi

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei251 – 252Cleavage of ectodomainSequence analysis2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ08DZ5
PeptideAtlasiQ08DZ5
PRIDEiQ08DZ5

Expressioni

Gene expression databases

BgeeiENSBTAG00000011154

Interactioni

Subunit structurei

Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014810

Structurei

3D structure databases

SMRiQ08DZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYWX Eukaryota
ENOG410Y2QY LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000133092
HOVERGENiHBG017783
InParanoidiQ08DZ5
KOiK06257
OMAiPTKQEEF
OrthoDBiEOG091G0EYV
TreeFamiTF320463

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031190 Syndecan-1
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF5 PTHR10915:SF5, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAALWLWL CALALRLQPA LLHSVAVNMP PEDQDGSGDD SDNFSGSGAG
60 70 80 90 100
ALPDITSSHT PSTWKDLGPV TTTATAPEPT SPDAIAASTT ILPTGEQPEG
110 120 130 140 150
GRAVLLAEVE PGLTAQKEAT HPPSETTLHP TTHSVSTARA TMAPGPATSH
160 170 180 190 200
PHRDVQPDHH ETSAPTGRGR MEPHRPHVEE GGPPATEKAA EEDPSTQIPV
210 220 230 240 250
GEGSGEQDFT FDLSGENAAG AAGEPGSRNG APEDPEATGA TGASQGLLDR
260 270 280 290 300
KEVLGGVIAG GLVGLIFAVC LVGFMLYRMK KKDEGSYSLE EPKQANGGAY
310
QKPTKQEEFY A
Length:311
Mass (Da):32,316
Last modified:October 31, 2006 - v1
Checksum:i31E163B82F35BBC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123495 mRNA Translation: AAI23496.1
RefSeqiNP_001069392.1, NM_001075924.1
UniGeneiBt.46190

Genome annotation databases

EnsembliENSBTAT00000014810; ENSBTAP00000014810; ENSBTAG00000011154
GeneIDi529759
KEGGibta:529759

Similar proteinsi

Entry informationi

Entry nameiSDC1_BOVIN
AccessioniPrimary (citable) accession number: Q08DZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health