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Protein

Transcription factor E2F6

Gene

E2F6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi50 – 129Sequence analysisAdd BLAST80

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor E2F6
Short name:
E2F-6
Gene namesi
Name:E2F6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002905831 – 285Transcription factor E2F6Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ08DY6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000048286.

Interactioni

Subunit structurei

Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028703.

Structurei

3D structure databases

ProteinModelPortaliQ08DY6.
SMRiQ08DY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 222DimerizationSequence analysisAdd BLAST93
Regioni143 – 164Leucine-zipperAdd BLAST22
Regioni173 – 285Transcription repressionBy similarityAdd BLAST113

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi95 – 129DEF boxAdd BLAST35

Sequence similaritiesi

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGiKOG2577. Eukaryota.
ENOG410XNYI. LUCA.
GeneTreeiENSGT00550000074403.
HOGENOMiHOG000112309.
HOVERGENiHBG002227.
InParanoidiQ08DY6.
KOiK09390.
OMAiSKNLIQW.
OrthoDBiEOG091G087U.
TreeFamiTF105566.

Family and domain databases

CDDicd14660. E2F_DD. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR015633. E2F.
IPR032198. E2F_CC-MB.
IPR003316. E2F_WHTH_DNA-bd_dom.
IPR015635. Transcription_factor_E2F6.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR12081. PTHR12081. 1 hit.
PTHR12081:SF53. PTHR12081:SF53. 1 hit.
PfamiView protein in Pfam
PF16421. E2F_CC-MB. 1 hit.
PF02319. E2F_TDP. 1 hit.
SMARTiView protein in SMART
SM01372. E2F_TDP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08DY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQRPARKL PSLLVDPAEE TVRRRCRDPI NVEGLLPSKI RINLEDNVQY
60 70 80 90 100
VSMRKALKVK RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK
110 120 130 140 150
RRVYDITNVL DGIDLVEKKS KNHIRWIGSD LSNFGAVPQQ KKLQEELSDL
160 170 180 190 200
SAMEDALDEL IKDCAQQLFE LTDDKENERL AYVTYQDIHS IQAFHEQIVI
210 220 230 240 250
AVKAPAETRL DVPAPKEDSI TVHIRSTKGP IDVYLCEVEQ GSHSSNKTSD
260 270 280
NVGTSSSKSK PLEHPQPEKE ENPPQQSEEV LEVSN
Length:285
Mass (Da):32,246
Last modified:October 31, 2006 - v1
Checksum:i00F205365E941FEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123506 mRNA. Translation: AAI23507.1.
RefSeqiNP_001070316.1. NM_001076848.1.
UniGeneiBt.7678.

Genome annotation databases

EnsembliENSBTAT00000028703; ENSBTAP00000028703; ENSBTAG00000048286.
GeneIDi514085.
KEGGibta:514085.

Similar proteinsi

Entry informationi

Entry nameiE2F6_BOVIN
AccessioniPrimary (citable) accession number: Q08DY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 31, 2006
Last modified: August 30, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families