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Protein

Growth/differentiation factor 10

Gene

GDF10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processOsteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 10
Short name:
GDF-10
Alternative name(s):
Bone morphogenetic protein 3B
Short name:
BMP-3B
Gene namesi
Name:GDF10
Synonyms:BMP3B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Organism-specific databases

VGNCiVGNC:29299 GDF10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
PropeptideiPRO_000028557134 – 368Sequence analysisAdd BLAST335
ChainiPRO_0000285572369 – 478Growth/differentiation factor 10Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi376 ↔ 443By similarity
Disulfide bondi405 ↔ 475By similarity
Disulfide bondi409 ↔ 477By similarity
Disulfide bondi442InterchainBy similarity
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08DX6
PRIDEiQ08DX6

Expressioni

Gene expression databases

BgeeiENSBTAG00000001019

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001351

Structurei

3D structure databases

ProteinModelPortaliQ08DX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000232003
HOVERGENiHBG004857
InParanoidiQ08DX6
KOiK05496
OMAiTSMQDSE
OrthoDBiEOG091G0WGP
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR017197 BMP3/BMP3B
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037403 BMP3/GDF10, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPARTSL GPGSQQLPLL SLLLLLLLRD ADGSHTAAAR PPPPAAADGL
60 70 80 90 100
AGDKNPQRSP GDVAAAQSPG AQDMVAVHML RLYEKYSRRG ARPGGGNTVR
110 120 130 140 150
SFRARLEVVN QKAVYFFNLT SMQDSEMILT ATFHFYSEPQ WPPAREVPCK
160 170 180 190 200
QRAKNASCRL LPPGPPARQH LLFRSLSQNT ATQGLLRGAM ALPPPPRGLW
210 220 230 240 250
QAKDISLIVK AARRDGELLL SAQLDSGEKD TGVPRLGPHA PYILIYANDL
260 270 280 290 300
AISEPNSVAV TLQRYDPFQA GDPEPGAAPN SSADPRVRRA TQATGPLQNN
310 320 330 340 350
ELPGLDERPA QAPHAQHYHK HELWPNPLRA LKPRPGRKDR RKKGQDVFMA
360 370 380 390 400
SSQVLDFDEK TMQKARKKQW DEPRVCSRRY LKVDFADIGW NEWIISPKSF
410 420 430 440 450
DAYYCSGACE FPMPKMVRPS NHATIQSIVR AVGIVPGIPE PCCVPDKMSS
460 470
LGVLFLDENR NVVLKVYPNM SVETCACR
Length:478
Mass (Da):52,626
Last modified:October 31, 2006 - v1
Checksum:i6296B1722A8AE9DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123524 mRNA Translation: AAI23525.1
RefSeqiNP_001069635.1, NM_001076167.2
UniGeneiBt.38634

Genome annotation databases

EnsembliENSBTAT00000001351; ENSBTAP00000001351; ENSBTAG00000001019
GeneIDi539510
KEGGibta:539510

Similar proteinsi

Entry informationi

Entry nameiGDF10_BOVIN
AccessioniPrimary (citable) accession number: Q08DX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 31, 2006
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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