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Protein

Growth/differentiation factor 10

Gene

GDF10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 10
Short name:
GDF-10
Alternative name(s):
Bone morphogenetic protein 3B
Short name:
BMP-3B
Gene namesi
Name:GDF10
Synonyms:BMP3B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Propeptidei34 – 368335Sequence analysisPRO_0000285571Add
BLAST
Chaini369 – 478110Growth/differentiation factor 10PRO_0000285572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence analysis
Disulfide bondi376 ↔ 443By similarity
Disulfide bondi405 ↔ 475By similarity
Disulfide bondi409 ↔ 477By similarity
Disulfide bondi442 – 442InterchainBy similarity
Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08DX6.
PRIDEiQ08DX6.

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001351.

Structurei

3D structure databases

ProteinModelPortaliQ08DX6.
SMRiQ08DX6. Positions 372-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiQ08DX6.
KOiK05496.
OMAiTSMQDSE.
OrthoDBiEOG70CR76.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPARTSL GPGSQQLPLL SLLLLLLLRD ADGSHTAAAR PPPPAAADGL
60 70 80 90 100
AGDKNPQRSP GDVAAAQSPG AQDMVAVHML RLYEKYSRRG ARPGGGNTVR
110 120 130 140 150
SFRARLEVVN QKAVYFFNLT SMQDSEMILT ATFHFYSEPQ WPPAREVPCK
160 170 180 190 200
QRAKNASCRL LPPGPPARQH LLFRSLSQNT ATQGLLRGAM ALPPPPRGLW
210 220 230 240 250
QAKDISLIVK AARRDGELLL SAQLDSGEKD TGVPRLGPHA PYILIYANDL
260 270 280 290 300
AISEPNSVAV TLQRYDPFQA GDPEPGAAPN SSADPRVRRA TQATGPLQNN
310 320 330 340 350
ELPGLDERPA QAPHAQHYHK HELWPNPLRA LKPRPGRKDR RKKGQDVFMA
360 370 380 390 400
SSQVLDFDEK TMQKARKKQW DEPRVCSRRY LKVDFADIGW NEWIISPKSF
410 420 430 440 450
DAYYCSGACE FPMPKMVRPS NHATIQSIVR AVGIVPGIPE PCCVPDKMSS
460 470
LGVLFLDENR NVVLKVYPNM SVETCACR
Length:478
Mass (Da):52,626
Last modified:October 31, 2006 - v1
Checksum:i6296B1722A8AE9DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123524 mRNA. Translation: AAI23525.1.
RefSeqiNP_001069635.1. NM_001076167.2.
UniGeneiBt.38634.

Genome annotation databases

EnsembliENSBTAT00000001351; ENSBTAP00000001351; ENSBTAG00000001019.
GeneIDi539510.
KEGGibta:539510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123524 mRNA. Translation: AAI23525.1.
RefSeqiNP_001069635.1. NM_001076167.2.
UniGeneiBt.38634.

3D structure databases

ProteinModelPortaliQ08DX6.
SMRiQ08DX6. Positions 372-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001351.

Proteomic databases

PaxDbiQ08DX6.
PRIDEiQ08DX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001351; ENSBTAP00000001351; ENSBTAG00000001019.
GeneIDi539510.
KEGGibta:539510.

Organism-specific databases

CTDi2662.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiQ08DX6.
KOiK05496.
OMAiTSMQDSE.
OrthoDBiEOG70CR76.
TreeFamiTF316134.

Miscellaneous databases

NextBioi20878036.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiGDF10_BOVIN
AccessioniPrimary (citable) accession number: Q08DX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 31, 2006
Last modified: February 17, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.