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Protein

Monoacylglycerol lipase ABHD12

Gene

ABHD12

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways.By similarity

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei246NucleophileBy similarity1
Active sitei333Charge relay systemBy similarity1
Active sitei372Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-BTA-426048 Arachidonate production from DAG

Protein family/group databases

ESTHERibovin-q08dw9 ABHD12-PHARC

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD12Curated (EC:3.1.1.23By similarity)
Alternative name(s):
2-arachidonoylglycerol hydrolase
Abhydrolase domain-containing protein 12
Gene namesi
Name:ABHD12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:25490 ABHD12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicBy similarityAdd BLAST74
Transmembranei75 – 95HelicalBy similarityAdd BLAST21
Topological domaini96 – 398ExtracellularBy similarityAdd BLAST303

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003758071 – 398Monoacylglycerol lipase ABHD12Add BLAST398

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ08DW9
PRIDEiQ08DW9

Expressioni

Gene expression databases

BgeeiENSBTAG00000001420

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001863

Structurei

3D structure databases

ProteinModelPortaliQ08DW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 29Poly-Ala4

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1552 Eukaryota
COG1073 LUCA
GeneTreeiENSGT00390000006625
HOGENOMiHOG000230822
InParanoidiQ08DW9
KOiK13704
OMAiWGPVEFH
OrthoDBiEOG091G0QYO
TreeFamiTF315122

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR026605 ABHD12
IPR022742 Hydrolase_4
PANTHERiPTHR12277:SF61 PTHR12277:SF61, 1 hit
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q08DW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKRTEPVAL EHERRTASGS PSAGPAAAAL DADCRLKQNL CLAGPGPAEP
60 70 80 90 100
RCAADAGMKR ALGRRKGLCF RLRKILFFVL GLYVAIPFLI KLCPGIQAKL
110 120 130 140 150
IFLNFVRVPY FIDLKRPQDQ GLNHTCNYYL QPEEDVTIGV WHTVPTVWWK
160 170 180 190 200
NAQGKDQMWY EDALSSSHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV
210 220 230 240 250
VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKVRSGDNPV YIWGHSLGTG
260 270 280 290 300
VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF
310 320 330 340 350
FLDPITSSGI QFANDENVKH ISCSLLILHA EDDPVVPFQL GRKLYNIAAP
360 370 380 390
SRSFRDFKVQ FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPGRQH
Length:398
Mass (Da):45,220
Last modified:October 31, 2006 - v1
Checksum:i9D1F27185776727F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123534 mRNA Translation: AAI23535.1
RefSeqiNP_001071584.1, NM_001078116.1
UniGeneiBt.2203

Genome annotation databases

EnsembliENSBTAT00000001863; ENSBTAP00000001863; ENSBTAG00000001420
GeneIDi768242
KEGGibta:768242

Similar proteinsi

Entry informationi

Entry nameiABD12_BOVIN
AccessioniPrimary (citable) accession number: Q08DW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health