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Protein

Monoacylglycerol lipase ABHD12

Gene

ABHD12

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways.By similarity

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei246 – 2461NucleophileBy similarity
Active sitei333 – 3331Charge relay systemBy similarity
Active sitei372 – 3721Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-BTA-426048. Arachidonate production from DAG.

Protein family/group databases

ESTHERibovin-q08dw9. AlphaBeta_hydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD12Curated (EC:3.1.1.23By similarity)
Alternative name(s):
2-arachidonoylglycerol hydrolase
Abhydrolase domain-containing protein 12
Gene namesi
Name:ABHD12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

  • Membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicBy similarityAdd
BLAST
Transmembranei75 – 9521HelicalBy similarityAdd
BLAST
Topological domaini96 – 398303ExtracellularBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Monoacylglycerol lipase ABHD12PRO_0000375807Add
BLAST

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ08DW9.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001863.

Structurei

3D structure databases

ProteinModelPortaliQ08DW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 294Poly-Ala

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000006625.
HOGENOMiHOG000230822.
InParanoidiQ08DW9.
KOiK13704.
OMAiKYPKGLD.
OrthoDBiEOG75TMCD.
TreeFamiTF315122.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR026605. ABHD12.
IPR022742. Hydrolase_4.
[Graphical view]
PANTHERiPTHR12277:SF61. PTHR12277:SF61. 1 hit.
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08DW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKRTEPVAL EHERRTASGS PSAGPAAAAL DADCRLKQNL CLAGPGPAEP
60 70 80 90 100
RCAADAGMKR ALGRRKGLCF RLRKILFFVL GLYVAIPFLI KLCPGIQAKL
110 120 130 140 150
IFLNFVRVPY FIDLKRPQDQ GLNHTCNYYL QPEEDVTIGV WHTVPTVWWK
160 170 180 190 200
NAQGKDQMWY EDALSSSHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV
210 220 230 240 250
VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKVRSGDNPV YIWGHSLGTG
260 270 280 290 300
VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF
310 320 330 340 350
FLDPITSSGI QFANDENVKH ISCSLLILHA EDDPVVPFQL GRKLYNIAAP
360 370 380 390
SRSFRDFKVQ FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPGRQH
Length:398
Mass (Da):45,220
Last modified:October 31, 2006 - v1
Checksum:i9D1F27185776727F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123534 mRNA. Translation: AAI23535.1.
RefSeqiNP_001071584.1. NM_001078116.1.
UniGeneiBt.2203.

Genome annotation databases

EnsembliENSBTAT00000001863; ENSBTAP00000001863; ENSBTAG00000001420.
GeneIDi768242.
KEGGibta:768242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123534 mRNA. Translation: AAI23535.1.
RefSeqiNP_001071584.1. NM_001078116.1.
UniGeneiBt.2203.

3D structure databases

ProteinModelPortaliQ08DW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001863.

Protein family/group databases

ESTHERibovin-q08dw9. AlphaBeta_hydrolase.

Proteomic databases

PaxDbiQ08DW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001863; ENSBTAP00000001863; ENSBTAG00000001420.
GeneIDi768242.
KEGGibta:768242.

Organism-specific databases

CTDi26090.

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000006625.
HOGENOMiHOG000230822.
InParanoidiQ08DW9.
KOiK13704.
OMAiKYPKGLD.
OrthoDBiEOG75TMCD.
TreeFamiTF315122.

Enzyme and pathway databases

ReactomeiR-BTA-426048. Arachidonate production from DAG.

Miscellaneous databases

NextBioi20918539.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR026605. ABHD12.
IPR022742. Hydrolase_4.
[Graphical view]
PANTHERiPTHR12277:SF61. PTHR12277:SF61. 1 hit.
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiABD12_BOVIN
AccessioniPrimary (citable) accession number: Q08DW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: October 31, 2006
Last modified: May 11, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.