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Protein

Trans-acting T-cell-specific transcription factor GATA-3

Gene

GATA3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 287GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri317 – 341GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processImmunity, Innate immunity, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-5689880. Ub-specific processing proteases.
R-BTA-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs.
R-BTA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-acting T-cell-specific transcription factor GATA-3
Alternative name(s):
GATA-binding factor 3
Gene namesi
Name:GATA3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895871 – 443Trans-acting T-cell-specific transcription factor GATA-3Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineBy similarity1
Modified residuei162PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ08DV0.
PRIDEiQ08DV0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017243.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022908.

Structurei

3D structure databases

ProteinModelPortaliQ08DV0.
SMRiQ08DV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni288 – 316Flexible linkerBy similarityAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi344 – 353YxKxHxxxRPBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi137 – 142Poly-Ser6
Compositional biasi322 – 326Poly-Thr5

Domaini

Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation (By similarity).By similarity
The YxKxHxxxRP motif is critical for DNA-binding and function.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 287GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri317 – 341GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiQ08DV0.
KOiK17895.
OMAiQRYPPTH.
OrthoDBiEOG091G0AUR.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiView protein in InterPro
IPR029521. GATA-3.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
PANTHERiPTHR10071:SF229. PTHR10071:SF229. 1 hit.
PfamiView protein in Pfam
PF00320. GATA. 2 hits.
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiView protein in SMART
SM00401. ZnF_GATA. 2 hits.
PROSITEiView protein in PROSITE
PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q08DV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LGHSYMDPAQ YPLPEEVDVL
60 70 80 90 100
FNIDGQGNHV PSYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG
110 120 130 140 150
KALGSHHTAS PWNLSPFSKT SIHHGSPGPL SVYPPASSSS LSAGHSSPHL
160 170 180 190 200
FTFPPTPPKD VSPDPSLSTP GSAGSGRQDE KECIKYQVPL PDSMKLESAH
210 220 230 240 250
PRGSMATLGG AAASAHHPIT TYPPYVPEYS SGLFPPSSLL GGSPTGFGCK
260 270 280 290 300
SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL
310 320 330 340 350
IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI
360 370 380 390 400
NRPLTMKKEG IQTRNRKMSS KSKKCKKVHD ALEDFPKSSS FNPAALSRHM
410 420 430 440
SSLSHISPFS HSSHMLTTPT PMHPPSSLSF GPHHPSSMVT AMG
Length:443
Mass (Da):47,807
Last modified:October 31, 2006 - v1
Checksum:i18B29EC8E4AC3F27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123555 mRNA. Translation: AAI23556.1.
RefSeqiNP_001070272.1. NM_001076804.1.
XP_005214184.1. XM_005214127.3.
UniGeneiBt.31666.

Genome annotation databases

EnsembliENSBTAT00000022908; ENSBTAP00000022908; ENSBTAG00000017243.
GeneIDi505169.
KEGGibta:505169.

Similar proteinsi

Entry informationi

Entry nameiGATA3_BOVIN
AccessioniPrimary (citable) accession number: Q08DV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 31, 2006
Last modified: September 27, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome