ID   NTF3_BOVIN              Reviewed;         253 AA.
AC   Q08DT3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   24-JAN-2024, entry version 107.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   Flags: Precursor;
GN   Name=NTF3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal spinal cord;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; BC123576; AAI23577.1; -; mRNA.
DR   RefSeq; NP_001071456.1; NM_001077988.2.
DR   RefSeq; XP_015326804.1; XM_015471318.1.
DR   RefSeq; XP_015326805.1; XM_015471319.1.
DR   AlphaFoldDB; Q08DT3; -.
DR   SMR; Q08DT3; -.
DR   STRING; 9913.ENSBTAP00000040469; -.
DR   GlyCosmos; Q08DT3; 1 site, No reported glycans.
DR   PaxDb; 9913-ENSBTAP00000040469; -.
DR   Ensembl; ENSBTAT00000013493.6; ENSBTAP00000040469.3; ENSBTAG00000010223.6.
DR   GeneID; 532393; -.
DR   KEGG; bta:532393; -.
DR   CTD; 4908; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010223; -.
DR   VGNC; VGNC:32299; NTF3.
DR   eggNOG; ENOG502R4FK; Eukaryota.
DR   GeneTree; ENSGT00390000007725; -.
DR   HOGENOM; CLU_059942_1_1_1; -.
DR   InParanoid; Q08DT3; -.
DR   OMA; ILLYVMF; -.
DR   TreeFam; TF106463; -.
DR   Reactome; R-BTA-9034013; NTF3 activates NTRK3 signaling.
DR   Reactome; R-BTA-9034793; Activated NTRK3 signals through PLCG1.
DR   Reactome; R-BTA-9603381; Activated NTRK3 signals through PI3K.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000010223; Expressed in trachea and 77 other cell types or tissues.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IBA:GO_Central.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR   GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR   GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl.
DR   GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..134
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000321573"
FT   CHAIN           135..253
FT                   /note="Neurotrophin-3"
FT                   /id="PRO_0000321574"
FT   REGION          62..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        148..213
FT                   /evidence="ECO:0000250"
FT   DISULFID        191..242
FT                   /evidence="ECO:0000250"
FT   DISULFID        201..244
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   253 AA;  28861 MW;  D245B08A07ABD78F CRC64;
     MSILFYVMFL AYLRGVQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
     STLPKAEAPP REPAKSEFQP VTAMGPELLR QQRRYSSPRV LLSDSTPLEP PPLYLMEDYV
     GSPVAANRTS RRKRYAEHKS HRGEYSVCDS ESLWVTDKSS AIDIRGHQVT VLGEIKTGNS
     PVKQYFYETR CKEARPVKNG CRGIDDKHWN SQCKTSQTYV RALTSENNKL VGWRWIRIDT
     SCVCALSRKI GRT
//