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Protein

Neurotrophin-3

Gene

NTF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Gene namesi
Name:NTF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:32299. NTF3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000032157319 – 134By similarityAdd BLAST116
ChainiPRO_0000321574135 – 253Neurotrophin-3Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi148 ↔ 213By similarity
Disulfide bondi191 ↔ 242By similarity
Disulfide bondi201 ↔ 244By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08DT3.
PRIDEiQ08DT3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010223.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040469.

Structurei

3D structure databases

ProteinModelPortaliQ08DT3.
SMRiQ08DT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHMM. Eukaryota.
ENOG410XRRK. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiQ08DT3.
KOiK04356.
OMAiEFQPMIA.
OrthoDBiEOG091G0GHL.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiView protein in Pfam
PF00243. NGF. 1 hit.
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052. Nerve_growth_factor-rel. 1 hit.
SMARTiView protein in SMART
SM00140. NGF. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILFYVMFL AYLRGVQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPP REPAKSEFQP VTAMGPELLR QQRRYSSPRV
110 120 130 140 150
LLSDSTPLEP PPLYLMEDYV GSPVAANRTS RRKRYAEHKS HRGEYSVCDS
160 170 180 190 200
ESLWVTDKSS AIDIRGHQVT VLGEIKTGNS PVKQYFYETR CKEARPVKNG
210 220 230 240 250
CRGIDDKHWN SQCKTSQTYV RALTSENNKL VGWRWIRIDT SCVCALSRKI

GRT
Length:253
Mass (Da):28,861
Last modified:October 31, 2006 - v1
Checksum:iD245B08A07ABD78F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123576 mRNA. Translation: AAI23577.1.
RefSeqiNP_001071456.1. NM_001077988.2.
XP_015326804.1. XM_015471318.1.
XP_015326805.1. XM_015471319.1.
UniGeneiBt.56403.

Genome annotation databases

EnsembliENSBTAT00000013493; ENSBTAP00000040469; ENSBTAG00000010223.
GeneIDi532393.
KEGGibta:532393.

Similar proteinsi

Entry informationi

Entry nameiNTF3_BOVIN
AccessioniPrimary (citable) accession number: Q08DT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome