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Q08DT3 (NTF3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotrophin-3

Short name=NT-3
Gene names
Name:NTF3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to promote the survival of visceral and proprioceptive sensory neurons.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the NGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

activation of Ras GTPase activity

Inferred from electronic annotation. Source: Ensembl

activation of protein kinase B activity

Inferred from electronic annotation. Source: Ensembl

axon guidance

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from electronic annotation. Source: Ensembl

enteric nervous system development

Inferred from electronic annotation. Source: Ensembl

epidermis development

Inferred from electronic annotation. Source: Ensembl

glial cell fate determination

Inferred from electronic annotation. Source: Ensembl

induction of positive chemotaxis

Inferred from electronic annotation. Source: Ensembl

mechanoreceptor differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

nerve development

Inferred from electronic annotation. Source: Ensembl

neuromuscular synaptic transmission

Inferred from electronic annotation. Source: Ensembl

peripheral nervous system development

Inferred from electronic annotation. Source: Ensembl

positive regulation of actin cytoskeleton reorganization

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of receptor internalization

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

transmembrane receptor protein tyrosine kinase signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionchemoattractant activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 134116 By similarity
PRO_0000321573
Chain135 – 253119Neurotrophin-3
PRO_0000321574

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...) Potential
Disulfide bond148 ↔ 213 By similarity
Disulfide bond191 ↔ 242 By similarity
Disulfide bond201 ↔ 244 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q08DT3 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: D245B08A07ABD78F

FASTA25328,861
        10         20         30         40         50         60 
MSILFYVMFL AYLRGVQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 

        70         80         90        100        110        120 
STLPKAEAPP REPAKSEFQP VTAMGPELLR QQRRYSSPRV LLSDSTPLEP PPLYLMEDYV 

       130        140        150        160        170        180 
GSPVAANRTS RRKRYAEHKS HRGEYSVCDS ESLWVTDKSS AIDIRGHQVT VLGEIKTGNS 

       190        200        210        220        230        240 
PVKQYFYETR CKEARPVKNG CRGIDDKHWN SQCKTSQTYV RALTSENNKL VGWRWIRIDT 

       250 
SCVCALSRKI GRT 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal spinal cord.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC123576 mRNA. Translation: AAI23577.1.
RefSeqNP_001071456.1. NM_001077988.2.
XP_005207240.1. XM_005207183.1.
XP_005207241.1. XM_005207184.1.
XP_005207242.1. XM_005207185.1.
XP_005207243.1. XM_005207186.1.
XP_005207244.1. XM_005207187.1.
UniGeneBt.56403.

3D structure databases

ProteinModelPortalQ08DT3.
SMRQ08DT3. Positions 139-249.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000040469.

Proteomic databases

PRIDEQ08DT3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000013493; ENSBTAP00000040469; ENSBTAG00000010223.
GeneID532393.
KEGGbta:532393.

Organism-specific databases

CTD4908.

Phylogenomic databases

eggNOGNOG39844.
GeneTreeENSGT00390000007725.
HOGENOMHOG000231516.
HOVERGENHBG006494.
InParanoidQ08DT3.
KOK04356.
OMAYAEHKSH.
OrthoDBEOG7RBZ8Z.
TreeFamTF106463.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamPF00243. NGF. 1 hit.
[Graphical view]
PIRSFPIRSF001789. NGF. 1 hit.
PRINTSPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20875678.

Entry information

Entry nameNTF3_BOVIN
AccessionPrimary (citable) accession number: Q08DT3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 31, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families