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Q08DT3

- NTF3_BOVIN

UniProt

Q08DT3 - NTF3_BOVIN

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Protein
Neurotrophin-3
Gene
NTF3
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. activation of Ras GTPase activity Source: Ensembl
  3. activation of protein kinase B activity Source: Ensembl
  4. axon guidance Source: Ensembl
  5. brain development Source: Ensembl
  6. enteric nervous system development Source: Ensembl
  7. epidermis development Source: Ensembl
  8. glial cell fate determination Source: Ensembl
  9. induction of positive chemotaxis Source: Ensembl
  10. mechanoreceptor differentiation Source: Ensembl
  11. negative regulation of neuron apoptotic process Source: Ensembl
  12. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  13. nerve development Source: Ensembl
  14. neuromuscular synaptic transmission Source: Ensembl
  15. peripheral nervous system development Source: Ensembl
  16. positive regulation of actin cytoskeleton reorganization Source: Ensembl
  17. positive regulation of cell migration Source: Ensembl
  18. positive regulation of cell proliferation Source: Ensembl
  19. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  20. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  21. positive regulation of receptor internalization Source: Ensembl
  22. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  23. smooth muscle cell differentiation Source: Ensembl
  24. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Gene namesi
Name:NTF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Propeptidei19 – 134116 By similarity
PRO_0000321573Add
BLAST
Chaini135 – 253119Neurotrophin-3
PRO_0000321574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi148 ↔ 213 By similarity
Disulfide bondi191 ↔ 242 By similarity
Disulfide bondi201 ↔ 244 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ08DT3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040469.

Structurei

3D structure databases

ProteinModelPortaliQ08DT3.
SMRiQ08DT3. Positions 139-249.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39844.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiQ08DT3.
KOiK04356.
OMAiYAEHKSH.
OrthoDBiEOG7RBZ8Z.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DT3-1 [UniParc]FASTAAdd to Basket

« Hide

MSILFYVMFL AYLRGVQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK    50
QMVDVKENYQ STLPKAEAPP REPAKSEFQP VTAMGPELLR QQRRYSSPRV 100
LLSDSTPLEP PPLYLMEDYV GSPVAANRTS RRKRYAEHKS HRGEYSVCDS 150
ESLWVTDKSS AIDIRGHQVT VLGEIKTGNS PVKQYFYETR CKEARPVKNG 200
CRGIDDKHWN SQCKTSQTYV RALTSENNKL VGWRWIRIDT SCVCALSRKI 250
GRT 253
Length:253
Mass (Da):28,861
Last modified:October 31, 2006 - v1
Checksum:iD245B08A07ABD78F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123576 mRNA. Translation: AAI23577.1.
RefSeqiNP_001071456.1. NM_001077988.2.
XP_005207240.1. XM_005207183.1.
XP_005207241.1. XM_005207184.1.
XP_005207242.1. XM_005207185.1.
XP_005207243.1. XM_005207186.1.
XP_005207244.1. XM_005207187.1.
UniGeneiBt.56403.

Genome annotation databases

EnsembliENSBTAT00000013493; ENSBTAP00000040469; ENSBTAG00000010223.
GeneIDi532393.
KEGGibta:532393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123576 mRNA. Translation: AAI23577.1 .
RefSeqi NP_001071456.1. NM_001077988.2.
XP_005207240.1. XM_005207183.1.
XP_005207241.1. XM_005207184.1.
XP_005207242.1. XM_005207185.1.
XP_005207243.1. XM_005207186.1.
XP_005207244.1. XM_005207187.1.
UniGenei Bt.56403.

3D structure databases

ProteinModelPortali Q08DT3.
SMRi Q08DT3. Positions 139-249.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000040469.

Proteomic databases

PRIDEi Q08DT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000013493 ; ENSBTAP00000040469 ; ENSBTAG00000010223 .
GeneIDi 532393.
KEGGi bta:532393.

Organism-specific databases

CTDi 4908.

Phylogenomic databases

eggNOGi NOG39844.
GeneTreei ENSGT00390000007725.
HOGENOMi HOG000231516.
HOVERGENi HBG006494.
InParanoidi Q08DT3.
KOi K04356.
OMAi YAEHKSH.
OrthoDBi EOG7RBZ8Z.
TreeFami TF106463.

Miscellaneous databases

NextBioi 20875678.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal spinal cord.

Entry informationi

Entry nameiNTF3_BOVIN
AccessioniPrimary (citable) accession number: Q08DT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 31, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3