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Q08DT3

- NTF3_BOVIN

UniProt

Q08DT3 - NTF3_BOVIN

Protein

Neurotrophin-3

Gene

NTF3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Seems to promote the survival of visceral and proprioceptive sensory neurons.

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. activation of protein kinase B activity Source: Ensembl
    3. activation of Ras GTPase activity Source: Ensembl
    4. axon guidance Source: Ensembl
    5. brain development Source: Ensembl
    6. enteric nervous system development Source: Ensembl
    7. epidermis development Source: Ensembl
    8. glial cell fate determination Source: Ensembl
    9. induction of positive chemotaxis Source: Ensembl
    10. mechanoreceptor differentiation Source: Ensembl
    11. negative regulation of neuron apoptotic process Source: Ensembl
    12. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    13. nerve development Source: Ensembl
    14. neuromuscular synaptic transmission Source: Ensembl
    15. peripheral nervous system development Source: Ensembl
    16. positive regulation of actin cytoskeleton reorganization Source: Ensembl
    17. positive regulation of cell migration Source: Ensembl
    18. positive regulation of cell proliferation Source: Ensembl
    19. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    20. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    21. positive regulation of receptor internalization Source: Ensembl
    22. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    23. smooth muscle cell differentiation Source: Ensembl
    24. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotrophin-3
    Short name:
    NT-3
    Gene namesi
    Name:NTF3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 134116By similarityPRO_0000321573Add
    BLAST
    Chaini135 – 253119Neurotrophin-3PRO_0000321574Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 213By similarity
    Disulfide bondi191 ↔ 242By similarity
    Disulfide bondi201 ↔ 244By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ08DT3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000040469.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08DT3.
    SMRiQ08DT3. Positions 139-249.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39844.
    GeneTreeiENSGT00390000007725.
    HOGENOMiHOG000231516.
    HOVERGENiHBG006494.
    InParanoidiQ08DT3.
    KOiK04356.
    OMAiYAEHKSH.
    OrthoDBiEOG7RBZ8Z.
    TreeFamiTF106463.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08DT3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSILFYVMFL AYLRGVQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK    50
    QMVDVKENYQ STLPKAEAPP REPAKSEFQP VTAMGPELLR QQRRYSSPRV 100
    LLSDSTPLEP PPLYLMEDYV GSPVAANRTS RRKRYAEHKS HRGEYSVCDS 150
    ESLWVTDKSS AIDIRGHQVT VLGEIKTGNS PVKQYFYETR CKEARPVKNG 200
    CRGIDDKHWN SQCKTSQTYV RALTSENNKL VGWRWIRIDT SCVCALSRKI 250
    GRT 253
    Length:253
    Mass (Da):28,861
    Last modified:October 31, 2006 - v1
    Checksum:iD245B08A07ABD78F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123576 mRNA. Translation: AAI23577.1.
    RefSeqiNP_001071456.1. NM_001077988.2.
    XP_005207240.1. XM_005207183.1.
    XP_005207241.1. XM_005207184.1.
    XP_005207242.1. XM_005207185.1.
    XP_005207243.1. XM_005207186.1.
    XP_005207244.1. XM_005207187.1.
    UniGeneiBt.56403.

    Genome annotation databases

    EnsembliENSBTAT00000013493; ENSBTAP00000040469; ENSBTAG00000010223.
    GeneIDi532393.
    KEGGibta:532393.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123576 mRNA. Translation: AAI23577.1 .
    RefSeqi NP_001071456.1. NM_001077988.2.
    XP_005207240.1. XM_005207183.1.
    XP_005207241.1. XM_005207184.1.
    XP_005207242.1. XM_005207185.1.
    XP_005207243.1. XM_005207186.1.
    XP_005207244.1. XM_005207187.1.
    UniGenei Bt.56403.

    3D structure databases

    ProteinModelPortali Q08DT3.
    SMRi Q08DT3. Positions 139-249.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000040469.

    Proteomic databases

    PRIDEi Q08DT3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013493 ; ENSBTAP00000040469 ; ENSBTAG00000010223 .
    GeneIDi 532393.
    KEGGi bta:532393.

    Organism-specific databases

    CTDi 4908.

    Phylogenomic databases

    eggNOGi NOG39844.
    GeneTreei ENSGT00390000007725.
    HOGENOMi HOG000231516.
    HOVERGENi HBG006494.
    InParanoidi Q08DT3.
    KOi K04356.
    OMAi YAEHKSH.
    OrthoDBi EOG7RBZ8Z.
    TreeFami TF106463.

    Miscellaneous databases

    NextBioi 20875678.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal spinal cord.

    Entry informationi

    Entry nameiNTF3_BOVIN
    AccessioniPrimary (citable) accession number: Q08DT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3