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Protein

Neurotrophin-3

Gene

NTF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. growth factor activity Source: GO_Central
  3. neurotrophin p75 receptor binding Source: GO_Central

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. activation of protein kinase B activity Source: Ensembl
  3. activation of Ras GTPase activity Source: Ensembl
  4. axon guidance Source: Ensembl
  5. brain development Source: Ensembl
  6. cell-cell signaling Source: GO_Central
  7. enteric nervous system development Source: Ensembl
  8. epidermis development Source: Ensembl
  9. glial cell fate determination Source: Ensembl
  10. induction of positive chemotaxis Source: Ensembl
  11. mechanoreceptor differentiation Source: Ensembl
  12. negative regulation of neuron apoptotic process Source: GO_Central
  13. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  14. nerve development Source: Ensembl
  15. neuromuscular synaptic transmission Source: Ensembl
  16. neuron projection morphogenesis Source: GO_Central
  17. peripheral nervous system development Source: Ensembl
  18. positive regulation of actin cytoskeleton reorganization Source: Ensembl
  19. positive regulation of cell migration Source: Ensembl
  20. positive regulation of cell proliferation Source: Ensembl
  21. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  22. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  23. positive regulation of receptor internalization Source: Ensembl
  24. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  25. regulation of neuron differentiation Source: GO_Central
  26. smooth muscle cell differentiation Source: Ensembl
  27. transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Gene namesi
Name:NTF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: GO_Central
  2. extracellular region Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 134116By similarityPRO_0000321573Add
BLAST
Chaini135 – 253119Neurotrophin-3PRO_0000321574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi148 ↔ 213By similarity
Disulfide bondi191 ↔ 242By similarity
Disulfide bondi201 ↔ 244By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ08DT3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040469.

Structurei

3D structure databases

ProteinModelPortaliQ08DT3.
SMRiQ08DT3. Positions 139-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39844.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiQ08DT3.
KOiK04356.
OMAiYAEHKSH.
OrthoDBiEOG7RBZ8Z.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILFYVMFL AYLRGVQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPP REPAKSEFQP VTAMGPELLR QQRRYSSPRV
110 120 130 140 150
LLSDSTPLEP PPLYLMEDYV GSPVAANRTS RRKRYAEHKS HRGEYSVCDS
160 170 180 190 200
ESLWVTDKSS AIDIRGHQVT VLGEIKTGNS PVKQYFYETR CKEARPVKNG
210 220 230 240 250
CRGIDDKHWN SQCKTSQTYV RALTSENNKL VGWRWIRIDT SCVCALSRKI

GRT
Length:253
Mass (Da):28,861
Last modified:October 31, 2006 - v1
Checksum:iD245B08A07ABD78F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123576 mRNA. Translation: AAI23577.1.
RefSeqiNP_001071456.1. NM_001077988.2.
XP_005207240.1. XM_005207183.2.
XP_010803913.1. XM_010805611.1.
XP_010803914.1. XM_010805612.1.
UniGeneiBt.56403.

Genome annotation databases

EnsembliENSBTAT00000013493; ENSBTAP00000040469; ENSBTAG00000010223.
GeneIDi532393.
KEGGibta:532393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123576 mRNA. Translation: AAI23577.1.
RefSeqiNP_001071456.1. NM_001077988.2.
XP_005207240.1. XM_005207183.2.
XP_010803913.1. XM_010805611.1.
XP_010803914.1. XM_010805612.1.
UniGeneiBt.56403.

3D structure databases

ProteinModelPortaliQ08DT3.
SMRiQ08DT3. Positions 139-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040469.

Proteomic databases

PRIDEiQ08DT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013493; ENSBTAP00000040469; ENSBTAG00000010223.
GeneIDi532393.
KEGGibta:532393.

Organism-specific databases

CTDi4908.

Phylogenomic databases

eggNOGiNOG39844.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiQ08DT3.
KOiK04356.
OMAiYAEHKSH.
OrthoDBiEOG7RBZ8Z.
TreeFamiTF106463.

Miscellaneous databases

NextBioi20875678.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal spinal cord.

Entry informationi

Entry nameiNTF3_BOVIN
AccessioniPrimary (citable) accession number: Q08DT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 31, 2006
Last modified: March 4, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.