Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q08DQ2

- GFPT2_BOVIN

UniProt

Q08DQ2 - GFPT2_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Gene

GFPT2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (By similarity).By similarity

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21For GATase activityBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-KW
  3. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_226304. Synthesis of UDP-N-acetyl-glucosamine.
SABIO-RKQ08DQ2.
UniPathwayiUPA00113; UER00528.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase 2
Glutamine:fructose-6-phosphate amidotransferase 2
Short name:
GFAT 2
Short name:
GFAT2
Hexosephosphate aminotransferase 2
Gene namesi
Name:GFPT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 682681Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2PRO_0000287357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451Phosphoserine

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ08DQ2.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002867.

Structurei

3D structure databases

ProteinModelPortaliQ08DQ2.
SMRiQ08DQ2. Positions 322-670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 288287Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
BLAST
Domaini360 – 499140SIS 1PROSITE-ProRule annotationAdd
BLAST
Domaini531 – 672142SIS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation
Contains 2 SIS domains.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
GeneTreeiENSGT00390000010049.
HOGENOMiHOG000258898.
HOVERGENiHBG051724.
InParanoidiQ08DQ2.
KOiK00820.
OMAiRCLPEMI.
OrthoDBiEOG73NG2S.
TreeFamiTF300864.

Family and domain databases

Gene3Di3.60.20.10. 2 hits.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PfamiPF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 2 hits.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIFAYMNY RVPRTRKEIF ETLIKGLQRL EYRGYDSAGV AIDGNNNEVK
60 70 80 90 100
ERHIQLVKKR GNVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPS
110 120 130 140 150
AVNSHPQRSD KGNEFVVIHN GIITNYKDLR KFLESKGYEF ESETDTETIA
160 170 180 190 200
KLIKYVFDNR ETEDITFSTL VERVIQQLEG AFALVFKSIH YPGEAVATRR
210 220 230 240 250
GSPLLIGVRS KYKLSTEQIP VLYRTRNIEN VKNICKTRMK RLDSSTCLHA
260 270 280 290 300
VGNKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRLAS
310 320 330 340 350
DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN
360 370 380 390 400
TVLLGGLKDH LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE
410 420 430 440 450
LASDFLDRNT PVFRDDVCFF ISQSGETADT LLALRYCKDR RALTVGVTNT
460 470 480 490 500
VGSSISRETD CGVHINAGPE IGVASTKAYT SQFISLVMFG LMMSEDRISL
510 520 530 540 550
QNRRREIIHG LKSLPELIKE VLSLDEKIHD LALELYTQRS LLVMGRGYNY
560 570 580 590 600
ATCLEGALKI KEITYMHSEG ILAGELKHGP LALIDKQMPV IMVIMKDPCF
610 620 630 640 650
AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS
660 670 680
VIPLQLLSFH LAVLRGYDVD FPRNLAKSVT VE
Length:682
Mass (Da):77,081
Last modified:October 31, 2006 - v1
Checksum:i773A71B230746130
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123624 mRNA. Translation: AAI23625.1.
RefSeqiNP_001070351.1. NM_001076883.1.
UniGeneiBt.8781.

Genome annotation databases

EnsembliENSBTAT00000002867; ENSBTAP00000002867; ENSBTAG00000002215.
GeneIDi530101.
KEGGibta:530101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123624 mRNA. Translation: AAI23625.1 .
RefSeqi NP_001070351.1. NM_001076883.1.
UniGenei Bt.8781.

3D structure databases

ProteinModelPortali Q08DQ2.
SMRi Q08DQ2. Positions 322-670.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000002867.

Proteomic databases

PRIDEi Q08DQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000002867 ; ENSBTAP00000002867 ; ENSBTAG00000002215 .
GeneIDi 530101.
KEGGi bta:530101.

Organism-specific databases

CTDi 9945.

Phylogenomic databases

eggNOGi COG0449.
GeneTreei ENSGT00390000010049.
HOGENOMi HOG000258898.
HOVERGENi HBG051724.
InParanoidi Q08DQ2.
KOi K00820.
OMAi RCLPEMI.
OrthoDBi EOG73NG2S.
TreeFami TF300864.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00528 .
Reactomei REACT_226304. Synthesis of UDP-N-acetyl-glucosamine.
SABIO-RK Q08DQ2.

Miscellaneous databases

NextBioi 20875180.

Family and domain databases

Gene3Di 3.60.20.10. 2 hits.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
Pfami PF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 2 hits.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiGFPT2_BOVIN
AccessioniPrimary (citable) accession number: Q08DQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 31, 2006
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3