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Q08DQ2

- GFPT2_BOVIN

UniProt

Q08DQ2 - GFPT2_BOVIN

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Gene

GFPT2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins By similarity.By similarity

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21For GATase activityBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-KW
    3. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_226304. Synthesis of UDP-N-acetyl-glucosamine.
    SABIO-RKQ08DQ2.
    UniPathwayiUPA00113; UER00528.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC:2.6.1.16)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferase 2
    Glutamine:fructose-6-phosphate amidotransferase 2
    Short name:
    GFAT 2
    Short name:
    GFAT2
    Hexosephosphate aminotransferase 2
    Gene namesi
    Name:GFPT2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 682681Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2PRO_0000287357Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei245 – 2451Phosphoserine

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ08DQ2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000002867.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08DQ2.
    SMRiQ08DQ2. Positions 322-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 288287Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
    BLAST
    Domaini360 – 499140SIS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini531 – 672142SIS 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation
    Contains 2 SIS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    GeneTreeiENSGT00390000010049.
    HOGENOMiHOG000258898.
    HOVERGENiHBG051724.
    InParanoidiQ08DQ2.
    KOiK00820.
    OMAiRCLPEMI.
    OrthoDBiEOG73NG2S.
    TreeFamiTF300864.

    Family and domain databases

    Gene3Di3.60.20.10. 2 hits.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF00310. GATase_2. 2 hits.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 2 hits.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08DQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIFAYMNY RVPRTRKEIF ETLIKGLQRL EYRGYDSAGV AIDGNNNEVK    50
    ERHIQLVKKR GNVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPS 100
    AVNSHPQRSD KGNEFVVIHN GIITNYKDLR KFLESKGYEF ESETDTETIA 150
    KLIKYVFDNR ETEDITFSTL VERVIQQLEG AFALVFKSIH YPGEAVATRR 200
    GSPLLIGVRS KYKLSTEQIP VLYRTRNIEN VKNICKTRMK RLDSSTCLHA 250
    VGNKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRLAS 300
    DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN 350
    TVLLGGLKDH LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE 400
    LASDFLDRNT PVFRDDVCFF ISQSGETADT LLALRYCKDR RALTVGVTNT 450
    VGSSISRETD CGVHINAGPE IGVASTKAYT SQFISLVMFG LMMSEDRISL 500
    QNRRREIIHG LKSLPELIKE VLSLDEKIHD LALELYTQRS LLVMGRGYNY 550
    ATCLEGALKI KEITYMHSEG ILAGELKHGP LALIDKQMPV IMVIMKDPCF 600
    AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS 650
    VIPLQLLSFH LAVLRGYDVD FPRNLAKSVT VE 682
    Length:682
    Mass (Da):77,081
    Last modified:October 31, 2006 - v1
    Checksum:i773A71B230746130
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123624 mRNA. Translation: AAI23625.1.
    RefSeqiNP_001070351.1. NM_001076883.1.
    UniGeneiBt.8781.

    Genome annotation databases

    EnsembliENSBTAT00000002867; ENSBTAP00000002867; ENSBTAG00000002215.
    GeneIDi530101.
    KEGGibta:530101.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123624 mRNA. Translation: AAI23625.1 .
    RefSeqi NP_001070351.1. NM_001076883.1.
    UniGenei Bt.8781.

    3D structure databases

    ProteinModelPortali Q08DQ2.
    SMRi Q08DQ2. Positions 322-670.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000002867.

    Proteomic databases

    PRIDEi Q08DQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000002867 ; ENSBTAP00000002867 ; ENSBTAG00000002215 .
    GeneIDi 530101.
    KEGGi bta:530101.

    Organism-specific databases

    CTDi 9945.

    Phylogenomic databases

    eggNOGi COG0449.
    GeneTreei ENSGT00390000010049.
    HOGENOMi HOG000258898.
    HOVERGENi HBG051724.
    InParanoidi Q08DQ2.
    KOi K00820.
    OMAi RCLPEMI.
    OrthoDBi EOG73NG2S.
    TreeFami TF300864.

    Enzyme and pathway databases

    UniPathwayi UPA00113 ; UER00528 .
    Reactomei REACT_226304. Synthesis of UDP-N-acetyl-glucosamine.
    SABIO-RK Q08DQ2.

    Miscellaneous databases

    NextBioi 20875180.

    Family and domain databases

    Gene3Di 3.60.20.10. 2 hits.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF00310. GATase_2. 2 hits.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 2 hits.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Ascending colon.

    Entry informationi

    Entry nameiGFPT2_BOVIN
    AccessioniPrimary (citable) accession number: Q08DQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3