Reviewed, UniProtKB/Swiss-Prot Q08DP0 (PGM1_BOVIN)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase-1
      Short name=PGM 1
    EC=5.4.2.2
Alternative name(s):
    Glucose phosphomutase 1

Gene names

Name:

PGM1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	562 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This enzyme participates in both the breakdown and synthesis of glucose By similarity.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucomutase activity Inferred from sequence or structural similarity. Source: AgBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 562	561	Phosphoglucomutase-1		PRO_0000343708
Sites
	Active site	117	1	Phosphoserine intermediate By similarity
	Metal binding	117	1	Magnesium; via phosphate group By similarity
	Metal binding	288	1	Magnesium By similarity
	Metal binding	290	1	Magnesium By similarity
	Metal binding	292	1	Magnesium By similarity
Amino acid modifications
	Modified residue	115	1	Phosphothreonine By similarity
	Modified residue	117	1	Phosphoserine By similarity
	Modified residue	353	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q08DP0-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: D843620DD3815E8A	FASTA	562	61,589
	10 20 30 40 50 60 MVKIVTVKTK AYQDQKPGTS GLRKRVKVFQ SSSNYAENFI QSIISTVEPA QRQEATLVVG 70 80 90 100 110 120 GDGRFYMKEA IQLIVRIAAA NGIGRLVIGQ NGILSTPAVS CIIRKIKAIG GIILTASHNP 130 140 150 160 170 180 GGPNGDFGIK FNISNGGPAP EAITDKIFQI SKTIEEYAIC PDLHVDLGVL GKQQFDLENK 190 200 210 220 230 240 FKPFTVEIVD SVEAYATMLR NIFDFNALKE LLSGPNRLKI RIDAMHGVVG PYVKKILCEE 250 260 270 280 290 300 LGAPANSAVN CVPLEDFGGH HPDPNLTYAA DLVETMKTGE HDFGAAFDGD GDRNMILGKH 310 320 330 340 350 360 GFFVNPSDSV AVIAANIFSI PYFQQTGVRG FARSMPTSGA LDRVANATKI ALYETPTGWK 370 380 390 400 410 420 FFGNLMDASK LSLCGEESFG TGSDHIREKD GLWAVLAWLS ILATRKQSVE DILKDHWQKY 430 440 450 460 470 480 GRNFFTRYDY EEVEAEGANK MMKELEALIS DRSFVGKQFP VGDKVYTVEK IDNFEYSDPV 490 500 510 520 530 540 DGSISRNQGL RLLFADGSRI IFRLSGTGSA GATIRLYIDS YEKDLAKIYQ DPQVMLAPLI 550 560 SIALKVSQLQ EKTGRTAPTV IT

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal muscle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC123640 mRNA. Translation: AAI23641.1.
IPI	IPI00701643.
RefSeq	NP_001070371.1.
UniGene	Bt.59999
3D structure databases
SMR	Q08DP0. Positions 2-562.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000019011. Bos taurus. [Contig view]
GeneID	534402.
KEGG	bta:534402.
Phylogenomic databases
HOVERGEN	Q08DP0.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGM1_BOVIN

Accession

Primary (citable) accession number: Q08DP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	October 31, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)