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Protein
Submitted name:

TNF receptor superfamily member 21

Gene

TNFRSF21

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
TNF receptor superfamily member 21Imported
Submitted name:
Tumor necrosis factor receptor superfamily, member 21Imported
Gene namesi
Name:TNFRSF21Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:36166 TNFRSF21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi88 ↔ 103PROSITE-ProRule annotation
Disulfide bondi110 ↔ 128PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSBTAG00000020054

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026719

Structurei

3D structure databases

SMRiQ08DN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 128TNFR-CysInterPro annotationAdd BLAST42
Repeati87 – 128TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini412 – 495DeathInterPro annotationAdd BLAST84

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IHQ6 Eukaryota
ENOG410YYKW LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000136852
HOVERGENiHBG054218
KOiK05157
OMAiLMEDTAQ
OrthoDBiEOG091G03XW
TreeFamiTF331157

Family and domain databases

CDDicd08778 Death_TNFRSF21, 1 hit
cd10583 TNFRSF21, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022330 TNFR_21
IPR034037 TNFRSF21_death
IPR034034 TNFRSF21_N
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 1 hit
PRINTSiPR01971 TNFACTORR21
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q08DN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTFTSSSTA LASCSRMAGA TMIAGSFLLL GFLSTTRAQP EQKAPSLIGK
60 70 80 90 100
YHHVDRITGQ VLTCDKCPAG TYVSEHCTNI SLRVCSSCPT GTFTRHENGI
110 120 130 140 150
EKCHECSQRC PWPMIEKLPC TALTDRECTC PPGMFQSNGT CAPHTVCPVG
160 170 180 190 200
WGVRKKGTEM EDVRCKQCAR GTFSDVPSSV MRCRAYTDCL SQNMVVIKLG
210 220 230 240 250
TKEADNVCGP LPSSSSTAPP SPGTTSLSRP EHTEPHDVPS STLIPKGINS
260 270 280 290 300
TESNSSASVR PKVPSGTQEG TAPDNTSSAS GEEGVNKTFP KLQVANHQQG
310 320 330 340 350
PHHRHILKLL PSMEATGGEK SSTPIKGLKR GHPRQNPHKH FDINEHLPWM
360 370 380 390 400
IVLFLLLVLV VIVVCSIRKS SRTLKKGPRQ DPSAIVEKAG LKKSMAPTQN
410 420 430 440 450
REKWIYYCNG HGIDILKLVA AQVGSQWKDI YQFLCNASER EVAAFSNGYT
460 470 480 490 500
ADHERAYAAL QHWTIRGPEA SLAQLISALR QHRRNDVVEK IRGLMEDTAQ
510 520 530 540 550
LDTDKLALPM SPSPLGPSPI PSPNTKLENS TLLTVEPSPL DKNKGFFVDE
560 570 580 590 600
SEPLLRCDST SSGSSALSRN GSFITKEKKD TVLRQVRLDP CDLQPIFDDM
610 620 630 640 650
LHILNPEELR VIEETPQAED KLDRLFEIIG VKSQEASQTL LDSVYSHLPD

LL
Length:652
Mass (Da):71,305
Last modified:October 31, 2006 - v1
Checksum:i94D513EFFF04DD19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02055176 Genomic DNA No translation available.
DAAA02055177 Genomic DNA No translation available.
DAAA02055178 Genomic DNA No translation available.
DAAA02055179 Genomic DNA No translation available.
BC123657 mRNA Translation: AAI23658.1
RefSeqiNP_001070379.1, NM_001076911.1
UniGeneiBt.45971

Genome annotation databases

EnsembliENSBTAT00000026719; ENSBTAP00000026719; ENSBTAG00000020054
GeneIDi537922
KEGGibta:537922

Similar proteinsi

Entry informationi

Entry nameiQ08DN1_BOVIN
AccessioniPrimary (citable) accession number: Q08DN1
Secondary accession number(s): F1N407
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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