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Protein

PWWP domain-containing protein MUM1

Gene

MUM1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
PWWP domain-containing protein MUM1
Alternative name(s):
Mutated melanoma-associated antigen 1
Short name:
MUM-1
Gene namesi
Name:MUM1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

  • Nucleus By similarity

  • Note: Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641PWWP domain-containing protein MUM1PRO_0000295045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei156 – 1561PhosphoserineBy similarity
Modified residuei307 – 3071PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ08DK9.
PRIDEiQ08DK9.

Interactioni

Subunit structurei

Interacts with TP53BP1 (via BRCT domain); the interaction is not dependent on its phosphorylation status. Binds nucleosomes. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3) (in vitro) (By similarity).By similarity

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini343 – 40462PWWPAdd
BLAST

Domaini

The PWWP domain mediates the interaction with nucleosomes.

Sequence similaritiesi

Belongs to the MUM1 family.Curated
Contains 1 PWWP domain.Curated

Phylogenomic databases

eggNOGiENOG410IKQG. Eukaryota.
ENOG4111FZN. LUCA.
GeneTreeiENSGT00390000001700.
HOGENOMiHOG000232141.
HOVERGENiHBG054002.
InParanoidiQ08DK9.
OMAiQAIGWCV.
OrthoDBiEOG7BS494.
TreeFamiTF328774.

Family and domain databases

InterProiIPR033368. MUM1.
[Graphical view]
PANTHERiPTHR31333:SF4. PTHR31333:SF4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08DK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAKYVLCR WKKRLWPAKV LAGTEKSAKN KRKKGYFLNV QILSLDKKIK
60 70 80 90 100
VKSAEAKVLR KVHIEDIASS LASQDGTPAA PLEELTYRRS LRVALDVLNE
110 120 130 140 150
RQGSSSREGT TPRPPRVKPM EPASWPPKPS LSPSFLEDTA GSPGPTRRER
160 170 180 190 200
MSQRLSGLPA GEEDLEYGVD HKEGLKRSGG LDAPAMCSAS GGAQDREASR
210 220 230 240 250
KQQADWMTPL GKQGRNPAQG PHSGQRVAPS SEGAGQEDGE TGAGPAALCS
260 270 280 290 300
PPGGRDLSPL DGCPAEHLGL DSGQRPRAHM SPHSPAQLGP AEEAADTRPL
310 320 330 340 350
EEARPLSEEF MEPSAVNSLL EEDEDDEEPP RILLYHEPRS FEVGMLVWHK
360 370 380 390 400
YQKYPFWPAV VKSVRRRDKK ASVLFIEGNM NPRGRGISVL LRRLKHFDCK
410 420 430 440 450
EKQALLDEAK EDFAQAIGWC VSLITDYRVR LGCGSFAGSF LEYYAADISS
460 470 480 490 500
PVRKSIQQDV QGTRFPQLSG GDPEEPVAGS PQGRRPAYRK VLPDRSRAAR
510 520 530 540 550
DRANQKLVEY IVKARGAESH LRAILRNRKP SRWLKTFLSS GQYMTCVETY
560 570 580 590 600
LEDEEQLDLV VKYLQGVYKQ AGCQLLARGH GDGIRFILDV LLPEAIICAI
610 620 630 640
SAVDAVDYKT AEEKYIRGPA LSSREKEIFD NQLLEERNRR C
Length:641
Mass (Da):71,109
Last modified:October 31, 2006 - v1
Checksum:iC00733E698EFB692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123693 mRNA. Translation: AAI23694.1.
RefSeqiNP_001069090.1. NM_001075622.1.
XP_005209345.1. XM_005209288.1.
XP_005209346.1. XM_005209289.3.
UniGeneiBt.43056.

Genome annotation databases

EnsembliENSBTAT00000009840; ENSBTAP00000009840; ENSBTAG00000030839.
GeneIDi513471.
KEGGibta:513471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123693 mRNA. Translation: AAI23694.1.
RefSeqiNP_001069090.1. NM_001075622.1.
XP_005209345.1. XM_005209288.1.
XP_005209346.1. XM_005209289.3.
UniGeneiBt.43056.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ08DK9.
PRIDEiQ08DK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000009840; ENSBTAP00000009840; ENSBTAG00000030839.
GeneIDi513471.
KEGGibta:513471.

Organism-specific databases

CTDi84939.

Phylogenomic databases

eggNOGiENOG410IKQG. Eukaryota.
ENOG4111FZN. LUCA.
GeneTreeiENSGT00390000001700.
HOGENOMiHOG000232141.
HOVERGENiHBG054002.
InParanoidiQ08DK9.
OMAiQAIGWCV.
OrthoDBiEOG7BS494.
TreeFamiTF328774.

Miscellaneous databases

NextBioi20870871.

Family and domain databases

InterProiIPR033368. MUM1.
[Graphical view]
PANTHERiPTHR31333:SF4. PTHR31333:SF4. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiMUM1_BOVIN
AccessioniPrimary (citable) accession number: Q08DK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 31, 2006
Last modified: May 11, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.