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Protein

Mitochondrial basic amino acids transporter

Gene

SLC25A29

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-352230 Amino acid transport across the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial basic amino acids transporter
Alternative name(s):
Carnitine/acylcarnitine translocase-like
Short name:
CACT-like
Mitochondrial carnitine/acylcarnitine carrier protein CACL
Mitochondrial ornithine transporter 3
Solute carrier family 25 member 29
Gene namesi
Name:SLC25A29
Synonyms:ORNT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:34755 SLC25A29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei153 – 172Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290301 – 298Mitochondrial basic amino acids transporterAdd BLAST298

Proteomic databases

PaxDbiQ08DK7
PRIDEiQ08DK7

Expressioni

Gene expression databases

BgeeiENSBTAG00000013666

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018163

Structurei

3D structure databases

ProteinModelPortaliQ08DK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 86Solcar 1Add BLAST85
Repeati90 – 178Solcar 2Add BLAST89
Repeati185 – 275Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758 Eukaryota
ENOG410XS86 LUCA
GeneTreeiENSGT00700000104295
HOGENOMiHOG000168307
HOVERGENiHBG003500
InParanoidiQ08DK7
KOiK15109
OMAiGVCVSIQ
OrthoDBiEOG091G0HVE
TreeFamiTF351739

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q08DK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDFLAGCA GGVAGVLVGH PFDTVKVRLQ VQSVEKPQYR GTLHCFQAII
60 70 80 90 100
KQESVLGLYR GLGSPLLGLT FINALVFGVQ GNTLRALGRD SPLNQFLAGA
110 120 130 140 150
AAGAIQCVIC CPMELAKTRL QLQEAGPART YRGPLDCLAQ IYRQEGLRGV
160 170 180 190 200
NRGMVSTLLR ETPSFGVYFL TYDVLTRALG CEPGDRLLVP KLLLAGGTSG
210 220 230 240 250
IASWLSTYPV DVVKSRLQAD GLQGAPRYRG IVDCVQQSYR EEGWRVFTRG
260 270 280 290
LASTLLRAFP VNAATFATVT VVLSYARGEE ARLEGDAGSA ALAQPSSL
Length:298
Mass (Da):31,866
Last modified:October 31, 2006 - v1
Checksum:iCA830A3343DC23F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123695 mRNA Translation: AAI23696.1
RefSeqiNP_001071339.1, NM_001077871.1
UniGeneiBt.44159

Genome annotation databases

EnsembliENSBTAT00000018163; ENSBTAP00000018163; ENSBTAG00000013666
GeneIDi507686
KEGGibta:507686

Similar proteinsi

Entry informationi

Entry nameiMCATL_BOVIN
AccessioniPrimary (citable) accession number: Q08DK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health