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Protein

Mitochondrial basic amino acids transporter

Gene

SLC25A29

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial basic amino acids transporter
Alternative name(s):
Carnitine/acylcarnitine translocase-like
Short name:
CACT-like
Mitochondrial carnitine/acylcarnitine carrier protein CACL
Mitochondrial ornithine transporter 3
Solute carrier family 25 member 29
Gene namesi
Name:SLC25A29
Synonyms:ORNT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei153 – 17220Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei187 – 20721Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei255 – 27521Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Mitochondrial basic amino acids transporterPRO_0000329030Add
BLAST

Proteomic databases

PaxDbiQ08DK7.
PRIDEiQ08DK7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018163.

Structurei

3D structure databases

ProteinModelPortaliQ08DK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 8685Solcar 1Add
BLAST
Repeati90 – 17889Solcar 2Add
BLAST
Repeati185 – 27591Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ08DK7.
KOiK15109.
OMAiGTLHCFK.
OrthoDBiEOG7MSMP1.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08DK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDFLAGCA GGVAGVLVGH PFDTVKVRLQ VQSVEKPQYR GTLHCFQAII
60 70 80 90 100
KQESVLGLYR GLGSPLLGLT FINALVFGVQ GNTLRALGRD SPLNQFLAGA
110 120 130 140 150
AAGAIQCVIC CPMELAKTRL QLQEAGPART YRGPLDCLAQ IYRQEGLRGV
160 170 180 190 200
NRGMVSTLLR ETPSFGVYFL TYDVLTRALG CEPGDRLLVP KLLLAGGTSG
210 220 230 240 250
IASWLSTYPV DVVKSRLQAD GLQGAPRYRG IVDCVQQSYR EEGWRVFTRG
260 270 280 290
LASTLLRAFP VNAATFATVT VVLSYARGEE ARLEGDAGSA ALAQPSSL
Length:298
Mass (Da):31,866
Last modified:October 31, 2006 - v1
Checksum:iCA830A3343DC23F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123695 mRNA. Translation: AAI23696.1.
RefSeqiNP_001071339.1. NM_001077871.1.
UniGeneiBt.44159.

Genome annotation databases

EnsembliENSBTAT00000018163; ENSBTAP00000018163; ENSBTAG00000013666.
GeneIDi507686.
KEGGibta:507686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123695 mRNA. Translation: AAI23696.1.
RefSeqiNP_001071339.1. NM_001077871.1.
UniGeneiBt.44159.

3D structure databases

ProteinModelPortaliQ08DK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018163.

Proteomic databases

PaxDbiQ08DK7.
PRIDEiQ08DK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018163; ENSBTAP00000018163; ENSBTAG00000013666.
GeneIDi507686.
KEGGibta:507686.

Organism-specific databases

CTDi123096.

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ08DK7.
KOiK15109.
OMAiGTLHCFK.
OrthoDBiEOG7MSMP1.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiMCATL_BOVIN
AccessioniPrimary (citable) accession number: Q08DK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 31, 2006
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.