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Protein

Mitochondrial basic amino acids transporter

Gene

SLC25A29

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-BTA-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial basic amino acids transporter
Alternative name(s):
Carnitine/acylcarnitine translocase-like
Short name:
CACT-like
Mitochondrial carnitine/acylcarnitine carrier protein CACL
Mitochondrial ornithine transporter 3
Solute carrier family 25 member 29
Gene namesi
Name:SLC25A29
Synonyms:ORNT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei153 – 172Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290301 – 298Mitochondrial basic amino acids transporterAdd BLAST298

Proteomic databases

PaxDbiQ08DK7.
PRIDEiQ08DK7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013666.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018163.

Structurei

3D structure databases

ProteinModelPortaliQ08DK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 86Solcar 1Add BLAST85
Repeati90 – 178Solcar 2Add BLAST89
Repeati185 – 275Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ08DK7.
KOiK15109.
OMAiGVCVSIQ.
OrthoDBiEOG091G0HVE.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q08DK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDFLAGCA GGVAGVLVGH PFDTVKVRLQ VQSVEKPQYR GTLHCFQAII
60 70 80 90 100
KQESVLGLYR GLGSPLLGLT FINALVFGVQ GNTLRALGRD SPLNQFLAGA
110 120 130 140 150
AAGAIQCVIC CPMELAKTRL QLQEAGPART YRGPLDCLAQ IYRQEGLRGV
160 170 180 190 200
NRGMVSTLLR ETPSFGVYFL TYDVLTRALG CEPGDRLLVP KLLLAGGTSG
210 220 230 240 250
IASWLSTYPV DVVKSRLQAD GLQGAPRYRG IVDCVQQSYR EEGWRVFTRG
260 270 280 290
LASTLLRAFP VNAATFATVT VVLSYARGEE ARLEGDAGSA ALAQPSSL
Length:298
Mass (Da):31,866
Last modified:October 31, 2006 - v1
Checksum:iCA830A3343DC23F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123695 mRNA. Translation: AAI23696.1.
RefSeqiNP_001071339.1. NM_001077871.1.
UniGeneiBt.44159.

Genome annotation databases

EnsembliENSBTAT00000018163; ENSBTAP00000018163; ENSBTAG00000013666.
GeneIDi507686.
KEGGibta:507686.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMCATL_BOVIN
AccessioniPrimary (citable) accession number: Q08DK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 31, 2006
Last modified: June 7, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families