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Protein

Endophilin-B2

Gene

SH3GLB2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-B2
Alternative name(s):
SH3 domain-containing GRB2-like protein B2
Gene namesi
Name:SH3GLB2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002858431 – 395Endophilin-B2Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ08DK5.
PRIDEiQ08DK5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010626.

Interactioni

Subunit structurei

Homodimer, and heterodimer with SH3GLB1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014049.

Structurei

3D structure databases

ProteinModelPortaliQ08DK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 287BARPROSITE-ProRule annotationAdd BLAST264
Domaini335 – 395SH3PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 27Membrane-binding amphipathic helixBy similarityAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 132Sequence analysisAdd BLAST17
Coiled coili206 – 240Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the endophilin family.Curated
Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG3725. Eukaryota.
ENOG410XPA6. LUCA.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000232056.
HOVERGENiHBG054448.
InParanoidiQ08DK5.
KOiK11248.
OMAiQYMAEAA.
OrthoDBiEOG091G09WR.
TreeFamiTF313281.

Family and domain databases

Gene3Di1.20.1270.60. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08DK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE SLLARADSTK
60 70 80 90 100
NWTEKILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAE
110 120 130 140 150
AASELGPTTP YGKTLIKVAE AEKHLGAAER DFIHTASINF LTPLRNFLEG
160 170 180 190 200
DWKTISKERR LLQNRRLDLD ASKARLKKAK AAEAKATTVP DFQETRPRNY
210 220 230 240 250
ILSASASALW NDEVDKAEQE LRVAQTEFDR QAEVTRLLLE GISSTHVNHL
260 270 280 290 300
RCLHEFIESQ TTYYAQCYRH MLDLQKQLGR FPGTFVGTAE PASPPLSSTS
310 320 330 340 350
PTTTAATMPM GPSVADLAPP GEAALRLEEV APPASGTRKA RVLYDYEAAD
360 370 380 390
SSELALLADE LITVYSLPGM DPDWLIGERG NKKGKVPVTY LELLS
Length:395
Mass (Da):44,051
Last modified:October 31, 2006 - v1
Checksum:iCE6F3FFB22FAFD0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123698 mRNA. Translation: AAI23699.1.
RefSeqiNP_001070270.1. NM_001076802.1.
UniGeneiBt.3279.

Genome annotation databases

EnsembliENSBTAT00000014049; ENSBTAP00000014049; ENSBTAG00000010626.
GeneIDi504750.
KEGGibta:504750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123698 mRNA. Translation: AAI23699.1.
RefSeqiNP_001070270.1. NM_001076802.1.
UniGeneiBt.3279.

3D structure databases

ProteinModelPortaliQ08DK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014049.

Proteomic databases

PaxDbiQ08DK5.
PRIDEiQ08DK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014049; ENSBTAP00000014049; ENSBTAG00000010626.
GeneIDi504750.
KEGGibta:504750.

Organism-specific databases

CTDi56904.

Phylogenomic databases

eggNOGiKOG3725. Eukaryota.
ENOG410XPA6. LUCA.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000232056.
HOVERGENiHBG054448.
InParanoidiQ08DK5.
KOiK11248.
OMAiQYMAEAA.
OrthoDBiEOG091G09WR.
TreeFamiTF313281.

Gene expression databases

BgeeiENSBTAG00000010626.

Family and domain databases

Gene3Di1.20.1270.60. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHLB2_BOVIN
AccessioniPrimary (citable) accession number: Q08DK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.