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Protein

Mitochondrial glutamate carrier 1

Gene

SLC25A22

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-428643. Organic anion transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glutamate carrier 1
Short name:
GC-1
Alternative name(s):
Glutamate/H(+) symporter 1
Solute carrier family 25 member 22
Gene namesi
Name:SLC25A22
Synonyms:GC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei292 – 312Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830511 – 322Mitochondrial glutamate carrier 1Add BLAST322

Proteomic databases

PaxDbiQ08DK4.
PRIDEiQ08DK4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001229.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001624.

Structurei

3D structure databases

ProteinModelPortaliQ08DK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 93Solcar 1Add BLAST88
Repeati101 – 214Solcar 2Add BLAST114
Repeati223 – 312Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0750. Eukaryota.
ENOG410Y240. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000168308.
HOVERGENiHBG039469.
InParanoidiQ08DK4.
KOiK15107.
OMAiAQRKLMP.
OrthoDBiEOG091G08GT.
TreeFamiTF313209.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom_sf.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q08DK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKQISLPA KLINGGIAGL IGVTCVFPID LAKTRLQNQQ NGQRMYTSMS
60 70 80 90 100
DCLIKTIRSE GYFGMYRGAA VNLTLVTPEK AIKLAANDFF RYQLSKDGQQ
110 120 130 140 150
LTLFKEMLAG CGAGTCQVIV TTPMEMLKIQ LQDAGRLAAQ RKILSAQAQL
160 170 180 190 200
SGQGSAQPSV EAPATPRPTA TQLTRDLLRS RGIAGLYKGL GATLLRDVPF
210 220 230 240 250
SIVYFPLFAN LNELGRPASG EKSPFYVSFL AGCVAGSAAA VAVNPCDVVK
260 270 280 290 300
TRLQSLQRGI NEDTYSGFLD CARKILQNEG PSAFLKGAYC RALVIAPLFG
310 320
IAQVVYFLGI AETLLGLPRV QP
Length:322
Mass (Da):34,531
Last modified:October 31, 2006 - v1
Checksum:iF322A3618958C337
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123701 mRNA. Translation: AAI23702.1.
RefSeqiNP_001068627.1. NM_001075159.1.
XP_005227358.1. XM_005227301.3.
XP_005227359.1. XM_005227302.3.
XP_005227360.1. XM_005227303.3.
XP_015316820.1. XM_015461334.1.
UniGeneiBt.16050.

Genome annotation databases

EnsembliENSBTAT00000001624; ENSBTAP00000001624; ENSBTAG00000001229.
GeneIDi504371.
KEGGibta:504371.

Similar proteinsi

Entry informationi

Entry nameiGHC1_BOVIN
AccessioniPrimary (citable) accession number: Q08DK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 31, 2006
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families