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Q08DG7 (HXA3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A3
Gene names
Name:HOXA3
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtranscription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Homeobox protein Hox-A3
PRO_0000274485

Regions

DNA binding191 – 25060Homeobox
Motif155 – 1606Antp-type hexapeptide
Compositional bias78 – 13760Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q08DG7 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 1CC8674ED40626EC

FASTA44246,280
        10         20         30         40         50         60 
MQKATYYDSS AIYGGYPYQA ANGFGYNANQ QPYPASTALG ADGEYHRPAC SLQSPANAGS 

        70         80         90        100        110        120 
HPKAHELSEA CLRTLSGPPS QPPVLGEPPL APPPPQAAPP APPQPPAPPQ PPAPTPAAPP 

       130        140        150        160        170        180 
PPSSVSPPQN GSSNPTPASA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SGSSSGESCA 

       190        200        210        220        230        240 
GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ 

       250        260        270        280        290        300 
NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGPGSYLNSM HSLVNSVPYE PQSPPPFSKP 

       310        320        330        340        350        360 
PQGAYGLPPA SYPAPLPSCA PPPPQKRYTA AGAGAGGTPD YDPHAHGLQG NGSYGTPHLQ 

       370        380        390        400        410        420 
GSPVFVGGSY VEPMSNSGPP LFGLTHLPHT ASAAMDYGGA GPLGSGHHHG PGPGEPHPTY 

       430        440 
TDLTAHHPSQ GRIQEAPKLT HL

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Ascending colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC123759 mRNA. Translation: AAI23760.1.
IPIIPI00693889.
RefSeqNP_001070293.1. NM_001076825.1.
UniGeneBt.91842.

3D structure databases

ProteinModelPortalQ08DG7.
SMRQ08DG7. Positions 191-250.
ModBaseSearch...

Proteomic databases

PRIDEQ08DG7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000010700; ENSBTAP00000010700; ENSBTAG00000008139.
GeneID509991.
KEGGbta:509991.

Organism-specific databases

CTD3200.

Phylogenomic databases

eggNOGmaNOG08918.
GeneTreeENSGT00600000084019.
HOVERGENHBG107984.
InParanoidQ08DG7.
OMAGHPKAHE.
OrthoDBEOG4K6G4J.

Family and domain databases

InterProIPR001356. Homeobox.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_eu.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KOK09303.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXA3_BOVIN
AccessionPrimary (citable) accession number: Q08DG7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 31, 2006
Last modified: December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

SIMILARITY comments

Index of protein domains and families

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