Reviewed, UniProtKB/Swiss-Prot Q08DG7 (HXA3_BOVIN)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A3

Gene names

Name:

HOXA3

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Homeobox protein Hox-A3		PRO_0000274485
Regions
	DNA binding	191 – 250	60	Homeobox
	Motif	155 – 160	6	Antp-type hexapeptide
	Compositional bias	78 – 137	60	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q08DG7-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 1CC8674ED40626EC	FASTA	442	46,280
	10 20 30 40 50 60 MQKATYYDSS AIYGGYPYQA ANGFGYNANQ QPYPASTALG ADGEYHRPAC SLQSPANAGS 70 80 90 100 110 120 HPKAHELSEA CLRTLSGPPS QPPVLGEPPL APPPPQAAPP APPQPPAPPQ PPAPTPAAPP 130 140 150 160 170 180 PPSSVSPPQN GSSNPTPASA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SGSSSGESCA 190 200 210 220 230 240 GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ 250 260 270 280 290 300 NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGPGSYLNSM HSLVNSVPYE PQSPPPFSKP 310 320 330 340 350 360 PQGAYGLPPA SYPAPLPSCA PPPPQKRYTA AGAGAGGTPD YDPHAHGLQG NGSYGTPHLQ 370 380 390 400 410 420 GSPVFVGGSY VEPMSNSGPP LFGLTHLPHT ASAAMDYGGA GPLGSGHHHG PGPGEPHPTY 430 440 TDLTAHHPSQ GRIQEAPKLT HL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC123759 mRNA. Translation: AAI23760.1.
IPI	IPI00693889.
RefSeq	NP_001070293.1.
UniGene	Bt.91842
3D structure databases
SMR	Q08DG7. Positions 193-250.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000010700; ENSBTAP00000010700; ENSBTAG00000008139; Bos taurus. [Genome view]
GeneID	509991.
KEGG	bta:509991.
Organism-specific databases
CTD	509991.
Phylogenomic databases
HOVERGEN	Q08DG7.
OMA	YDSSAIY
OrthoDB	EOG9HHRMP
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA3_BOVIN

Accession

Primary (citable) accession number: Q08DG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	October 31, 2006
Last modified:	November 24, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)