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Protein

Cytochrome c oxidase assembly protein COX15 homolog

Gene

COX15

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the biosynthesis of heme A.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-189451. Heme biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX15 homolog
Gene namesi
Name:COX15
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Transmembranei157 – 17418HelicalSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Transmembranei360 – 38021HelicalSequence analysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Cytochrome c oxidase assembly protein COX15 homologPRO_0000274486Add
BLAST

Proteomic databases

PaxDbiQ08DG6.
PRIDEiQ08DG6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055003.

Family & Domainsi

Sequence similaritiesi

Belongs to the COX15/CtaA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2725. Eukaryota.
COG1612. LUCA.
GeneTreeiENSGT00390000002223.
HOVERGENiHBG051086.
InParanoidiQ08DG6.
KOiK02259.
OMAiTALIYIV.
OrthoDBiEOG7X9G74.
TreeFamiTF105073.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
IPR009003. Peptidase_S1_PA.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08DG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRLLFTPLT AFLGSPCLRL LVPRVAPRTQ CGCSCGIRRP LRPGQYSTIS
60 70 80 90 100
DVALQPGRST VSLPSKAAER VVGRWLLVCS GTVAGAVILG GVTRLTESGL
110 120 130 140 150
SMVDWHLIKE MKPPTSKEEW EAEFQKYQQF PEFKILNHDM TLAEFKFIWY
160 170 180 190 200
MEYSHRMWGR LVGLAYILPA AYFWKKGWLT RGLKGRVLAL CGLVCFQGLL
210 220 230 240 250
GWYMVKSGLE EKPDSHDIPR VSQYRLAAHL GSALVLYCAS LWTSLSLLLP
260 270 280 290 300
QHKLTETRQL LRLRRFAHGT AGLVFLTALS GAFVAGLDAG LVYNSFPKMG
310 320 330 340 350
ESWIPEDLFT FSPLLRNVFE NPTMVQFDHR VLGIASVTAV TVLYFLSRRI
360 370 380 390 400
PLPRRTKIAA TTLLALAYTQ VGLGISTLLM YVPTPLAATH QSGSLALLSV
410
ALWLMNELRR VPK
Length:413
Mass (Da):46,126
Last modified:October 31, 2006 - v1
Checksum:iA5E1CB2F19BF559B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123760 mRNA. Translation: AAI23761.1.
RefSeqiNP_001070329.1. NM_001076861.1.
UniGeneiBt.26951.

Genome annotation databases

EnsembliENSBTAT00000064176; ENSBTAP00000055003; ENSBTAG00000045703.
GeneIDi517811.
KEGGibta:517811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123760 mRNA. Translation: AAI23761.1.
RefSeqiNP_001070329.1. NM_001076861.1.
UniGeneiBt.26951.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055003.

Proteomic databases

PaxDbiQ08DG6.
PRIDEiQ08DG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000064176; ENSBTAP00000055003; ENSBTAG00000045703.
GeneIDi517811.
KEGGibta:517811.

Organism-specific databases

CTDi1355.

Phylogenomic databases

eggNOGiKOG2725. Eukaryota.
COG1612. LUCA.
GeneTreeiENSGT00390000002223.
HOVERGENiHBG051086.
InParanoidiQ08DG6.
KOiK02259.
OMAiTALIYIV.
OrthoDBiEOG7X9G74.
TreeFamiTF105073.

Enzyme and pathway databases

ReactomeiR-BTA-189451. Heme biosynthesis.

Miscellaneous databases

NextBioi20872513.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
IPR009003. Peptidase_S1_PA.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiCOX15_BOVIN
AccessioniPrimary (citable) accession number: Q08DG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 31, 2006
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.