Reviewed, UniProtKB/Swiss-Prot Q08DF4 (DYN1_BOVIN)

Names and origin

Protein names

Recommended name:
    Dynamin-1
    EC=3.6.5.5

Gene names

Name:

DNM1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	856 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis By similarity.
Catalytic activity	GTP + H2O = GDP + phosphate.
Subunit structure	Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Note: Microtubule-associated By similarity.
Sequence similarities	Belongs to the dynamin family. Contains 1 GED domain. Contains 1 PH domain.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cytoplasm Cytoskeleton Microtubule
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase Motor protein
PTM	Nitration Phosphoprotein
Gene Ontology (GO)
Biological process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro motor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 856	856	Dynamin-1		PRO_0000319949
Regions
	Domain	519 – 625	107	PH
	Domain	659 – 750	92	GED
	Nucleotide binding	38 – 45	8	GTP By similarity
	Nucleotide binding	136 – 140	5	GTP By similarity
	Nucleotide binding	205 – 208	4	GTP By similarity
Amino acid modifications
	Modified residue	80	1	Phosphotyrosine By similarity
	Modified residue	125	1	Nitrated tyrosine By similarity
	Modified residue	125	1	Phosphotyrosine By similarity
	Modified residue	354	1	Phosphotyrosine By similarity
	Modified residue	774	1	Phosphoserine By similarity
	Modified residue	776	1	Phosphothreonine By similarity
	Modified residue	778	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q08DF4-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 6E87EAF8E541DE83	FASTA	856	96,252
	10 20 30 40 50 60 MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVNATTEY AEFLHCKGKK FTDFEEVRLE IEAETDRVTG TNKGISPVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP DIEFQIRDML MQFVTKENCL ILAVSPANSD 190 200 210 220 230 240 LANSDALKVA KEVDPQGQRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 250 260 270 280 290 300 DIDGKKDITA ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 310 320 330 340 350 360 QSQLLSIEKE VEEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ IDTYELSGGA 370 380 390 400 410 420 RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT GLFTPDLAFE ATVKKQVQKL 430 440 450 460 470 480 KEPSIKCVDM VVSELTATIR KCSEKLQQYP RLREEMERIV TTHIREREGR TKEQVMLLID 490 500 510 520 530 540 IELAYMNTNH EDFIGFANAQ QRSNQMNKKK ASGNQDEILV IRKGWLTINN IGIMKGGSKE 550 560 570 580 590 600 YWFVLTAENL SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 610 620 630 640 650 660 RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS MDPQLERQVE 670 680 690 700 710 720 TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE LLANLYSCGD QNTLMEESAE 730 740 750 760 770 780 QAQRRDEMLR MYHALKEALS IIGDINTTTV STPMPPPVDD SWLQVQSVPT GRRSPTSSPT 790 800 810 820 830 840 PQRRAPAVPP ARPGSRGPAP GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP 850 PGVPSQPIGS GKSIPS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hippocampus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC123778 mRNA. Translation: AAI23779.1.
IPI	IPI00714149.
RefSeq	NP_001070288.1.
UniGene	Bt.40512
3D structure databases
SMR	Q08DF4. Positions 6-304, 518-630.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000032743; ENSBTAP00000032672; ENSBTAG00000011307; Bos taurus. [Genome view]
GeneID	508794.
KEGG	bta:508794.
Organism-specific databases
CTD	508794.
Phylogenomic databases
HOVERGEN	Q08DF4.
OMA	KTSGNQD.
Enzyme and pathway databases
BRENDA	3.6.5.5. 251.
Family and domain databases
InterPro	IPR000375. Dynamin_central. IPR001401. Dynamin_GTPase. IPR019762. Dynamin_GTPase_CS. IPR003130. GED. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF01031. Dynamin_M. 1 hit. PF00350. Dynamin_N. 1 hit. PF02212. GED. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00195. DYNAMIN.
SMART	SM00053. DYNc. 1 hit. SM00302. GED. 1 hit. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS00410. DYNAMIN. 1 hit. PS51388. GED. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DYN1_BOVIN

Accession

Primary (citable) accession number: Q08DF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 31, 2006
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)