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Protein

Arylsulfatase A

Gene

ARSA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes cerebroside sulfate.By similarity

Catalytic activityi

A cerebroside 3-sulfate + H2O = a cerebroside + sulfate.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29CalciumBy similarity1
Metal bindingi30CalciumBy similarity1
Active sitei69NucleophileBy similarity1
Metal bindingi69Calcium; via 3-oxoalanineBy similarity1
Binding sitei123SubstrateBy similarity1
Active sitei125By similarity1
Binding sitei150SubstrateBy similarity1
Binding sitei229SubstrateBy similarity1
Metal bindingi281CalciumBy similarity1
Metal bindingi282CalciumBy similarity1
Binding sitei302SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-1660662 Glycosphingolipid metabolism
R-BTA-1663150 The activation of arylsulfatases
R-BTA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase A (EC:3.1.6.8)
Short name:
ASA
Alternative name(s):
Cerebroside-sulfatase
Gene namesi
Name:ARSA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:50217 ARSA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000027363619 – 507Arylsulfatase AAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei693-oxoalanine (Cys)By similarity1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08DD1
PRIDEiQ08DD1

Expressioni

Gene expression databases

BgeeiENSBTAG00000016053

Interactioni

Subunit structurei

Homodimer at neutral pH and homooctamer at acidic pH. Exists both as a single chain of 58 kDa (component A) or as a chain of 50 kDa (component B) linked by disulfide bond(s) to a 7 kDa chain (component C). Interacts with SUMF1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021364

Structurei

3D structure databases

ProteinModelPortaliQ08DD1
SMRiQ08DD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00760000119062
HOGENOMiHOG000135352
HOVERGENiHBG004283
InParanoidiQ08DD1
KOiK01134
OMAiFWPGHIA
OrthoDBiEOG091G07AL
TreeFamiTF314186

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALWTLTLA LAAGLAAASP PNILLIFADD LGYGDLGSYG HPSSTTPNLD
60 70 80 90 100
QLAAGGLRFT DFYVPVSLCT PSRAALLTGR LPVRMGLYPG VLEPSSRGGL
110 120 130 140 150
PLDEVTLAEV LAAQGYLTGI AGKWHLGVGP EGAFLPPHHG FHRFLGIPYS
160 170 180 190 200
HDQGPCQNLT CFPPATPCEG ICDQGLVPIP LLANLSVEAQ PPWLPGLEAR
210 220 230 240 250
YVAFARDLMT DAQHQGRPFF LYYASHHTHY PQFSGQSFPG HSGRGPFGDS
260 270 280 290 300
LMELDAAVGA LMTAVGDLGL LGETLVFFTA DNGPETMRMS HGGCSGLLRC
310 320 330 340 350
GKGTTFEGGV REPALAFWPG HIAPGVTHEL ASSLDLLPTL AALAGAQLPN
360 370 380 390 400
ITLDGVDLSP LLLGTGKSPR HTLFFYSAYP DEVRGVFAVR SGKYKAHFFT
410 420 430 440 450
QGSVHSDTTA DPACHASNPL TAHEPPLLFD LSEDPGENYN LLDSVDEVAP
460 470 480 490 500
EALQAVKQLE LLKAQFDAAM TFGPSQMAQG EDPTLQVCCQ PSCTPRPSCC

HCPEFQP
Length:507
Mass (Da):53,807
Last modified:October 31, 2006 - v1
Checksum:iCFE35552A9A4992A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123816 mRNA Translation: AAI23817.1
RefSeqiNP_001068673.1, NM_001075205.1
XP_005207557.1, XM_005207500.3
UniGeneiBt.1076

Genome annotation databases

EnsembliENSBTAT00000021364; ENSBTAP00000021364; ENSBTAG00000016053
GeneIDi505514
KEGGibta:505514

Similar proteinsi

Entry informationi

Entry nameiARSA_BOVIN
AccessioniPrimary (citable) accession number: Q08DD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health