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Protein

Arylsulfatase A

Gene

ARSA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes cerebroside sulfate.By similarity

Catalytic activityi

A cerebroside 3-sulfate + H2O = a cerebroside + sulfate.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291CalciumBy similarity
Metal bindingi30 – 301CalciumBy similarity
Metal bindingi69 – 691Calcium; via 3-oxoalanineBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Active sitei125 – 1251By similarity
Binding sitei150 – 1501SubstrateBy similarity
Binding sitei229 – 2291SubstrateBy similarity
Metal bindingi281 – 2811CalciumBy similarity
Metal bindingi282 – 2821CalciumBy similarity
Binding sitei302 – 3021SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-1660662. Glycosphingolipid metabolism.
R-BTA-1663150. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase A (EC:3.1.6.8)
Short name:
ASA
Alternative name(s):
Cerebroside-sulfatase
Gene namesi
Name:ARSA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 507489Arylsulfatase APRO_0000273636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 6913-oxoalanine (Cys)By similarity
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08DD1.
PRIDEiQ08DD1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016053.

Interactioni

Subunit structurei

Homodimer at neutral pH and homooctamer at acidic pH. Exists both as a single chain of 58 kDa (component A) or as a chain of 50 kDa (component B) linked by disulfide bond(s) to a 7 kDa chain (component C). Interacts with SUMF1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021364.

Structurei

3D structure databases

ProteinModelPortaliQ08DD1.
SMRiQ08DD1. Positions 20-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135352.
HOVERGENiHBG004283.
InParanoidiQ08DD1.
KOiK01134.
OMAiFFYSAYP.
OrthoDBiEOG091G07AL.
TreeFamiTF314186.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08DD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALWTLTLA LAAGLAAASP PNILLIFADD LGYGDLGSYG HPSSTTPNLD
60 70 80 90 100
QLAAGGLRFT DFYVPVSLCT PSRAALLTGR LPVRMGLYPG VLEPSSRGGL
110 120 130 140 150
PLDEVTLAEV LAAQGYLTGI AGKWHLGVGP EGAFLPPHHG FHRFLGIPYS
160 170 180 190 200
HDQGPCQNLT CFPPATPCEG ICDQGLVPIP LLANLSVEAQ PPWLPGLEAR
210 220 230 240 250
YVAFARDLMT DAQHQGRPFF LYYASHHTHY PQFSGQSFPG HSGRGPFGDS
260 270 280 290 300
LMELDAAVGA LMTAVGDLGL LGETLVFFTA DNGPETMRMS HGGCSGLLRC
310 320 330 340 350
GKGTTFEGGV REPALAFWPG HIAPGVTHEL ASSLDLLPTL AALAGAQLPN
360 370 380 390 400
ITLDGVDLSP LLLGTGKSPR HTLFFYSAYP DEVRGVFAVR SGKYKAHFFT
410 420 430 440 450
QGSVHSDTTA DPACHASNPL TAHEPPLLFD LSEDPGENYN LLDSVDEVAP
460 470 480 490 500
EALQAVKQLE LLKAQFDAAM TFGPSQMAQG EDPTLQVCCQ PSCTPRPSCC

HCPEFQP
Length:507
Mass (Da):53,807
Last modified:October 31, 2006 - v1
Checksum:iCFE35552A9A4992A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123816 mRNA. Translation: AAI23817.1.
RefSeqiNP_001068673.1. NM_001075205.1.
XP_005207557.1. XM_005207500.3.
UniGeneiBt.1076.

Genome annotation databases

EnsembliENSBTAT00000021364; ENSBTAP00000021364; ENSBTAG00000016053.
GeneIDi505514.
KEGGibta:505514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123816 mRNA. Translation: AAI23817.1.
RefSeqiNP_001068673.1. NM_001075205.1.
XP_005207557.1. XM_005207500.3.
UniGeneiBt.1076.

3D structure databases

ProteinModelPortaliQ08DD1.
SMRiQ08DD1. Positions 20-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021364.

Proteomic databases

PaxDbiQ08DD1.
PRIDEiQ08DD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021364; ENSBTAP00000021364; ENSBTAG00000016053.
GeneIDi505514.
KEGGibta:505514.

Organism-specific databases

CTDi410.

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135352.
HOVERGENiHBG004283.
InParanoidiQ08DD1.
KOiK01134.
OMAiFFYSAYP.
OrthoDBiEOG091G07AL.
TreeFamiTF314186.

Enzyme and pathway databases

ReactomeiR-BTA-1660662. Glycosphingolipid metabolism.
R-BTA-1663150. The activation of arylsulfatases.

Gene expression databases

BgeeiENSBTAG00000016053.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARSA_BOVIN
AccessioniPrimary (citable) accession number: Q08DD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.