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Protein

Syntaxin-5

Gene

STX5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-BTA-204005 COPII-mediated vesicle transport
R-BTA-5694530 Cargo concentration in the ER
R-BTA-6807878 COPI-mediated anterograde transport
R-BTA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-5
Gene namesi
Name:STX5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Organism-specific databases

VGNCiVGNC:35441 STX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 333CytoplasmicSequence analysisAdd BLAST333
Transmembranei334 – 354Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini355VesicularSequence analysis1

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002840721 – 355Syntaxin-5Add BLAST355

Proteomic databases

PaxDbiQ08DB5
PRIDEiQ08DB5

Expressioni

Gene expression databases

BgeeiENSBTAG00000009490

Interactioni

Subunit structurei

Part of a ternary complex containing STX5A, NSFL1C and VCP (By similarity). Part of a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2 and YKT6. This complex also includes VTI1A (By similarity). Interacts with COG4 (By similarity). Interacts with GM130/GOLGA2 (By similarity). Interacts (via IxM motif) with SEC24C and SEC24D; mediates STX5 packaging into COPII-coated vesicles (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043848

Structurei

3D structure databases

ProteinModelPortaliQ08DB5
SMRiQ08DB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 325t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili287 – 318Sequence analysisAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi245 – 247IxM motif; signal for cargo packaging into COPII-coated vesiclesBy similarity3

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0812 Eukaryota
ENOG410Y2MB LUCA
GeneTreeiENSGT00390000000652
HOGENOMiHOG000194860
HOVERGENiHBG001973
InParanoidiQ08DB5
KOiK08490
OMAiQDRTNEF
OrthoDBiEOG091G0HR8
TreeFamiTF315068

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR021538 Syntaxin-5_N
IPR006012 Syntaxin/epimorphin_CS
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF11416 Syntaxin-5_N, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q08DB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AGSSSSDIAP LPPPVALVPP
60 70 80 90 100
PPDTMSCRDR TQEFLSACKS LQSRQNGIQA NKPALRAVRQ RSEFTLMAKR
110 120 130 140 150
IGKDLSNTFA KLEKLTILAK RKSLFDDKAV EIEELTYIIK QDINSLNKQI
160 170 180 190 200
AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ SKLASMSNDF KSVLEVRTEN
210 220 230 240 250
LKQQRSRREQ FSRAPVSALP LAPNHLGGGA VVLGAESRAS GDVAIDMMDS
260 270 280 290 300
RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET
310 320 330 340 350
IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF

VVFLA
Length:355
Mass (Da):39,546
Last modified:October 31, 2006 - v1
Checksum:i1E6E1A2CAF912B89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123843 mRNA Translation: AAI23844.1
RefSeqiNP_001068912.1, NM_001075444.1
XP_005226961.1, XM_005226904.3
XP_005226962.1, XM_005226905.3
UniGeneiBt.12416

Genome annotation databases

EnsembliENSBTAT00000046561; ENSBTAP00000043848; ENSBTAG00000009490
GeneIDi510312
KEGGibta:510312

Similar proteinsi

Entry informationi

Entry nameiSTX5_BOVIN
AccessioniPrimary (citable) accession number: Q08DB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 31, 2006
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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