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Protein

Syntaxin-5

Gene

STX5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-BTA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-BTA-5694530. Cargo concentration in the ER.
R-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-5
Gene namesi
Name:STX5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

  • Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Single-pass type IV membrane protein Sequence analysis
  • Golgi apparatus membrane By similarity

  • Note: Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 333CytoplasmicSequence analysisAdd BLAST333
Transmembranei334 – 354Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini355VesicularSequence analysis1

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002840721 – 355Syntaxin-5Add BLAST355

Proteomic databases

PaxDbiQ08DB5.
PRIDEiQ08DB5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009490.

Interactioni

Subunit structurei

Part of a ternary complex containing STX5A, NSFL1C and VCP (By similarity). Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2 and YKT6. This complex also includes VTI1A (By similarity). Interacts with COG4 (By similarity). Interacts with GM130/GOLGA2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043848.

Structurei

3D structure databases

ProteinModelPortaliQ08DB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 325t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili287 – 318Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0812. Eukaryota.
ENOG410Y2MB. LUCA.
GeneTreeiENSGT00390000000652.
HOGENOMiHOG000194860.
HOVERGENiHBG001973.
InParanoidiQ08DB5.
KOiK08490.
OMAiNQPGINN.
OrthoDBiEOG091G0HR8.
TreeFamiTF315068.

Family and domain databases

InterProiIPR021538. Syntaxin-5_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF11416. Syntaxin-5_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08DB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AGSSSSDIAP LPPPVALVPP
60 70 80 90 100
PPDTMSCRDR TQEFLSACKS LQSRQNGIQA NKPALRAVRQ RSEFTLMAKR
110 120 130 140 150
IGKDLSNTFA KLEKLTILAK RKSLFDDKAV EIEELTYIIK QDINSLNKQI
160 170 180 190 200
AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ SKLASMSNDF KSVLEVRTEN
210 220 230 240 250
LKQQRSRREQ FSRAPVSALP LAPNHLGGGA VVLGAESRAS GDVAIDMMDS
260 270 280 290 300
RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET
310 320 330 340 350
IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF

VVFLA
Length:355
Mass (Da):39,546
Last modified:October 31, 2006 - v1
Checksum:i1E6E1A2CAF912B89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123843 mRNA. Translation: AAI23844.1.
RefSeqiNP_001068912.1. NM_001075444.1.
XP_005226961.1. XM_005226904.3.
XP_005226962.1. XM_005226905.3.
UniGeneiBt.12416.

Genome annotation databases

EnsembliENSBTAT00000046561; ENSBTAP00000043848; ENSBTAG00000009490.
GeneIDi510312.
KEGGibta:510312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123843 mRNA. Translation: AAI23844.1.
RefSeqiNP_001068912.1. NM_001075444.1.
XP_005226961.1. XM_005226904.3.
XP_005226962.1. XM_005226905.3.
UniGeneiBt.12416.

3D structure databases

ProteinModelPortaliQ08DB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043848.

Proteomic databases

PaxDbiQ08DB5.
PRIDEiQ08DB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000046561; ENSBTAP00000043848; ENSBTAG00000009490.
GeneIDi510312.
KEGGibta:510312.

Organism-specific databases

CTDi6811.

Phylogenomic databases

eggNOGiKOG0812. Eukaryota.
ENOG410Y2MB. LUCA.
GeneTreeiENSGT00390000000652.
HOGENOMiHOG000194860.
HOVERGENiHBG001973.
InParanoidiQ08DB5.
KOiK08490.
OMAiNQPGINN.
OrthoDBiEOG091G0HR8.
TreeFamiTF315068.

Enzyme and pathway databases

ReactomeiR-BTA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-BTA-5694530. Cargo concentration in the ER.
R-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811438. Intra-Golgi traffic.

Gene expression databases

BgeeiENSBTAG00000009490.

Family and domain databases

InterProiIPR021538. Syntaxin-5_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF11416. Syntaxin-5_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX5_BOVIN
AccessioniPrimary (citable) accession number: Q08DB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.