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Protein

Cyclic AMP-dependent transcription factor ATF-1

Gene

ATF1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-199920. CREB phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-1
Short name:
cAMP-dependent transcription factor ATF-1
Alternative name(s):
Activating transcription factor 1
Gene namesi
Name:ATF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Cyclic AMP-dependent transcription factor ATF-1PRO_0000285214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA5PROSITE-ProRule annotation
Modified residuei197 – 1971Phosphoserine; by HIPK2PROSITE-ProRule annotationBy similarity

Post-translational modificationi

Phosphorylated at Ser-197 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ08DA8.
PRIDEiQ08DA8.

PTM databases

iPTMnetiQ08DA8.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with HIPK2 and CDK3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024135.

Structurei

3D structure databases

ProteinModelPortaliQ08DA8.
SMRiQ08DA8. Positions 50-75, 214-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9060KIDPROSITE-ProRule annotationAdd
BLAST
Domaini212 – 27059bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni214 – 23825Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni240 – 26122Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
Contains 1 KID (kinase-inducible) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3584. Eukaryota.
ENOG410ZZJZ. LUCA.
GeneTreeiENSGT00390000008655.
HOGENOMiHOG000007365.
HOVERGENiHBG011077.
InParanoidiQ08DA8.
KOiK09053.
OMAiHIAQQMS.
OrthoDBiEOG72G18D.
TreeFamiTF106464.

Family and domain databases

InterProiIPR029825. ATF1.
IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PANTHERiPTHR22952:SF148. PTHR22952:SF148. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08DA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSHKSNTS ETAPQSGSTV QAAHISHIAQ QVSSLSESEE SQDSSDSIGS
60 70 80 90 100
SQKTHGILAR RPSYRKILKD LSSEDIRGRK GDGENPGVSA VTSMSVPTPI
110 120 130 140 150
YQTSTGQYIA IAPNGALQLA SPGTDGVQGL QTLTMTNSGS TQQGTTILQY
160 170 180 190 200
AQTSDGQQIL VPSNQVVVQT ASGDMQTYQI RTTPSATSLP QTVVMTSPVT
210 220 230 240 250
LTSQTSKTDD PQLKREIRLM KNREAARECR RKKKEYVKCL ENRVAVLENQ
260 270
NKTLIEELKT LKDLYSNKSV
Length:270
Mass (Da):29,261
Last modified:October 31, 2006 - v1
Checksum:i4DC5B06A6CBC7103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123855 mRNA. Translation: AAI23856.1.
RefSeqiNP_001068757.1. NM_001075289.1.
XP_005206335.1. XM_005206278.3.
UniGeneiBt.6860.

Genome annotation databases

EnsembliENSBTAT00000024135; ENSBTAP00000024135; ENSBTAG00000018131.
GeneIDi506967.
KEGGibta:506967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123855 mRNA. Translation: AAI23856.1.
RefSeqiNP_001068757.1. NM_001075289.1.
XP_005206335.1. XM_005206278.3.
UniGeneiBt.6860.

3D structure databases

ProteinModelPortaliQ08DA8.
SMRiQ08DA8. Positions 50-75, 214-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024135.

PTM databases

iPTMnetiQ08DA8.

Proteomic databases

PaxDbiQ08DA8.
PRIDEiQ08DA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024135; ENSBTAP00000024135; ENSBTAG00000018131.
GeneIDi506967.
KEGGibta:506967.

Organism-specific databases

CTDi466.

Phylogenomic databases

eggNOGiKOG3584. Eukaryota.
ENOG410ZZJZ. LUCA.
GeneTreeiENSGT00390000008655.
HOGENOMiHOG000007365.
HOVERGENiHBG011077.
InParanoidiQ08DA8.
KOiK09053.
OMAiHIAQQMS.
OrthoDBiEOG72G18D.
TreeFamiTF106464.

Enzyme and pathway databases

ReactomeiR-BTA-199920. CREB phosphorylation.

Family and domain databases

InterProiIPR029825. ATF1.
IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PANTHERiPTHR22952:SF148. PTHR22952:SF148. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiATF1_BOVIN
AccessioniPrimary (citable) accession number: Q08DA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 31, 2006
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.