Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclic AMP-dependent transcription factor ATF-1

Gene

ATF1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-199920 CREB phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-1
Short name:
cAMP-dependent transcription factor ATF-1
Alternative name(s):
Activating transcription factor 1
Gene namesi
Name:ATF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:26239 ATF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002852141 – 270Cyclic AMP-dependent transcription factor ATF-1Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA5PROSITE-ProRule annotationBy similarity1
Modified residuei197Phosphoserine; by HIPK2PROSITE-ProRule annotationBy similarity1
Cross-linki207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated at Ser-197 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ08DA8
PRIDEiQ08DA8

PTM databases

iPTMnetiQ08DA8

Expressioni

Gene expression databases

BgeeiENSBTAG00000018131

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with HIPK2 and CDK3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024135

Structurei

3D structure databases

ProteinModelPortaliQ08DA8
SMRiQ08DA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 90KIDPROSITE-ProRule annotationAdd BLAST60
Domaini212 – 270bZIPPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 238Basic motifPROSITE-ProRule annotationAdd BLAST25
Regioni240 – 261Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiKOG3584 Eukaryota
ENOG410ZZJZ LUCA
GeneTreeiENSGT00390000008655
HOGENOMiHOG000007365
HOVERGENiHBG011077
InParanoidiQ08DA8
KOiK09053
OMAiHIAQQMS
OrthoDBiEOG091G0FTJ
TreeFamiTF106464

Family and domain databases

InterProiView protein in InterPro
IPR029825 ATF1
IPR004827 bZIP
IPR003102 Coactivator_CBP_pKID
IPR001630 Leuzip_CREB
PANTHERiPTHR22952:SF258 PTHR22952:SF258, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF02173 pKID, 1 hit
PRINTSiPR00041 LEUZIPPRCREB
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
PS50953 KID, 1 hit

Sequencei

Sequence statusi: Complete.

Q08DA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSHKSNTS ETAPQSGSTV QAAHISHIAQ QVSSLSESEE SQDSSDSIGS
60 70 80 90 100
SQKTHGILAR RPSYRKILKD LSSEDIRGRK GDGENPGVSA VTSMSVPTPI
110 120 130 140 150
YQTSTGQYIA IAPNGALQLA SPGTDGVQGL QTLTMTNSGS TQQGTTILQY
160 170 180 190 200
AQTSDGQQIL VPSNQVVVQT ASGDMQTYQI RTTPSATSLP QTVVMTSPVT
210 220 230 240 250
LTSQTSKTDD PQLKREIRLM KNREAARECR RKKKEYVKCL ENRVAVLENQ
260 270
NKTLIEELKT LKDLYSNKSV
Length:270
Mass (Da):29,261
Last modified:October 31, 2006 - v1
Checksum:i4DC5B06A6CBC7103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123855 mRNA Translation: AAI23856.1
RefSeqiNP_001068757.1, NM_001075289.1
XP_005206335.1, XM_005206278.3
UniGeneiBt.6860

Genome annotation databases

EnsembliENSBTAT00000024135; ENSBTAP00000024135; ENSBTAG00000018131
GeneIDi506967
KEGGibta:506967

Entry informationi

Entry nameiATF1_BOVIN
AccessioniPrimary (citable) accession number: Q08DA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health